Combined (hormonal and microsurgical) therapy in infertile women with endometriosis
Open accessAbstract
Fifty patients with moderate or severe endometriosis received 5 mg/day lynestrenol for 6 months prior to microsurgery. A significant regression of the ovarian and peritoneal implants was observed in 72% of the cases after progestative treatment, but the presence of residual epithelium in all cases made surgical resection necessary. After preoperative medical treatment and microsurgery, intrauterine (living births) pregnancy rates of 60 and 47% were obtained in cases of moderate and severe endometriosis, respectively. The following prognostic factors were found in this series: the degree of endometriosis, the concomitant male factors, the decrease of endometriotic lesions after treatment, and the unilaterality of ovarian endometriosis.
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Some studies have revealed absence of proliferation index changes under progestogen therapy.
“Some studies have revealed the absence of proliferation index changes under progestogen therapy [77,78,79,80,81].”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [77]
The impact of progestogens on morphology and vascularization of ectopic endometrial tissue and atrophy is questionable.
“the impact of progestogens on the morphology and vascularization of ectopic endometrial tissue and atrophy is much more questionable [77,78,79,80,81].”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [77]
The reduction in lesion volume with estroprogestins or progestins is not predictable and not significant in the vast majority of cases.
“The reduction in lesion volume is not predictable and not significant in the vast majority of cases. Conflicting results have been observed [77,78,79,80,81,82,86,87,88].”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [77]
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References 16 · Cited by 54
- Authors
- Donnez, J., Lemaire-Rubbers, M., Karaman, Y., Nisolle-Pochet, M., & Casanas-Roux, F.
- Affiliations
- UCLouvain (BE)
- ORCID
- Donnez, Jacques
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 1987-08
- Volume
- 48
- Issue
- 2
- Pages
- 239-242
- ISSN
- 0015-0282 (ISSN-L)
- OpenAlex
- W1792454541
- Cited by
- 54
- References
- 16
- Citations by year
- 2026: 1 · 2021: 1 · 2020: 1 · 2017: 2 · 2015: 2 · 2013: 1 · 2012: 1
- FWCI
- 4.35
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (submittedVersion)
- Open Repository and Bibliography (University of Liège) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis, female infertility, combined hormonal therapy, lynestrenol, progestin therapy, microsurgical resection, endometrioma, peritoneal endometriosis, pregnancy rate, prognostic factors, male factor infertility
- MeSH terms
- Adult, Body Weight, Combined Modality Therapy, Dyspareunia, Endometriosis, Female, Humans, Infertility, Female, Lynestrenol, Microsurgery, Pain, Premedication, Prospective Studies
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