Cited by 189Helicobacter pylori-related gastroenterology studiesInflammatory mediators and NSAID effectsImmune Response and Inflammation

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Helicobacter pylori stimulates inducible nitric oxide synthase expression and activity in a murine macrophage cell line

Open access

Wilson, KT, Ramanujam, KS, Mobley, HL, Musselman, RF, James, SP, Meltzer, SJ·1996·Gastroenterology

DOI 10.1016/s0016-5085(96)70014-8

Open this paper in CoChat — free account

Abstract

Background & aims Helicobacter pylori uniquely colonizes the human stomach and produces gastric mucosal inflammation. High-output nitric oxide production by inducible nitric oxide synthase (iNOS) is associated with immune activation and tissue injury. Because mononuclear cells comprise a major part of the cellular inflammatory response to H. pylori infection, the ability of H. pylori to induce iNOS in macrophages was assessed.Methods H. pylori preparations were added to RAW 264.7 murine macrophages, and iNOS expression was assessed by Northern blot analysis, enzyme activity assay, and NO2- release.Results Both whole H. pylori and French press lysates induced concentration-dependent NO2- production, with peak levels 20-fold above control. These findings were paralleled by marked increases in iNOS messenger RNA and enzyme activity levels. iNOS expression was synergistically increased with interferon gamma, indicating that the H. pylori effect can be amplified by other macrophage-activating factors. Studies of lipopolysaccharide (LPS) content and polymyxin B inhibition of LPS suggested that the H. pylori effect was attributable to both LPS-dependent and -independent mechanisms.Conclusions iNOS expression in macrophages is activated by highly stable H. pylori products and may play an important role in the pathogenesis of H. pylori-associated gastric mucosal disease.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/s0016-5085(96)70014-8

Cites

6 of 6 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Peroxynitrite oxidation of sulfhydryls.
Radí, R., Beckman, J. S., Bush, K., & Freeman, B. Α. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)64313-7 · Cited by 2,492
Amelioration of chronic ileitis by nitric oxide synthase inhibition.
Miller, M. J., Sadowska-Krowicka, H., Chotinaruemol, S., Kakkis, J. L., & Clark, D. A. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)10238-3 · Cited by 407
Nitric Oxide Synthase Is Not a Constituent of the Antimicrobial Armature of Human Mononuclear Phagocytes
Schneemann, M., Schoedon, G., Hofer, S., Blau, N., Guerrero, L., & Schaffner, A. (1993) · The Journal of Infectious Diseases · doi:10.1093/infdis/167.6.1358 · Cited by 333
Helicobacter pylori infection density and gastric inflammation in duodenal ulcer and non-ulcer subjects.
Khulusi, S., Mendall, M. A., Patel, P., Levy, J., Badve, S., & Northfield, T. C. (1995) · Gut · doi:10.1136/gut.37.3.319 · Cited by 116
Adherence and internalization of Helicobacter pylori by HEp-2 cells
Evans, D. G., Evans, D. J., & Graham, D. Y. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)91714-f · Cited by 111
Helicobacter pylori and Gastric Carcinoma
Shimizu, N., Tatematsu, M., & Kaminishi, M. (2006) · Springer eBooks · doi:10.1007/4-431-27713-7_4 · Cited by 25

