CoChat
Sign Up
Cited by 37Liver Disease and TransplantationDrug Transport and Resistance MechanismsLiver physiology and pathology

The DOI matches its Crossref record; the references it cites are not checked yet.

Determinants of Serum Bile Acids in Chronic Liver Disease

Open access
Paré, Pierre, Hoefs, John C., Ashcavai, Mary·1981·Gastroenterology
DOI 10.1016/s0016-5085(81)80125-4
Open this paper in CoChat — free account

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/s0016-5085(81)80125-4

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • A discrepancy between serum and hepatic BA levels occurs during cholestasis secondary to either reduced hepatic BA extraction efficiency in the enterohepatic loop or portosystemic shunts.

    “Such a discrepancy is known to occur during cholestasis secondary to either reduced hepatic BA extraction efficiency in the enterohepatic loop or due to portosystemic shunts.28,29”

    From Constitutive Androstane Receptor Regulates Bile Acid Homeostasis and Metabolism During Liver Regeneration (2026) · cites this paper as [29]

    The Discussion says that reduced hepatic extraction and extrahepatic shunting can increase peripheral serum bile acids in chronic liver disease. However, the study measured bile acids in portal, hepatic, and peripheral venous blood in patients with alcoholic liver disease; it does not establish a discrepancy between serum and hepatic tissue bile-acid levels specifically during cholestasis. Page numbers are unavailable in our copy. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

