The phosphatidylinositol 3‐phosphate‐binding FYVE finger
Abstract
The FYVE zinc finger domain is conserved from yeast (five proteins) to man (27 proteins). It functions in the membrane recruitment of cytosolic proteins by binding to phosphatidylinositol 3-phosphate (PI3P), which is found mainly on endosomes. Here we review recent work that sheds light on the targeting of FYVE finger proteins to PI3P-containing membranes, and how these proteins serve to regulate multiple cellular functions.
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INPP5D encodes a dual-specificity phosphatase that can dephosphorylate both phospholipids and phosphoproteins.
“The inositol polyphosphate-5-phosphatase D (INPP5D) gene encodes a dual-specificity phosphatase that can dephosphorylate both phospholipids and phosphoproteins.”
From Microglial <i>INPP5D</i> limits plaque formation and glial reactivity in the PSAPP mouse model of Alzheimer's disease (2023) · cites this paper as [9]
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References 56 · Cited by 224
- Authors
- Stenmark, H., Aasland, R., & Driscoll, P. C.
- Affiliations
- University of Bergen (NO)
- University College London (GB)
- Corresponding author
- Stenmark, Harald
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2002-01-04
- Volume
- 513
- Issue
- 1
- Pages
- 77-84
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2076261565
- Cited by
- 224
- References
- 56
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 4 · 2023: 9 · 2022: 10 · 2021: 17 · 2020: 5 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 11 · 2015: 4 · 2014: 3 · 2013: 10 · 2012: 7
- FWCI
- 7.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- phosphatidylinositol 3-phosphate, membrane recruitment, endosomes, protein targeting, lipid binding, cytosolic proteins, cell regulation
- MeSH terms
- Amino Acid Sequence, Animals, Binding Sites, Humans, Models, Molecular, Molecular Sequence Data, Nematoda, Protein Conformation, Protein Kinases, Saccharomyces cerevisiae, Sequence Alignment, Sequence Homology, Amino Acid, Protein Structure, Secondary, Phosphatidylinositol Phosphates, Phosphatidylinositol 3-Kinases
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