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Identification of cDNAs encoding two G protein‐coupled receptors for lysosphingolipids1
Open accessAbstract
The structural similarity of lysosphingolipids to lysophosphatidic acid (LPA) prompted a sequence‐based search for lysosphingolipid receptors using cDNA sequence of the Edg2 human LPA receptor. Two closely related G protein‐coupled receptors, rat H218 and human Edg3, are highly similar to Edg2. When overexpressed in Jurkat cells, H218 and Edg3 activated serum response element‐driven transcriptional reporter gene in response to sphingosine 1‐phosphate (S1P), dihydro‐S1P and sphingosylphosphorylcholine, but not to LPA. H218 and Edg3 expressed in Xenopus oocytes conferred responsiveness to S1P and dihydro‐S1P in agonist‐triggered 45 Ca 2+ efflux. Therefore, H218 and Edg3 are functional receptors for S1P and perhaps other closely related lysosphingolipids.
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Cited by
LPA receptor signaling: pharmacology, physiology, and pathophysiology
Yung, Y. C., Stoddard, N. C., & Chun, J. (2014) · Journal of Lipid Research · doi:10.1194/jlr.r046458 · Cited by 710
Sphingosylphosphorylcholine is a ligand for ovarian cancer G-protein-coupled receptor 1
Xu, Y., Zhu, K., Hong, G., Wu, W., Baudhuin, L. M., Xiao, Y.-J., & Damron, D. S. (2000) · Nature Cell Biology · doi:10.1038/35010529 · Cited by 289
RetractedRegulation of Autophagy and Its Associated Cell Death by “Sphingolipid Rheostat”
Taniguchi, M., Kitatani, K., Kondo, T., Hashimoto-Nishimura, M., Asano, S., Hayashi, A., Mitsutake, S., Igarashi, Y., Umehara, H., Takeya, H., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.416552 · Cited by 140
Chun, J., Kihara, Y., Jonnalagadda, D., & Blaho, V. A. (2019) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010818-021358 · Cited by 131
Metadata
- Authors
- An, S., Bleu, T., Huang, W., Hallmark, O. G., Coughlin, S. R., & Goetzl, E. J.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1997-11-17
- Volume
- 417
- Issue
- 3
- Pages
- 279-282
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1535976290
- Cited by
- 244
- References
- 0
- FWCI
- 11.47
- Type
- journal article
- Language
- en
- Open access
- bronze
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- An, S., Bleu, T., Huang, W., Hallmark, O. G., Coughlin, S. R., & Goetzl, E. J. (1997). Identification of cDNAs encoding two G protein‐coupled receptors for lysosphingolipids1. FEBS Letters. https://doi.org/10.1016/s0014-5793(97)01301-x
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