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Ubch9 conjugates SUMO but not ubiquitin
Open accessAbstract
Ubiquitin conjugating enzymes participate in the thioester cascade that leads to protein ubiquitination. Although Ubc9 is homologous to E2 ubiquitin conjugating enzymes we have shown that it is unable to form a thioester with ubiquitin, but can form a thioester with the small ubiquitin‐like protein SUMO. Thus Ubc9 is a SUMO conjugating enzyme rather than a ubiquitin conjugating enzyme. Transacetylation of Ubc9 by SUMO is not mediated by the E1 ubiquitin activating enzyme, but by a distinct enzymatic activity. SUMO conjugation to target proteins is mediated by a different, but parallel pathway to ubiquitination.
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Citations
Cited by
Alquezar, C., Arya, S., & Kao, A. W. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2020.595532 · Cited by 367
Carbia-Nagashima, A., Gerez, J., Perez-Castro, C., Paez-Pereda, M., Silberstein, S., Stalla, G. K., Holsboer, F., & Arzt, E. (2007) · Cell · doi:10.1016/j.cell.2007.07.044 · Cited by 318
Small Ubiquitin-like Modifier (SUMO) Modification of Natively Unfolded Proteins Tau and α-Synuclein
Dorval, V., & Fraser, P. E. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m510127200 · Cited by 319
Protein SUMOylation modification and its associations with disease
Yang, Y., He, Y., Wang, X., liang, Z., He, G., Zhang, P., Zhu, H., Xu, N., & Liang, S. (2017) · Open Biology · doi:10.1098/rsob.170167 · Cited by 216
Comerford, K. M., Leonard, M. O., Karhausen, J., Carey, R., Colgan, S. P., & Taylor, C. T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337412100 · Cited by 185
Metadata
- Authors
- Desterro, J. M. P., Thomson, J., & Hay, R. T.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1997-11-17
- Volume
- 417
- Issue
- 3
- Pages
- 297-300
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2024935012
- Cited by
- 365
- References
- 0
- FWCI
- 4.28
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Desterro, J. M. P., Thomson, J., & Hay, R. T. (1997). Ubch9 conjugates SUMO but not ubiquitin. FEBS Letters. https://doi.org/10.1016/s0014-5793(97)01305-7
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
