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Biochemistry of arsenic detoxification
Abstract
All living organisms have systems for arsenic detoxification. The common themes are (a) uptake of As(V) in the form of arsenate by phosphate transporters, (b) uptake of As(III) in the form of arsenite by aquaglyceroporins, (c) reduction of As(V) to As(III) by arsenate reductases, and (d) extrusion or sequestration of As(III). While the overall schemes for arsenic resistance are similar in prokaryotes and eukaryotes, some of the specific proteins are the products of separate evolutionary pathways.
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Cited by
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Gonzalez, A. C. D. O., Costa, T. F., Andrade, Z. D. A., & Medrado, A. R. A. P. (2016) · Anais Brasileiros de Dermatologia · doi:10.1590/abd1806-4841.20164741 · Cited by 1,605
Oremland, R. S., & Stolz, J. F. (2003) · Science · doi:10.1126/science.1081903 · Cited by 1,535
RETRACTED: A Bacterium That Can Grow by Using Arsenic Instead of Phosphorus
Wolfe-Simon, F., Blum, J. S., Kulp, T. R., Gordon, G. W., Hoeft, S. E., Pett-Ridge, J., Stolz, J. F., Webb, S. M., Weber, P. K., Davies, P. C. W., et al. (2011) · Science · doi:10.1126/science.1197258 · Cited by 503
RetractedProtein Design: Toward Functional Metalloenzymes
Yu, F., Cangelosi, V. M., Zastrow, M. L., Tegoni, M., Plegaria, J. S., Tebo, A. G., Mocny, C. S., Ruckthong, L., Qayyum, H., & Pecoraro, V. L. (2014) · Chemical Reviews · doi:10.1021/cr400458x · Cited by 441
vanden Hoven, R. N., & Santini, J. M. (2004) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2004.03.001 · Cited by 160
Metadata
- Authors
- Rosen, B. P.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2002-08-15
- Volume
- 529
- Issue
- 1
- Pages
- 86-92
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2160008637
- Cited by
- 783
- References
- 0
- FWCI
- 19.76
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rosen, B. P. (2002). Biochemistry of arsenic detoxification. FEBS Letters. https://doi.org/10.1016/s0014-5793(02)03186-1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