Show all 6 references

Research works printed but not linked: 19

Sherman PA, Laubach VE, Reep BR, Wood ER. Purification and 1. Whittle BJ, Lopez-Belmonte J, Moncada S. Regulation of gastric cDNA sequence of an inducible nitric oxide synthase from a hu- mucosal integrity by endogenous nitric oxide: interactions with man tumor cell line. Biochemistry 1993;32:11600-11605. prostanoids and sensory neuropeptides in the rat. Br J Pharmacol 22. Tepperman BL, Brown JF, Whittle BJ. Nitric oxide synthase induc- 1990;99:607-611. tion and intestinal epithelial cell viability in rats. Am J Physiol 2. Miller MJ, Sadowska-Krowicka H, Chotinaruemol S, Kakkis JL, 1993;265:G214-G218.
Xie QW, Cho HJ, Calaycay J, Mumford RA, Swiderek KM, Lee 4. Boughton-Smith NK, Evans SM, Hawkey CJ, Cole AT, Balsitis M, TD, Ding A, Troso T, Nathan C. Cloning and characterization of Whittle BJ, Moncada S. Nitric oxide synthase activity in ulcerative inducible nitric oxide synthase from mouse macrophages. Sci- colitis and Crohn's disease. Lancet 1993;342:338-340. ence 1992;256:225-228.
Mills SD, Kurjanczyk LA, Penner JL. Antigenicity of Helicobacter 5. Boughton-Smith NK, Evans SM, Whittle BJ, Moncada S. Induction of nitric oxide synthase in rat intestine and its association with pylori lipopolysaccharides. J Clin Microbiol 1992;30:3175- 3180. tissue injury. Agents Actions 1993;38:C125-C126. / 5e14$$0038 11-13-96 19:03:14 gasa WBS-Gastro
Westphal O, Jann K. Bacterial lipopolysaccharides: extraction Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 1995;81:641- with phenol-water and further applications of the procedure. Methods Carbohydr Chem 1965;5:83-91. 650.
Blaser MJ, Parsonnet J. Parasitism by the ''slow'' bacterium 27. Hochstein HD, Mills DF, Outschoorn AS, Rastogi SC. The pro- cessing and collaborative assay of a reference endotoxin. J Biol Helicobacter pylori leads to altered gastric homeostasis and neo- plasia. J Clin Invest 1994;94:4-8. Stand 1983;11:251-260.
Fox JG, Blanco M, Murphy JC, Taylor NS, Lee A, Kabok Z, Pappo 45. Birkholz S, Knipp U, Nietzki C, Adamek RJ, Opferkuch W. Immuno- logical activity of lipopolysaccharide of Helicobacter pylori on hu- J. Local and systemic immune responses in murine Helicobacter felis active chronic gastritis. Infect Immun 1993;61:2309- man peripheral mononuclear blood cells in comparison to lipo- polysaccharides of other intestinal bacteria. FEMS Immunol Med 2315.
Xie QW, Whisnant R, Nathan C. Promoter of the mouse gene Microbiol 1993;6:317-324.
Mattsby-Baltzer I, Mielniczuk Z, Larsson L, Lindgren K, Goodwin encoding calcium-independent nitric oxide synthase confers in- ducibility by interferon gamma and bacterial lipopolysaccharide. S. Lipid A in Helicobacter pylori. Infect Immun 1992;60:4383- 4387. J Exp Med 1993;177:1779-1784.
Russell SW, Murphy WJ. Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma 1992;186:775-781.
Schneemann M, Schoedon G, Hofer S, Blau N, Guerrero L, Schaff- and lipopolysaccharide. Proc Natl Acad Sci USA 1993;90:9730- 9734.
