Enhanced permeability transition explains the reduced calcium uptake in cardiac mitochondria from streptozotocin‐induced diabetic rats
Open accessAbstract
Cardiac dysfunction is associated with diabetes. It was previously shown that heart mitochondria from diabetic rats have a reduced calcium accumulation capacity. The objective of this work was to determine whether the reduction in calcium accumulation by cardiac mitochondria from diabetic rats is related to an enhanced susceptibility to induction of the mitochondrial permeability transition. Streptozotocin‐induced diabetic rats were used as a model to study the alterations caused by diabetes in the permeability transition, 21 days after streptozotocin administration. Heart mitochondria were isolated to evaluate respiratory parameters and susceptibility to the calcium‐dependent permeability transition. Our results show that streptozotocin diabetes facilitates the mitochondrial permeability transition in cardiac mitochondria, resulting in decreased mitochondrial calcium accumulation. We also observed that heart mitochondria from diabetic rats had depressed oxygen consumption during the phosphorylative state. The reduced mitochondrial calcium uptake observed in heart mitochondria from diabetic rats is related to an enhanced susceptibility to the permeability transition rather than to damage to the calcium uptake machinery.
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Heart mitochondria from 21-day STZ-diabetic rats with severe hyperglycemia have increased sensitivity to calcium-triggered reduction in membrane potential.
“Oliveria et al. (244) reported that heart mitochondria isolated from 21-day STZ-diabetic rats with severe hyperglycemia demonstrated increased sensitivity to calcium-triggered reduction in membrane potential.”
From Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities (2010) · cites this paper as [244]
The increased sensitivity to calcium-triggered reduction in membrane potential in heart mitochondria from 21-day STZ-diabetic rats is due to greater susceptibility to MPTP opening, as suggested by prevention with cyclosporin.
“Prevention of this with cyclosporin suggested that this was due to greater susceptibility of these mitochondria to opening of the MPTP (244).”
From Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities (2010) · cites this paper as [244]
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References 18 · Cited by 96
Research works printed but not linked: 1
- Rodrigues, B., Poucheret, P., Battell, M.L. and McNeill, J.H. (1999) in: Experimental Models of Diabetes (McNeill, J.H., Ed.), pp. 3^18, CRC Press, Boca Raton, FL.
- Authors
- Oliveira, P. J., Seiça, R., Coxito, P. M., Rolo, A. P., Palmeira, C. M., Santos, M. S., & Moreno, A. J. M.
- Affiliations
- Centro de Neurociências e Biologia Celular (PT)
- ORCID
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2003-10-30
- Volume
- 554
- Issue
- 3
- Pages
- 511-514
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2095063209
- Cited by
- 96
- References
- 18
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 3 · 2019: 4 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 5 · 2014: 6 · 2013: 6 · 2012: 8
- FWCI
- 0.46
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Pathology and Forensic Medicine › Cardiac Ischemia and Reperfusion
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- mitochondrial permeability transition, heart mitochondria, mitochondrial calcium uptake, diabetes mellitus, streptozotocin-induced diabetes, oxygen consumption, mitochondrial respiration, diabetic cardiomyopathy, calcium accumulation
- MeSH terms
- Animals, Calcium, Cell Membrane Permeability, Diabetes Mellitus, Experimental, Intracellular Membranes, Male, Membrane Potentials, Mitochondria, Heart, Oxygen Consumption, Spectrometry, Fluorescence, Rats, Wistar, Rats
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