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Role of reactive oxygen species and phosphatidylinositol 3‐kinase in cardiomyocyte differentiation of embryonic stem cells
Open accessAbstract
Cardiotypic development in embryonic stem cell‐derived embryoid bodies may be regulated by reactive oxygen species (ROS). ROS were generated by a NADPH oxidase‐like enzyme which was transiently expressed during the time course of embryoid body development. Incubation with either H 2 O 2 or menadione enhanced cardiomyogenesis, whereas the radical scavengers trolox, pyrrolidinedithiocarbamate and N‐acetylcysteine exerted inhibitory effects. The phosphatidylinositol 3‐kinase (PI‐3‐kinase) inhibitors LY294002 and wortmannin abolished cardiac commitment and downregulated ROS in embryoid bodies. Coadministration of LY294002 with prooxidants resumed cardiomyocyte differentiation, indicating a role for PI‐3‐kinase in the regulation of the intracellular redox state.
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Cited by
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989
Hydrogen peroxide sensing and signaling
Veal, E. A., Day, A. M., & Morgan, B. A. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.03.016 · Cited by 1,604
HANLEY, P., & DAUT, J. (2005) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2005.04.002 · Cited by 218
Piccoli, C., Ria, R., Scrima, R., Cela, O., D'Aprile, A., Boffoli, D., Falzetti, F., Tabilio, A., & Capitanio, N. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500047200 · Cited by 209
McDevitt, T. C., Laflamme, M. A., & Murry, C. E. (2005) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2005.09.007 · Cited by 183
Metadata
- Authors
- Sauer, H., Rahimi, G., Hescheler, J., & Wartenberg, M.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2000-07-03
- Volume
- 476
- Issue
- 3
- Pages
- 218-223
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2027936803
- Cited by
- 243
- References
- 0
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sauer, H., Rahimi, G., Hescheler, J., & Wartenberg, M. (2000). Role of reactive oxygen species and phosphatidylinositol 3‐kinase in cardiomyocyte differentiation of embryonic stem cells. FEBS Letters. https://doi.org/10.1016/s0014-5793(00)01747-6
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