Dumarey CH, Labrousse V, Rastogi N, Vargaftig BB, Bachelet M. phages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide. J Biol Selective Mycobacterium avium-induced production of nitric oxide by human monocyte-derived macrophages. J Leukoc Biol 1994; Chem 1993;268:1908-1913.
Vouldoukis I, Riveros-Moreno V, Dugas B, Ouaaz F, Becherel P, Helicobacter pylori urease at wild-type levels in Escherichia coli. Infect Immun 1993;61:2563-2569.
Debre P, Moncada S, Mossalayi MD. The killing of Leishmania major by human macrophages is mediated by nitric oxide induced 33. Muotiala A, Helander IM, Pyhala L, Kosunen TU, Moran AP. Low biological activity of Helicobacter pylori lipopolysaccharide. Infect after ligation of the Fc epsilon RII/CD23 surface antigen. Proc Natl Acad Sci USA 1995;92:7804-7808. Immun 1992;60:1714-1716.
Issekutz AC. Removal of gram-negative endotoxin from solutions 51. Paul-Eugene N, Mossalayi D, Sarfati M, Yamaoka K, Aubry JP, Bonnefoy JY, Dugas B, Kolb JP. Evidence for a role of Fc epsilon by affinity chromatography. J Immunol Methods 1983;61:275- 281. RII/CD23 in the IL-4-induced nitric oxide production by normal human mononuclear phagocytes. Cell Immunol 1995;163:314- 35.
Ohshima H, Bartsch H. Chronic infections and inflammatory pro- of Gastroenterology, University of Maryland School of Medicine, University of Maryland Hospital, Room N3W62, 22 South Greene cesses as cancer risk factors: possible role of nitric oxide in carcinogenesis. Mut Res 1994;305:253-264.
Wilson KT, Musselman RF, El Mahdi L, Jones RT. Immunohisto- chemical detection of inducible nitric oxide synthase in Helico- Supported by grants R01-CA67497 (to S.J.M. and K.T.W.), DK47717 (to S.J.M.) and ES07120 (to S.J.M.) from the National bacter pylori gastritis (abstr). Gastroenterology 1995;108:A942.
Albina JE, Cui S, Mateo RB, Reichner JS. Nitric oxide-mediated Institutes of Health; grant 9307-0502 from NASA (to S.J.M); grant EDT-37B from the American Cancer Society (to S.J.M.), the Medical apoptosis in murine peritoneal macrophages. J Immunol 1993; 150:5080-5085. Research Office, Department of Veterans Affairs (to S.J.M); and a Special Research Initiative Support grant from the University of Mary- 41.
De Groote MA, Granger D, Xu Y, Campbell G, Prince R, Fang FC. Genetic and redox determinants of nitric oxide cytotoxicity in a land School of Medicine (to K.T.W). Dr. Wilson is a recipient of a Career Development Award from the Crohn's and Colitis Foundation Salmonella typhimurium model. Proc Natl Acad Sci USA 1995; 92:6399-6403. of America. Presented at 1995 annual meeting of the American Gastroentero- 42.
Radi R, Beckman JS, Bush KM, Freeman BA. Peroxynitrite oxida- tion of sulfhydryls. The cytotoxic potential of superoxide and nitric logical association in San Diego, California. The authors thank Dr. Donald Hochstein at the Food and Drug oxide. J Biol Chem 1991;266:4244-4250.

