The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-κB activation at the level of TRAF6
Open accessAbstract
The zinc finger protein A20 is encoded by an immediate early response gene whose expression is induced by different inflammatory stimuli, including interleukin‐1 (IL‐1). Gene induction by IL‐1 is mediated by activation of the transcription factor NF‐κB, and requires the signal adapter protein TRAF6. The latter interacts with the NF‐κB‐inducing kinase NIK, which is believed to be part of the IκB kinase complex. Expression of A20 potently inhibits IL‐1‐induced NF‐κB activation by an unknown mechanism. Inhibition of IL‐1‐induced NF‐κB activation was found to be mediated by the C‐terminal zinc finger‐containing domain of A20. More importantly, we present evidence that A20 interferes with IL‐1‐induced NF‐κB activation at the level of TRAF6, upstream of NIK. Moreover, A20 was shown to directly interact with TRAF6.
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“Nuclear factor-B is involved in the gene expression of TNF-␣ and IL-1 in monocytes and macrophages in humans and HL-60 cells, and the effect of zinc in inhibiting the gene expression of TNF-␣ and IL-1 is cell specific (20 -25).”
From Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress (2007) · cites this paper as [23]
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A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
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IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation
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TRAF6 is a signal transducer for interleukin-1
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IL-17 Signaling Triggers Degradation of the Constitutive NF-κB Inhibitor ABIN-1
Cruz, J. A., Childs, E. E., Amatya, N., Garg, A. V., Beyaert, R., Kane, L. P., Aneskievich, B. J., Ma, A., & Gaffen, S. L. (2017) · ImmunoHorizons · doi:10.4049/immunohorizons.1700035 · Cited by 29
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Metadata
- Authors
- Heyninck, K., & Beyaert, R.
- Affiliations
- Vlaams Instituut voor Biotechnologie (BE)
- Corresponding author
- Beyaert, Rudi
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1999-01-15
- Volume
- 442
- Issue
- 2-3
- Pages
- 147-150
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2054142977
- Cited by
- 169
- References
- 28
- Citations by year
- 2024: 2 · 2023: 4 · 2022: 2 · 2021: 3 · 2020: 7 · 2019: 9 · 2018: 5 · 2017: 8 · 2016: 5 · 2015: 4 · 2014: 12 · 2013: 8 · 2012: 12
- FWCI
- 3.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Funders
- Vlaamse regering
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- A20, zinc finger proteins, interleukin-1, NF-κB activation, TRAF6, NIK, IκB kinase complex, protein-protein interaction, cytokine-induced gene expression
- MeSH terms
- Tumor Necrosis Factor alpha-Induced Protein 3, NF-kappaB-Inducing Kinase, Cell Line, DNA-Binding Proteins, Gene Expression Regulation, Humans, Interleukin-1, Kidney, Nuclear Proteins, Precipitin Tests, Proteins, Transfection, Tumor Necrosis Factor-alpha, Blotting, Western, Signal Transduction, Transcriptional Activation, NF-kappa B, Zinc Fingers, Protein Serine-Threonine Kinases, Sequence Deletion, Intracellular Signaling Peptides and Proteins, TNF Receptor-Associated Factor 1, TNF Receptor-Associated Factor 2, TNF Receptor-Associated Factor 6
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