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Cited by 273

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Sphingosine‐1‐phosphate: signaling inside and out

Open access
Spiegel, Sarah, Milstien, Sheldon·2000·FEBS Letters

Abstract

Ample evidence indicates that sphingosine‐1‐phosphate (SPP) can serve as an intracellular second messenger regulating calcium mobilization, and cell growth and survival. Moreover, the dynamic balance between levels of the sphingolipid metabolites, ceramide and SPP, and consequent regulation of opposing signaling pathways, is an important factor that determines whether a cell survives or dies. SPP has recently also been shown to be the ligand for the EDG‐1 family of G‐protein‐coupled receptors, which now includes EDG‐1, ‐3, ‐5, ‐6 and ‐8. SPP is thus a lipid mediator that has novel dual actions signaling inside and outside of the cell.

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Crossref · 10.1016/s0014-5793(00)01670-7

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Metadata

Authors
Spiegel, S., & Milstien, S.
Venue
FEBS Letters
Publisher
Wiley
Published
2000-06-26
Volume
476
Issue
1-2
Pages
55-57
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
OpenAlex
W2079930884
Cited by
273
References
25
FWCI
11.15
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Sphingosine‐1‐phosphate: signaling inside and out. https://app.cochat.ai/papers/10.1016/s0014-5793(00)01670-7
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Spiegel, S., & Milstien, S. (2000). Sphingosine‐1‐phosphate: signaling inside and out. FEBS Letters. https://doi.org/10.1016/s0014-5793(00)01670-7

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.