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Transcriptome meets metabolome: hierarchical and metabolic regulation of the glycolytic pathway
Open accessAbstract
The fact that information flows from DNA to RNA to protein to function suggests that regulation is ‘hierarchical’, i.e. dominated by regulation of gene expression. In the case of dominant regulation at the metabolic level, however, there is no quantitative relationship between mRNA levels and function. We here develop a method to quantitate the relative contributions of metabolic and hierarchical regulation. Applying this method to the glycolytic flux in three species of parasitic protists, we conclude that it is rarely regulated by gene expression alone. This casts strong doubts on whether transcriptome and proteome analysis suffices to assess biological function.
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Cited by
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Growth control of the eukaryote cell: a systems biology study in yeast
Castrillo, J. I., Zeef, L. A., Hoyle, D. C., Zhang, N., Hayes, A., Gardner, D. C., Cornell, M. J., Petty, J., Hakes, L., Wardleworth, L., et al. (2007) · Journal of Biology · doi:10.1186/jbiol54 · Cited by 263
Chubukov, V., Uhr, M., Le Chat, L., Kleijn, R. J., Jules, M., Link, H., Aymerich, S., Stelling, J., & Sauer, U. (2013) · Molecular Systems Biology · doi:10.1038/msb.2013.66 · Cited by 191
Escherichia coli achieves faster growth by increasing catalytic and translation rates of proteins
Valgepea, K., Adamberg, K., Seiman, A., & Vilu, R. (2013) · Molecular BioSystems · doi:10.1039/c3mb70119k · Cited by 145
Rodríguez-Enríquez, S., Carreño-Fuentes, L., Gallardo-Pérez, J. C., Saavedra, E., Quezada, H., Vega, A., Marín-Hernández, A., Olín-Sandoval, V., Torres-Márquez, M. E., & Moreno-Sánchez, R. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.07.010 · Cited by 142
Metadata
- Authors
- ter Kuile, B. H., & Westerhoff, H. V.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2001-07-02
- Volume
- 500
- Issue
- 3
- Pages
- 169-171
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2034354682
- Cited by
- 339
- References
- 0
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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- ter Kuile, B. H., & Westerhoff, H. V. (2001). Transcriptome meets metabolome: hierarchical and metabolic regulation of the glycolytic pathway. FEBS Letters. https://doi.org/10.1016/s0014-5793(01)02613-8
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