The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Phospholipase A2 regulation of arachidonic acid mobilization
Abstract
Phospholipase A 2 (PLA 2) constitutes a growing superfamily of lipolytic enzymes, and to date, at least 19 distinct enzymes have been found in mammals. This class of enzymes has attracted considerable interest as a pharmacological target in view of its role in lipid signaling and its involvement in a variety of inflammatory conditions. PLA 2 s hydrolyze the sn‐2 ester bond of cellular phospholipids, producing a free fatty acid and a lysophospholipid, both of which are lipid signaling molecules. The free fatty acid produced is frequently arachidonic acid (AA, 5,8,11,14‐eicosatetraenoic acid), the precursor of the eicosanoid family of potent inflammatory mediators that includes prostaglandins, thromboxanes, leukotrienes and lipoxins. Multiple PLA 2 enzymes are active within and surrounding the cell and these enzymes have distinct, but interconnected roles in AA release.
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Cites
Cyclooxygenases: Structural, cellular, and molecular biology
Smith, W. L., DeWitt, D. L., & Garavito, R. M. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.145 · Cited by 2,925
Cited by
Raman spectroscopy of lipids: A review
Czamara, K., Majzner, K., Pacia, M. Z., Kochan, K., Kaczor, A., & Baranska, M. (2015) · Journal of Raman Spectroscopy · doi:10.1002/jrs.4607 · Cited by 1,089
Lengqvist, J., Mata de Urquiza, A., Bergman, A.-C., Willson, T. M., Sjövall, J., Perlmann, T., & Griffiths, W. J. (2004) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m400003-mcp200 · Cited by 323
Tracking neuroinflammation in Alzheimer’s disease: the role of positron emission tomography imaging
Zimmer, E. R., Leuzy, A., Benedet, A. L., Breitner, J., Gauthier, S., & Rosa-Neto, P. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-120 · Cited by 121
ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism
Sun, L., Suo, C., Zhang, T., Shen, S., Gu, X., Qiu, S., Zhang, P., Wei, H., Ma, W., Yan, R., et al. (2023) · Nature Chemical Biology · doi:10.1038/s41589-023-01391-6 · Cited by 94
Yano, T., Fujioka, D., Saito, Y., Kobayashi, T., Nakamura, T., Obata, J.-E., Kawabata, K., Watanabe, K., Watanabe, Y., Mishina, H., et al. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvq399 · Cited by 44
Metadata
- Authors
- Balsinde, J., Winstead, M. V., & Dennis, E. A.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2002-09-27
- Volume
- 531
- Issue
- 1
- Pages
- 2-6
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1976282831
- Cited by
- 477
- References
- 1
- FWCI
- 12.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- Balsinde, J., Winstead, M. V., & Dennis, E. A. (2002). Phospholipase A2 regulation of arachidonic acid mobilization. FEBS Letters. https://doi.org/10.1016/s0014-5793(02)03413-0
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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