The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Small interfering RNA and gene silencing in transgenic mice and rats
Open accessAbstract
After short duplexes of synthetic 21–23 nt RNAs (siRNA) were reported to be effective in silencing specific genes, a vector‐based approach for siRNAs was demonstrated in mammalian cultured cell lines. However, the effect of RNA interference (RNAi) on various differentiated cells in live animals remains unknown. In this report, we demonstrate that transgenically supplied siRNA can silence ubiquitously expressed enhanced green fluorescent protein in every part of the mouse and rat body. These results suggest that transgenic RNAi could function as an alternative method of gene silencing by applying homologous recombination to embryonic stem (ES) cells, and should be successful even in species where ES cell lines remain unestablished.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
‘Green mice’ as a source of ubiquitous green cells
Okabe, M., Ikawa, M., Kominami, K., Nakanishi, T., & Nishimune, Y. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00313-x · Cited by 2,581
Self-citation
Cited by
In vivo Switching of Human Melanoma Cells between Proliferative and Invasive States
Hoek, K. S., Eichhoff, O. M., Schlegel, N. C., Döbbeling, U., Kobert, N., Schaerer, L., Hemmi, S., & Dummer, R. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-2491 · Cited by 743
Hu-Lieskovan, S., Heidel, J. D., Bartlett, D. W., Davis, M. E., & Triche, T. J. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0565 · Cited by 567
Spagnou, S., Miller, A. D., & Keller, M. (2004) · Biochemistry · doi:10.1021/bi048950a · Cited by 342
Transgenic RNA interference in ES cell–derived embryos recapitulates a genetic null phenotype
Kunath, T., Gish, G., Lickert, H., Jones, N., Pawson, T., & Rossant, J. (2003) · Nature Biotechnology · doi:10.1038/nbt813 · Cited by 278
Metadata
- Authors
- Hasuwa, H., Kaseda, K., Einarsdottir, T., & Okabe, M.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2002-11-14
- Volume
- 532
- Issue
- 1-2
- Pages
- 227-230
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2128217005
- Cited by
- 266
- References
- 1
- FWCI
- 13.07
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Small interfering RNA and gene silencing in transgenic mice and rats. https://app.cochat.ai/papers/10.1016/s0014-5793(02)03680-3
- The paper
- Hasuwa, H., Kaseda, K., Einarsdottir, T., & Okabe, M. (2002). Small interfering RNA and gene silencing in transgenic mice and rats. FEBS Letters. https://doi.org/10.1016/s0014-5793(02)03680-3
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