Sorted by citations

Items 101–187 of 187

(10Z)-Debromohymenialdisine from Marine Sponge Stylissa sp. Regulates Intestinal Inflammatory Responses in Co-Culture Model of Epithelial Caco-2 Cells and THP-1 Macrophage Cells
Lee, S. M., Kim, N.-H., Lee, S., Kim, N.-H., Heo, J., Rho, J., & Jeong, E. J. (2019) · Molecules · doi:10.3390/molecules24183394 · Cited by 24
“It is well-known that LPS-induced NO overproduction in macrophages is catalyzed by iNOS during the inflammation process [22].”
Background
Loss of E-cadherin expression in gastric intestinal metaplasia and later stage p53 altered expression in gastric carcinogenesis
Ma, M., Devereux, T. R., Stockton, P., Sun, K.-L., Sills, R. C., Clayton, N. P., Portier, M., & Flake, G. P. (2001) · Experimental and Toxicologic Pathology · doi:10.1078/0940-2993-00190 · Cited by 24
Licocoumarone isolated from Glycyrrhiza uralensis selectively alters LPS-induced inflammatory responses in RAW 264.7 macrophages
Wu, L., Fan, Y., Fan, C., Yu, Y., Sun, L., Jin, Y., Zhang, Y., & Ye, R. D. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.02.049 · Cited by 23
Is Helicobacter pylori status relevant in the management of GORD?
Vigneri, S., Termini, R., Savarino, V., & Pace, F. (2000) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2000.00398.x · Cited by 23
Decoding inflammatory mediators in the Correa's cascade: From chronic gastritis to carcinogenesis and targeted therapies
Zhou, J., Li, J., Chen, J., Lan, X., Ai, Y., Liu, P., Peng, J., Pan, X., Zhang, Y., Zhang, H., et al. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115191 · Cited by 22
Notch Signaling Ligand Jagged1 Enhances Macrophage-Mediated Response to Helicobacter pylori
Wen, J., Chen, C., Luo, M., Liu, X., Guo, J., Wei, T., Gu, X., Gu, S., Ning, Y., & Li, Y. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.692832 · Cited by 22
Influence of Helicobacter pylori oncoprotein CagA in gastric cancer: A critical-reflective analysis
de Melo, F. F., Marques, H. S., Pinheiro, S. L. R., Lemos, F. F. B., Luz, M. S., Teixeira, K. N., Souza, C. L., & Oliveira, M. V. (2022) · World Journal of Clinical Oncology · doi:10.5306/wjco.v13.i11.866 · Cited by 22
Combating drug-resistant helicobacter pylori infection with zinc peroxide-based nanoparticles: A ROS reservoir via photochemical reaction
Wong, K. I., Wang, S., Li, M., Zhao, G., Wang, C., Wu, L., Fan, H., Yao, M., & Lu, M. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.149287 · Cited by 22
Cationic Amino Acid Transporter 2 Enhances Innate Immunity during Helicobacter pylori Infection
Barry, D. P., Asim, M., Scull, B., Piazuelo, M. B., de Sablet, T., Lewis, N. D., Coburn, L. A., Singh, K., Ellies, L. G., Gobert, A. P., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029046 · Cited by 22
“pylori SS1 [15] was maintained by passage on plates of tryptic soy agar containing 5% sheep blood, as described [16].”
Method
Helicobacter pylori Secreted Protein HP1286 Triggers Apoptosis in Macrophages via TNF-Independent and ERK MAPK-Dependent Pathways
Tavares, R., & Pathak, S. K. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00058 · Cited by 22
“Even though most of the infections are asymptomatic, long-term colonization can lead to chronic gastritis and the development of ulcers, adenocarcinoma and mucosa-associated lymphoid tissue (MALT) lymphoma (Wroblewski et al., 2010).”
Background
Nitric oxide donors retard wound healing in cultured rabbit gastric epithelial cell monolayers
Kiviluoto, T. A., Watanabe, S., Hirose, M., Sato, N., Mustonen, H. K., Puolakkainen, P. A., Rönty, M. J., Ranta-Knuuttila, T., & Kivilaakso, E. O. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.5.g1151 · Cited by 22
Investigation of Helicobacter pylori in tonsillary tissue with Pronto Dry® test and pathologic examination
Aslan, S., Yılmaz, İ., Bal, N., Şener, M., Butros, R., Demirhan, B., & Özlüoğlu, L. N. (2006) · Auris Nasus Larynx · doi:10.1016/j.anl.2006.10.004 · Cited by 21
“We concluded that the positive Pronto Dry test result of core tonsillary tissue was due to stable products of inflammatory cells infected with HP that penetrated the lamina propria [8] and reached the core region.”
