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Assisted hatching facilitates earlier implantation

Liu, Hung-Ching, Cohen, Jacques, Alikani, Mina, Noyes, Nicole, Rosenwaks, Zev·1993·Fertility and Sterility
DOI 10.1016/s0015-0282(16)56289-x
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Abstract

Objective To examine whether opening of the zona pellucida (i.e., assisted hatching) accelerates implantation. Design In a controlled, randomized trial, patients were assigned to control and assisted hatching groups. Setting All patients studied were of the Center for Reproductive Medicine at Cornell University Medical College. Intervention All patients underwent stimulation with gonadotropins after luteal phase GnRH down regulation. Assisted hatching with zona drilling using acidic Tyrode's solution was performed on the assigned embryos. Main outcome measures Luteal E2, P, and hCG on days +5, +6, +7, +8, +9, +11, +13, and +15 were measured. The implantation time, peak midluteal E2 and intervals between these two values were studied. Results Implantation occurred significantly earlier in the assisted hatching group. The interval between implantation and peak midluteal E2 was also significantly shorter in the assisted hatching group than in the controls. However, there was no significant difference in the day of the peak midluteal E2 between the assisted hatching and control groups. Conclusion Assisted hatching may enhance embryo implantation not only by mechanically facilitating the hatching process but also by allowing earlier embryo-endometrium contact. Such early contact may enhance embryonic development potential and may optimize synchronization between embryo and endometrium, resulting in improved implantation efficiency.

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Crossref · 10.1016/s0015-0282(16)56289-x

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  • In one of the largest studies of in vitro fertilization, implantation was reported in relation to egg retrieval for 140 clinical pregnancies, and implantation was detected 6 to 13 days after egg retrieval.

    “In one of the largest studies, implantation was reported in relation to egg retrieval for 140 clinical pregnancies in which conception occurred in vitro.27 Implantation was detected 6 to 13 days after egg retrieval.”

    From Time of Implantation of the Conceptus and Loss of Pregnancy (1999) · cites this paper as [27]

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Research works printed but not linked: 23

  1. Liu, 1993, Recent advances to improve human implantation, Asst Reprod Technol Androl, 4, 51
  2. Liu, 1988, Mechanisms and factors of early pregnancy wastage in in vitro fertilization-embryo transfer patients, Fertil Steril, 50, 95, 10.1016/S0015-0282(16)60015-8 · DOI
  3. Liu, 1992, Improved pregnancy outcome with gonadotropin releasing hormone agonist (GnRH-a) stimulation is due to the improvement in oocyte quantity rather than quality, J Asst Reprod Genet, 9, 338, 10.1007/BF01203956 · DOI
  4. Bongso, 1990, Co-cultures: their relevance to assisted reproduction, Hum Reprod, 5, 893, 10.1093/oxfordjournals.humrep.a137216 · DOI
  5. Bongso, 1991, Cocultures: a new lead in embryo quality improvement for assisted reproduction, Fertil Steril, 56, 179, 10.1016/S0015-0282(16)54468-9 · DOI
  6. Bongso, 1991, Co-cultures in human assisted reproduction: support of embryos in vitro and their specificity, Ann NY Acad Sci, 626, 438, 10.1111/j.1749-6632.1991.tb37935.x · DOI
  7. Menezo, 1990, Improvement of human embryo development in vitro by coculture on monolayers of Vero cells, Biol Reprod, 42, 301, 10.1095/biolreprod42.2.301 · DOI
  8. Wiemer, 1989, Coculture of human zygotes on fetal bovine uterine fibroblasts: morphology and implantation, Fertil Steril, 52, 503, 10.1016/S0015-0282(16)60926-3 · DOI
  9. Bongso, 1992, Improved pregnancy rate after transfer of embryos grown in human fallopian tubal cell coculture, Fertil Steril, 58, 569, 10.1016/S0015-0282(16)55265-0 · DOI
  10. Cohen, 1990, Immunosuppression supports implantation of zona pellucida dissected human embryos, Fertil Steril, 53, 662, 10.1016/S0015-0282(16)53460-8 · DOI
  11. Cohen, 1991, Partial zona dissection or subzonal sperm insertion: microsurgical fertilization alternatives based on evaluation of sperm and embryo morphology, Fertil Steril, 56, 696, 10.1016/S0015-0282(16)54602-0 · DOI
  12. Alikani, 1992, Subzonal sperm insertion and the frequency of gamete fusion, J Asst Reprod Genet, 9, 97, 10.1007/BF01203746 · DOI
  13. Cohen, 1992, Implantation enhancement by selective assisted hatching using zona drilling of human embryos with poor prognosis, Hum Reprod, 7, 685, 10.1093/oxfordjournals.humrep.a137720 · DOI
  14. Cohen, 1991, Assisted hatching of human embryos, J In Vitro Fert Embryo Transf, 8, 179, 10.1007/BF01130802 · DOI
  15. Cohen, 1990, Impairment of the hatching process following IVF in the human and improvement of implantation by assisting hatching using micromanipulation, Hum Reprod, 5, 7, 10.1093/oxfordjournals.humrep.a137044 · DOI
  16. Malter, 1989, Blastocyst formation and hatching in vitro following zona drilling of mouse and human embryos, Gamete Res, 24, 67, 10.1002/mrd.1120240110 · DOI
  17. Cohen, 1991, Effects of the size and number of zona pellucida openings on hatching and trophoblast outgrowth in the mouse embryo, Mol Reprod Dev, 30, 70, 10.1002/mrd.1080300110 · DOI
  18. Neev, 1993, A contact-free microscope-delivered laser ablation system for assisted hatching of the mouse embryo without the use of a micromanipulator, Hum Reprod, 8, 939, 10.1093/oxfordjournals.humrep.a138171 · DOI
  19. Khalifa, 1992, Cruciate thinning of the zona pellucida for more successful enhancement of blastocyst hatching in the mouse, Hum Reprod, 7, 532, 10.1093/oxfordjournals.humrep.a137685 · DOI
  20. Cohen, 1992, Selective assisted hatching of human embryos, Ann Acad Med Singapore, 21, 565
  21. Liu, 1988, The efficiency of human reproduction after in vitro fertilization and embryo transfer, Fertil Steril, 49, 649, 10.1016/S0015-0282(16)59834-3 · DOI
  22. Liu, 1990, Early pregnancy wastage in IVF (in vitro fertilization) patients, J IVF/ET, 8, 65
  23. Liu, 1988, Mechanisms and factors of early pregnancy wastage in in vitro fertilization-embryo transfer patients, Fertil Steril, 50, 95, 10.1016/S0015-0282(16)60015-8 · DOI

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Metadata

Authors
Liu, H.-C., Cohen, J., Alikani, M., Noyes, N., & Rosenwaks, Z.
Venue
Fertility and Sterility
Publisher
Elsevier BV
Published
1993-11
Volume
60
Issue
5
Pages
871-875
ISSN
0015-0282
DOI
10.1016/s0015-0282(16)56289-x
Cited by
81
References
0
Language
en
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