The natural killer activity of peritoneal fluid lymphocytes is decreased in women with endometriosis
Open accessAbstract
Objective To investigate the local natural killer (NK) activity of the peritoneal fluid mononuclear cells (PFMC). DESIGN PATIENTS: In a prospective way, the NK activity (K562-assay) was measured in peripheral blood (PB) and peritoneal fluid (PF) of 44 women who underwent a laparoscopy for infertility and/or pain at the University Hospital of Gasthuisberg, Leuven, Belgium.Main outcome measure The NK activity of peripheral blood mononuclear cells and PFMC, the number and concentration of PFMC, the percentage of lymphocytes versus macrophages by May-Grünwald-Giemsa staining and the estradiol and progesterone concentration of the PF were correlated together and with the severity of endometriosis.Results We demonstrated that there is a significant NK activity in PF and that this activity is decreased in women with endometriosis. This defect was more pronounced in the follicular phase of the cycle compared with the postovulatory phase. In PB of the same 44 women, the decreased NK activity correlated with the severity of the disease. This confirms our previous report on another 34 women.Conclusions The NK activity is decreased in women with endometriosis and correlated significantly with the severity of the disease in both the PB and PF of women with endometriosis.
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Natural killer activity is decreased in peritoneal fluid and in plasma of women with endometriosis, and after excision of deep endometriosis their activity remains low, whereas elevated CA-125 concentrations return to normal.
“The natural killer activity is decreased in PF and in plasma of women with endometriosis (103-105) and after excision of deep endometriosis their activity remains low, whereas elevated CA-125 concentrations return to normal (106).”
From Pathogenesis of deep endometriosis (2017) · cites this paper as [104]
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References 21 · Cited by 242
- Authors
- Oosterlynck, D. J., Meuleman, C., Waer, M., Vandeputte, M., & Koninckx, P. R.
- Affiliations
- Rega Institute for Medical Research (BE)
- ORCID
- Meuleman, Christel
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 1992-08
- Volume
- 58
- Issue
- 2
- Pages
- 290-295
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W2417327597
- Cited by
- 242
- References
- 21
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 9 · 2023: 4 · 2022: 11 · 2021: 7 · 2020: 9 · 2019: 6 · 2018: 2 · 2017: 8 · 2016: 9 · 2015: 6 · 2014: 9 · 2013: 3 · 2012: 1
- FWCI
- 8.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- endometriosis, natural killer cells, NK cell cytotoxicity, endometriosis severity, menstrual cycle phases, follicular phase, peripheral blood mononuclear cells, estradiol, progesterone, infertility, dysmenorrhea
- MeSH terms
- Ascitic Fluid, Endometriosis, Female, Humans, Killer Cells, Natural, Leukocytes, Mononuclear, Menstrual Cycle, Prospective Studies
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