The DOI matches its Crossref record.
Trp proteins form store‐operated cation channels in human vascular endothelial cells
Abstract
Members of the Trp protein family have been suggested as the structural basis of store‐operated cation conductances. With this study, we provide evidence for the expression of three isoforms of Trp (hTrp1, 3 and 4) in human umbilical vein endothelial cells (HUVEC). The role of Trp proteins in store regulation of endothelial membrane conductances was tested by expression of an N‐terminal fragment of hTrp3 (N‐TRP) which exerts a dominant negative effect on Trp channel function presumably due to suppression of channel assembly. Depletion of intracellular Ca 2+ stores with IP 3 (100 μM) or thapsigargin (100 nM) induced a substantial cation conductance in sham‐transfected HUVEC as well as in HUVEC transfected with hTrp3. In contrast, HUVEC transfected with N‐TRP failed to exhibit store‐operated currents. Our results suggest the involvement of Trp related proteins in the store‐operated cation conductance of human vascular endothelial cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Reactive Oxygen Species in Inflammation and Tissue Injury
Mittal, M., Siddiqui, M. R., Tran, K., Reddy, S. P., & Malik, A. B. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.5149 · Cited by 4,897
The TRP Superfamily of Cation Channels
Montell, C. (2005) · Science's STKE · doi:10.1126/stke.2722005re3 · Cited by 989
Ion Channels and Their Functional Role in Vascular Endothelium
Nilius, B., & Droogmans, G. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.4.1415 · Cited by 868
Li, Y., Jia, Y.-C., Cui, K., Li, N., Zheng, Z.-Y., Wang, Y.-Z., & Yuan, X.-B. (2005) · Nature · doi:10.1038/nature03477 · Cited by 450
Transient Receptor Potential Channels in the Vasculature
Earley, S., & Brayden, J. E. (2015) · Physiological Reviews · doi:10.1152/physrev.00026.2014 · Cited by 420
Metadata
- Authors
- Groschner, K., Hingel, S., Lintschinger, B., Balzer, M., Romanin, C., Zhu, X., & Schreibmayer, W.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1998-10-16
- Volume
- 437
- Issue
- 1-2
- Pages
- 101-106
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2059674419
- Cited by
- 161
- References
- 0
- FWCI
- 6.29
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Trp proteins form store‐operated cation channels in human vascular endothelial cells. https://app.cochat.ai/papers/10.1016/s0014-5793(98)01212-5
- The paper
- Groschner, K., Hingel, S., Lintschinger, B., Balzer, M., Romanin, C., Zhu, X., & Schreibmayer, W. (1998). Trp proteins form store‐operated cation channels in human vascular endothelial cells. FEBS Letters. https://doi.org/10.1016/s0014-5793(98)01212-5
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