Background
Role of Virulence Factors and Host Cell Signaling in the Recognition of Helicobacter Pylori and The Generation of Immune Responses
Allison, C. C., & Ferrero, R. L. (2010) · Future Microbiology · doi:10.2217/fmb.10.84 · Cited by 21
“pylori infection [262], and this enzyme converts arginine into NO.”
Background
Synthesis and characterization of a specific peptide nucleic acid that inhibits expression of inducible NO synthase
Giovine, M., Gasparini, A., Scarfı̀, S., Damonte, G., Sturla, L., Millo, E., Tonetti, M., & Benatti, U. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00302-0 · Cited by 21
Helicobacter pylori attenuates lipopolysaccharide-induced nitric oxide production by murine macrophages
Lu, D., Tang, C.-H., Chang, C.-H., Maa, M., Fang, S., Hsu, Y., Lin, Y.-H., Lin, C., Lee, W.-C., Lin, H., et al. (2011) · Innate Immunity · doi:10.1177/1753425911413164 · Cited by 19
“pylori can stimulate iNOS expression and activity in murine macrophages.(5) The release of NO appears to be stimulated by H.”
Background
Deacetylphylloketal, a New Phylloketal Derivative from a Marine Sponge, Genus Phyllospongia, with Potent Anti-Inflammatory Activity in In Vitro Co-Culture Model of Intestine
Lee, S. M., Kim, N.-H., Lee, S.-B., Kim, N.-H., Heo, J., Jeong, E. J., & Rho, J. (2019) · Marine Drugs · doi:10.3390/md17110634 · Cited by 19
“In inflammation process, the overexpressed iNOS and COX-2 triggers the production of NO and PGE2 in the activated macrophages [21,22].”
Background
Oxidative Damage of the Gastric Mucosa in Helicobacter pylori Positive Chronic Atrophic and Nonatrophic Gastritis, Before and After Eradication
Iacopini, F., Consolazio, A., Bosco, D., Marcheggiano, A., Bella, A., Pica, R., Paoluzi, O. A., Crispino, P., Rivera, M., Mottolese, M., et al. (2003) · Helicobacter · doi:10.1046/j.1523-5378.2003.00172.x · Cited by 19
Nitric oxide, inducible nitric oxide synthase and inflammation in veterinary medicine
Hunter, R. P. (2002) · Animal Health Research Reviews · doi:10.1079/ahrr200246 · Cited by 19
“iNOS mRNA and associated nitric oxide production (Tsuji et al., 1996; Wilson et al., 1996; Hahm et al., 1997).”
Background
Cellular dissociation of NF-κB and inducible nitric oxide synthase in Helicobacter pylori infection
Zhang, X., Ruiz, B., Correa, P., & Miller, M. J. S. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00375-0 · Cited by 18
Helicobacter pylori infection: pathogenesis
Panchal, P. C., Forman, J., Blumberg, D. R., & Wilson, K. T. (2003) · Current Opinion in Gastroenterology · doi:10.1097/00001574-200301000-00002 · Cited by 17
Interferon-gamma cooperates with Helicobacter pylori to induce iNOS-related apoptosis in AGS gastric adenocarcinoma cells
Perfetto, B., Buommino, E., Canozo, N., Paoletti, I., Corrado, F., Greco, R., & Donnarumma, G. (2004) · Research in Microbiology · doi:10.1016/j.resmic.2004.01.007 · Cited by 17
Nitric oxide regulates the release of somatostatin from cultured gastric rabbit primary D-cells
Arebi, N., Healey, Z. V., Bliss, P. W., Ghatei, M. A., Noorden, S. V., Playford, R. J., & Calam, J. (2002) · Gastroenterology · doi:10.1053/gast.2002.34749 · Cited by 17
Three-phase partitioning technique for the green separation of crude polysaccharides from Schizophyllum commune and its effect on macrophage activation
Tabtimmai, L., Jongruksavongkul, C., Wisetsai, A., Sonklin, C., Aiamsung, M., Chamsodsai, P., Choowongkomon, K., & Sedtananun, S. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.103735 · Cited by 16
Intact long-type DupA protein in Helicobacter pylori is an ATPase involved in multifunctional biological activities
Wang, M., Chen, C., Shao, C., Wang, S., Wang, A.-C., Yang, Y., Yuan, X., & Shao, S. (2015) · Microbial Pathogenesis · doi:10.1016/j.micpath.2015.03.002 · Cited by 16
Anti‐inflammatory and tissue‐protectant drug effects: results from a randomized placebo‐controlled trial of gastritis patients at high risk for gastric cancer
