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Cloning of the human IL‐13Rα1 chain and reconstitution with the IL‐4Rα of a functional IL‐4/IL‐13 receptor complex
Abstract
The human homologue of the recently cloned murine IL‐13 binding protein (IL‐13Rα1) was cloned from a cDNA library derived from the carcinoma cell line CAKI‐1. The cloned cDNA encodes a 427 amino acid protein with two consensus patterns characteristic of the hematopoietic cytokine receptor family and a short cytoplasmic tail. The human protein is 74% identical to the murine IL‐13Rα1, and 27% identical to the human IL‐13Rα2. CHO cells expressing recombinant hIL‐13Rα1 specifically bind IL‐13 (K d≈4 nM) but not IL‐4. Co‐expression of the cloned cDNA with that of IL‐4Rα resulted in a receptor complex that displayed high affinity for IL‐13 (K d≈30 pM), and that allowed cross‐competition of IL‐13 and IL‐4. Electrophoretic mobility shift assay showed that IL‐13 and IL‐4 were able to activate Stat6 in cells expressing both IL‐4Rα and IL‐13Rα1, while no activation was observed in cells expressing either one or the other alone.
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Citations
Cited by
The IL-4 receptor: signaling mechanisms and biologic functions
Nelms, K., Keegan, A. D., Zamorano, J., Ryan, J. J., & Paul, W. E. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.701 · Cited by 1,545
Chiaramonte, M. G., Donaldson, D. D., Cheever, A. W., & Wynn, T. A. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7325 · Cited by 603
Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System
LaPorte, S. L., Juo, Z. S., Vaclavikova, J., Colf, L. A., Qi, X., Heller, N. M., Keegan, A. D., & Garcia, K. C. (2008) · Cell · doi:10.1016/j.cell.2007.12.030 · Cited by 517
The role of IL-13 and its receptor in allergy and inflammatory responses
de Vries, J. E. (1998) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(98)70080-6 · Cited by 403
Impaired Development of Th2 Cells in IL-13-Deficient Mice
McKenzie, G. J., Emson, C. L., Bell, S. E., Anderson, S., Fallon, P., Zurawski, G., Murray, R., Grencis, R., & McKenzie, A. N. J. (1998) · Immunity · doi:10.1016/s1074-7613(00)80625-1 · Cited by 381
Metadata
- Authors
- Miloux, B., Laurent, P., Bonnin, O., Lupker, J., Caput, D., Vita, N., & Ferrara, P.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1997-01-20
- Volume
- 401
- Issue
- 2-3
- Pages
- 163-166
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2052605623
- Cited by
- 214
- References
- 0
- FWCI
- 7.30
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Miloux, B., Laurent, P., Bonnin, O., Lupker, J., Caput, D., Vita, N., & Ferrara, P. (1997). Cloning of the human IL‐13Rα1 chain and reconstitution with the IL‐4Rα of a functional IL‐4/IL‐13 receptor complex. FEBS Letters. https://doi.org/10.1016/s0014-5793(96)01462-7
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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