The use of clomiphene citrate
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Two hundred and fifty-five women received clomiphene citrate during a 10-year period. Fifty-six were treated diagnostically and one hundred and ninty-nine therapeutically for infertility. It is concluded that clomiphene may aid in confirming the diagnosis and establishing a prognosis in patients with primary or secondary amenorrhea. The success of clomiphene therapy in patients with anovulatory infertility is related to the etiologic factor responsible for the anovulation, but results can be improved by adjustment of the therapeutic regimen used. In the present series, 48% of the patients who ovulated became pregnant, and 25.3% of the pregnancies were miscarried. Those patients who ovulated spontaneously and became pregnant after having discontinued clomiphene therapy showed only a 10% abortion rate. A review of the results indicates that both the ovulation rate and the pregnancy rate can be improved if adjustments are made in therapy to ensure normal follicular maturation and corpus luteum function.
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Clomiphene results in a 60%-85% ovulation rate and a 10%-20% pregnancy rate per cycle.
“Clomiphene results in a 60%-85% ovulation rate and a 10%-20% pregnancy rate per cycle (2)(3)(4)(5)(6)(7)(8).”
From A randomized double-blind comparison of the effects of clomiphene citrate and the aromatase inhibitor letrozole on ovulatory function in normal women (2002) · cites this paper as [3]
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References 10 · Cited by 233
- Authors
- Garcia, J., Jones, G. S., & Wentz, A. C.
- Affiliations
- Johns Hopkins University (US)
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 1977-07
- Volume
- 28
- Issue
- 7
- Pages
- 707-717
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W125278432
- Cited by
- 233
- References
- 10
- Citations by year
- 2024: 2 · 2023: 3 · 2022: 3 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 3 · 2012: 1
- FWCI
- 4.98
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- clomiphene citrate, anovulatory infertility, amenorrhea, ovulation induction, pregnancy rate, miscarriage, spontaneous ovulation, follicle maturation, luteal function
- MeSH terms
- Abortion, Spontaneous, Adolescent, Adult, Amenorrhea, Anovulation, Clomiphene, Female, Chorionic Gonadotropin, Humans, Infertility, Female, Luteal Phase, Maryland, Menstruation, Menstruation Disturbances, Oligomenorrhea, Pregnancy, Progesterone, Prognosis, Suppositories, Vagina
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