The citation lists haven’t been fetched yet

References 30 · Cited by 37

Research works printed but not linked: 29

  1. Korman, 1974, Assessment of activity in chronic active liver disease: serum bile acids compared with conventional tests and histology, N Engl J Med, 290, 1399, 10.1056/NEJM197406202902503 · DOI
  2. Barnes, 1975, Diagnostic value of serum bile acid estimations in liver disease, J Clin Pathol, 28, 506, 10.1136/jcp.28.6.506 · DOI
  3. Hirayama, 1976, Diagnostic significance of fasting serum bile acid in liver disease, Acta Hepato-Gastroenterol, 23, 385
  4. Milstein, 1976, Serum bile acids in alcoholic liver disease. Comparison with histological features of the disease, Dig Dis, 21, 281, 10.1007/BF01071839 · DOI
  5. Pennington, 1977, Serum bile acids in the diagnosis of hepatobiliary disease, Gut, 18, 903, 10.1136/gut.18.11.903 · DOI
  6. Osuga, 1977, Evaluation of fluorometrically estimated serum bile acid in liver disease, Clin Chim Acta, 75, 81, 10.1016/0009-8981(77)90502-2 · DOI
  7. Kaplowitz, 1973, Postprandial serum bile acid for the detection of hepatobiliary disease, JAMA, 225, 292, 10.1001/jama.1973.03220300048011 · DOI
  8. Boyer, 1977, Direct transhepatic measurement of portal vein pressure using a thin needle. Comparison with wedged hepatic vein pressure, Gastroenterology, 72, 584, 10.1016/S0016-5085(77)80136-4 · DOI
  9. Ware, 1952, An improved one-stage prothrombin method, Am J Clin Pathol, 22, 791, 10.1093/ajcp/22.8_ts.791 · DOI
  10. Mashige, 1976, A simple and sensitive assay of total serum bile acids, Clin Chim Acta, 70, 79, 10.1016/0009-8981(76)90007-3 · DOI
  11. LaRusso, 1974, Dynamics of the enterohepatic circulation of bile acids, N Engl J Med, 291, 689, 10.1056/NEJM197410032911401 · DOI
  12. La Russo, 1978, Determinants of fasting and postprandial serum bile acid levels in healthy man, Am J Dig Dis, 23, 385, 10.1007/BF01072919 · DOI
  13. Vlahcevic, 1977, Disturbances of bile acid metabolism in parenchymal liver cell disease, Clin Gastroenterol, 6, 25, 10.1016/S0300-5089(21)00384-9 · DOI
  14. Stiehl, 1978, Pool size, synthesis, and turnover of sulfated and non sulfated cholic acid and chenodeoxycholic acid in patients with cirrhosis of the liver, Gastroenterology,, 74, 575, 10.1016/0016-5085(78)90298-6 · DOI
  15. Stiehl, 1975, Sulfation and renal excretion of bile salts in patients with cirrhosis of the liver, Gastroenterology, 68, 534, 10.1016/S0016-5085(75)80093-X · DOI
  16. Makino, 1975, Sulfated and nonsulfated bile acids in urine, serum acid bile of patients with hepatobiliary disease, Gastroenterology, 68, 545, 10.1016/S0016-5085(75)80094-1 · DOI
  17. Van Berge Henegouwen, 1976, Sulphated and unsulphated bile acids in serum, bile and urine of patients with cholestasis, Gut, 17, 861, 10.1136/gut.17.11.861 · DOI
  18. Ahlberg, 1977, Individual bile acids in portal venous and systemic blood serum of fasting man, Gastroenterology, 73, 1377, 10.1016/S0016-5085(19)31517-3 · DOI
  19. Makino, 1969, Conjugated and unconjugated serum bile acid levels in patients with hepatobiliary diseases, Gastroenterology, 56, 1033, 10.1016/S0016-5085(69)80004-1 · DOI
  20. Lindblad, 1977, Bile acid concentrations in systemic and portal serum in presumably normal man and in cholestatic and cirrhotic conditions, Scand J Gastroenterol, 12, 395, 10.3109/00365527709181679 · DOI
  21. Reichen, 1976, Uptake of bile acids by perfused rat liver, Am J Physiol, 231, 734, 10.1152/ajplegacy.1976.231.3.734 · DOI
  22. Glasinovic, 1975, Hepatocellular uptake of taurocholate in the dog, J Clin Invest, 55, 41926
  23. Reichen, 1976, Kinetics of taurocholate uptake by the perfused rat liver, Gastroenterology, 68, 132, 10.1016/S0016-5085(75)80057-6 · DOI
  24. O'Maille, 1967, The influence of conjugation of cholic acid on its uptake and secretion: hepatic extraction of taurocholate and cholate in the dog, J Physiol, 189, 337, 10.1113/jphysiol.1967.sp008172 · DOI
  25. Cowen, 1975, Plasma disappearance of radioactivity after intravenous injection of labeled bile acids in man, Gastroenterology, 68, 1567, 10.1016/S0016-5085(75)80146-6 · DOI
  26. Shaffer, 1978, Serum bile acids as related to bile acid secretion in liver disease, Am J Dig Dis, 23, 392, 10.1007/BF01072920 · DOI
  27. Schwartz, 1979, Bile acid metabolism in cirrhosis. V. Determination of biliary lipid secretion rates in patients with advanced cirrhosis, Gastroenterology, 77, 1177, 10.1016/0016-5085(79)90154-9 · DOI
  28. Huet, 1979, Hepatocellular uptake of cholylglycine (CG) in cirrhosis (abstr), Gastroenterology, 76, 1285
  29. Cowen, 1975, Metabolism of lithocholate in healthy man. II. Enterohepatic circulation, Gastroenterology, 69, 67, 10.1016/S0016-5085(19)32637-X · DOI

Metadata

Authors
Paré, P., Hoefs, J. C., & Ashcavai, M.
Affiliations
University of Southern California (US)
Venue
Gastroenterology
Publisher
Elsevier BV
Published
1981-11
Volume
81
Issue
5
Pages
959-964
ISSN
0016-5085 (ISSN-L)
DOI
10.1016/s0016-5085(81)80125-4
OpenAlex
W2138146065
Cited by
37
References
30
Citations by year
2026: 1 · 2025: 1 · 2018: 1
FWCI
3.96
Type
journal article
Language
en
Open access
Licence
Locations
  • Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Medical Research Council Canada
  • Medical Research Council
Topics
  • Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Keywords
serum bile acids, chronic liver disease, alcoholic liver disease, enterohepatic circulation, cholecystokinin, gallbladder emptying, prothrombin time, cholylglycine, hepatic vein catheterization
MeSH terms
Bile Acids and Salts, Cholecystokinin, Glycocholic Acid, Humans, Lithocholic Acid, Liver, Liver Circulation, Liver Diseases, Alcoholic, Portal Vein

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review