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The allosteric ATP‐inhibition of cytochrome c oxidase activity is reversibly switched on by cAMP‐dependent phosphorylation
Open accessAbstract
In previous studies the allosteric inhibition of cytochrome c oxidase at high intramitochondrial ATP/ADP‐ratios via binding of the nucleotides to the matrix domain of subunit IV was demonstrated. Here we show that the allosteric ATP‐inhibition of the isolated bovine heart enzyme is switched on by cAMP‐dependent phosphorylation with protein kinase A of subunits II (and/or III) and Vb, and switched off by subsequent incubation with protein phosphatase 1. It is suggested that after cAMP‐dependent phosphorylation of cytochrome c oxidase mitochondrial respiration is controlled by the ATP/ADP‐ratio keeping the proton motive force Δ p low, and the efficiency of energy transduction high. After Ca 2+‐induced dephosphorylation this control is lost, accompanied by increase of Δ p, slip of proton pumping (decreased H+/e− stoichiometry), and increase of the rate of respiration and ATP‐synthesis at a decreased efficiency of energy transduction.
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Cited by
Bonora, M., Patergnani, S., Rimessi, A., De Marchi, E., Suski, J. M., Bononi, A., Giorgi, C., Marchi, S., Missiroli, S., Poletti, F., et al. (2012) · Purinergic Signalling · doi:10.1007/s11302-012-9305-8 · Cited by 644
Stump, C. S., Short, K. R., Bigelow, M. L., Schimke, J. M., & Nair, K. S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1332551100 · Cited by 477
Cytochrome c oxidase dysfunction in oxidative stress
Srinivasan, S., & Avadhani, N. G. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.07.021 · Cited by 373
Regulation of ATP production by mitochondrial Ca2+
Tarasov, A. I., Griffiths, E. J., & Rutter, G. A. (2012) · Cell Calcium · doi:10.1016/j.ceca.2012.03.003 · Cited by 319
Lenaz, G., & Genova, M. L. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2704 · Cited by 260
Metadata
- Authors
- Bender, E., & Kadenbach, B.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2000-01-18
- Volume
- 466
- Issue
- 1
- Pages
- 130-134
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2050688382
- Cited by
- 197
- References
- 0
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bender, E., & Kadenbach, B. (2000). The allosteric ATP‐inhibition of cytochrome c oxidase activity is reversibly switched on by cAMP‐dependent phosphorylation. FEBS Letters. https://doi.org/10.1016/s0014-5793(99)01773-1
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