The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
UCP4, a novel brain‐specific mitochondrial protein that reduces membrane potential in mammalian cells
Abstract
Uncoupling proteins (UCPs) are a family of mitochondrial transporter proteins that have been implicated in thermoregulatory heat production and maintenance of the basal metabolic rate. We have identified and partially characterized a novel member of the human uncoupling protein family, termed uncoupling protein‐4 (UCP4). Protein sequence analyses showed that UCP4 is most related to UCP3 and possesses features characteristic of mitochondrial transporter proteins. Unlike other known UCPs, UCP4 transcripts are exclusively expressed in both fetal and adult brain tissues. UCP4 maps to human chromosome 6p11.2–q12. Consistent with its potential role as an uncoupling protein, UCP4 is localized to the mitochondria and its ectopic expression in mammalian cells reduces mitochondrial membrane potential. These findings suggest that UCP4 may be involved in thermoregulatory heat production and metabolism in the brain.
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Cited by
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Metadata
- Authors
- Mao, W., Yu, X. X., Zhong, A., Li, W., Brush, J., Sherwood, S. W., Adams, S. H., & Pan, G.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 1999-01-29
- Volume
- 443
- Issue
- 3
- Pages
- 326-330
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1976748679
- Cited by
- 377
- References
- 25
- FWCI
- 11.09
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mao, W., Yu, X. X., Zhong, A., Li, W., Brush, J., Sherwood, S. W., Adams, S. H., & Pan, G. (1999). UCP4, a novel brain‐specific mitochondrial protein that reduces membrane potential in mammalian cells. FEBS Letters. https://doi.org/10.1016/s0014-5793(98)01713-x
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