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Cited by 125Protein Kinase Regulation and GTPase SignalingCellular Mechanics and InteractionsCell Adhesion Molecules Research

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

IQGAP1 as signal integrator: Ca 2+ , calmodulin, Cdc42 and the cytoskeleton

Briggs, Michael W, Sacks, David B·2003·FEBS Letters
DOI 10.1016/s0014-5793(03)00333-8
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Abstract

A family of proteins known as IQGAPs have been identified in yeast, amebas and mammals. IQGAPs are multidomain molecules that contain several protein-interacting motifs which mediate binding to target proteins. Mammalian IQGAP1 is a component of signaling networks that are integral to maintaining cytoskeletal architecture and cell-cell adhesion. Published data suggest that IQGAP1 is a scaffolding protein that modulates cross-talk among diverse pathways in complex regulatory circuits. These pathways include modulating the actin cytoskeleton, mediating signaling by Rho family GTPases and calmodulin, regulating E-cadherin and beta-catenin function and organizing microtubules.

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Metadata

Authors
Briggs, M. W., & Sacks, D. B.
Affiliations
Brigham and Women's Hospital (US)
Corresponding author
Sacks, David B
ORCID
Sacks, David B
Venue
FEBS Letters
Publisher
Wiley
Published
2003-04-08
Volume
542
Issue
1-3
Pages
7-11
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
DOI
10.1016/s0014-5793(03)00333-8
OpenAlex
W1986942381
Cited by
125
References
1
Citations by year
2026: 1 · 2025: 2 · 2022: 3 · 2021: 4 · 2020: 7 · 2019: 4 · 2018: 4 · 2017: 7 · 2016: 3 · 2015: 8 · 2014: 4 · 2013: 2 · 2012: 9
FWCI
0.70
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • FEBS Letters (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords
IQGAP1, scaffold proteins, signal integration, calcium signaling, calmodulin, Cdc42, Rho GTPases, actin cytoskeleton, microtubules, cell-cell adhesion, E-cadherin, β-catenin, signaling crosstalk
MeSH terms
Animals, Calmodulin, Carrier Proteins, Cytoskeleton, Models, Biological, Protein Structure, Tertiary, Calcium Signaling, ras GTPase-Activating Proteins, cdc42 GTP-Binding Protein

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