Cleavage and activation of proteinase‐activated receptor‐2 on human neutrophils by gingipain‐R from Porphyromonas gingivalis
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Gingipain‐R, the major arginine‐specific proteinase from Porphyromonas gingivalis, a causative agent of adult periodontal disease, was found to cleave a model peptide representing the cleavage site of proteinase‐activated receptor‐2 (PAR‐2), a G‐protein‐coupled receptor found on the surface of neutrophils. The bacterial proteinase was also shown to induce an increase in the intracellular calcium concentration of enzyme‐treated neutrophils, most probably due to PAR‐2 activation. This response by neutrophils to gingipain‐R may be a mechanism for the development of inflammation associated with periodontal disease.
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Cleavage and activation of PAR-2 on human neutrophils by gingipain-R from Porphyromonas gingivalis induces the release of proinflammatory cytokines such as IL-6, IL-8 and TNF-α.
“For example, cleavage and activation of PAR-2 on human neutrophils by gingipain-R from Porphyromonas gingivalis induces the release of proinflammatory cytokines such as interleukin (IL)-6, IL-8 and tumour necrosis factor (TNF)-α.145”
From The emerging roles of bacterial proteases in intestinal diseases (2023) · cites this paper as [145]
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References 30 · Cited by 171
Research works printed but not linked: 6
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- Authors
- Lourbakos, A., Chinni, C., Thompson, P., Potempa, J., Travis, J., Mackie, E. J., & Pike, R. N.
- Affiliations
- Monash University (AU)
- Jagiellonian University (PL)
- University of Georgia (US)
- The University of Melbourne (AU)
- Corresponding author
- Pike, Robert N
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1998-09-11
- Volume
- 435
- Issue
- 1
- Pages
- 45-48
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1965004400
- Cited by
- 171
- References
- 30
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 7 · 2018: 2 · 2017: 6 · 2016: 7 · 2015: 5 · 2014: 7 · 2013: 6 · 2012: 6
- FWCI
- 9.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health and Medical Research Council
- National Institute of Dental and Craniofacial Research (R01DE009761, DE09761)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Protease and Inhibitor Mechanisms
- Keywords
- protease-activated receptor 2, Porphyromonas gingivalis, neutrophils, bacterial proteases, receptor cleavage, G protein-coupled receptor activation, intracellular calcium, periodontal disease, inflammation
- MeSH terms
- Gingipain Cysteine Endopeptidases, Calcium, Cysteine Endopeptidases, Enzyme Activation, Hemagglutinins, Humans, Hydrolysis, Intracellular Fluid, Neutrophils, Oligopeptides, Peptide Fragments, Porphyromonas gingivalis, Receptors, Thrombin, Adhesins, Bacterial, Receptor, PAR-2
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