Cloning of two novel human importin‐α subunits and analysis of the expression pattern of the importin‐α protein family
Open accessAbstract
The import of many proteins into the nucleus is mediated by the importin‐α/β heterodimer. While only one importin‐β gene has been found, several forms of importin‐α have been described. In addition to the three human importin‐αs already identified, we report here the primary structure of two new human importin‐α proteins. The five known human importin‐α subunits can be classified into three subfamilies that appear conserved in higher eukaryotic organisms. We show by immunoblotting that the different importin‐α subfamilies are expressed in a variety of human tissues and mammalian cell lines.
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In humans, six importin-α isoforms are known.
“In humans, six importin-α isoforms are known [41], [42], [43], [44].”
From UV-Induced Nuclear Import of XPA Is Mediated by Importin-α4 in An ATR-Dependent Manner (2013) · cites this paper as [43]
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References 31 · Cited by 228
- Authors
- Köhler, M., Ansieau, S., Prehn, S., Leutz, A., Haller, H., & Hartmann, E.
- Affiliations
- Humboldt-Universität zu Berlin (DE)
- Max Delbrück Center (DE)
- Corresponding author
- Hartmann, Enno
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1997-11-03
- Volume
- 417
- Issue
- 1
- Pages
- 104-108
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2040476467
- Cited by
- 228
- References
- 31
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 5 · 2023: 2 · 2022: 3 · 2021: 7 · 2020: 4 · 2019: 6 · 2018: 5 · 2017: 3 · 2016: 5 · 2015: 6 · 2014: 8 · 2013: 8 · 2012: 4
- FWCI
- 3.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Keywords
- importin alpha, importin beta, nuclear import, protein subfamilies, gene cloning, tissue expression pattern, nuclear localization signal
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, Cloning, Molecular, HeLa Cells, Humans, Molecular Sequence Data, Nuclear Proteins, Rabbits, RNA, Messenger, Tissue Distribution, Tumor Cells, Cultured, Immunoblotting, Gene Expression, Sequence Homology, Amino Acid, DNA, Complementary, Jurkat Cells, Karyopherins
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