Fischbach, L. A., Corréa, P., Ramírez, H. A. C., Realpe, J. L., Collazos, T., Ruiz, B. A., Bravo, L. E., Bravo, J. C., Casabon, A. L., & Schmidt, B. (2001) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2001.00998.x · Cited by 16
Isoquinolinequinone Derivatives from a Marine Sponge (Haliclona sp.) Regulate Inflammation in In Vitro System of Intestine
Kim, N.-H., Ji, Y. K., Kim, N.-H., Tú, N. V., Rho, J., & Jeong, E. J. (2021) · Marine Drugs · doi:10.3390/md19020090 · Cited by 15
“Overexpressed iNOS and COX-2 triggers the production of NO and PGE2 in activated macrophages, leading to inflammatory processes [21,22].”
Background
High-sulforaphane broccoli sprout powder reduces serum nitric oxide metabolites in Helicobacter pylori infected patients
Mirmiran, P., Bahadoran, Z., Ghasemi, A., Jeddi, S., & Azizi, F. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.05.025 · Cited by 15
The immunoregulatory role of helper T cells in Helicobacter pylori infection
Wu, X., Gou, G., Wen, M., Wang, F., Liu, Y., Li, L., Xu, J., & Xie, R. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1593727 · Cited by 16
Helicobacter pylori Infection Increases Serum Nitrate and Nitrite More Prominently Than Serum Pepsinogens
Kodama, K., Sumii, K., Kawano, M., Kido, T., Nojima, K., Sumii, M., Haruma, K., Yoshihara, M., & Chayama, K. (2002) · Helicobacter · doi:10.1046/j.1523-5378.2002.00050.x · Cited by 14
Exogenous nitric oxide inhibits apoptosis in guinea pig gastric mucous cells
Potter, C. L., & Hanson, P. J. (2000) · Gut · doi:10.1136/gut.46.2.156 · Cited by 14
“cause the expression of the inducible form of nitric oxide (NO) synthase (iNOS) in a macrophage cell line”
Background
Interplay between Helicobacter pylori and the immune system. Clinical implications.
Szczepanik, M. (2006) · PubMed · Cited by 13
Does intragastric nitrite concentration reflect gastric carcinogenesis in Japanese Helicobacter pylori-infected patients?
Tari, A., Kodama, K., Sumii, M., Tani, H., Sumii, K., & Chayama, K. (2003) · Digestive Diseases and Sciences · doi:10.1023/a:1025438827070 · Cited by 13
“In addition, this NO release seems to be sustained; 100-fold increases in iNOS activity have been observed 24 hr after exposure of macrophages to H. pylori ( 25 ).”
Background
Role of virulence factors, cell components and adhesion in Helicobacter pylori-mediated iNOS induction in murine macrophages
Assmann, I., Enders, G. A., Puls, J., Rieder, G., Haas, R., & Hatz, R. A. (2001) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2001.tb01561.x · Cited by 13
“Our result is supported by other investigators who did not ¢nd di¡erences in iNOS induction using either epithelial cells [18] or murine macrophages [19] when cagA-positive and -negative strains were compared in stimulation assays.”
BackgroundResult
Quercetin ameliorates Helicobacter pylori ‐induced gastric epithelial cell injury by regulating specificity protein 1/lipocalin 2 axis in gastritis
Wang, Z., Zhou, X., Hu, X., & Zheng, C. (2023) · Journal of Applied Toxicology · doi:10.1002/jat.4566 · Cited by 13
“During HP infection, macrophages show an M1-like phenotype and express chemokines and inflammatory cytokines to recruit and activate other innate cells and the robust adaptive T cell response (Gan et al., 2017; Latour et al., 2022; Wilson et al., 1996).”
Background
In-vitro antioxidative, antiinflammatory properties of Aurea helianthus leaf extract a Korean traditional medicinal plant
Kim, H., Park, C.-G., Varghese, R., Lee, J. Y., Kim, Y., & Sung, G. (2017) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2017.11.046 · Cited by 12
“Overproduction of NO in response to iNOS during the inflammation process is an principal target in drug development for inflammation disease (Wilson et al., 1996).”
Background
Nitric oxide synthetase and Helicobacter pylori in patients undergoing appendicectomy
Kell, M., Winter, D. C., Ryan, D., Lynch, M., Brew, B. J., Rajpal, P., Kirwan, W. O., & Redmond, H. P. (1999) · British journal of surgery · doi:10.1046/j.1365-2168.1999.01268.x · Cited by 12
How CD4+ T cells may eliminate extracellular gastric Helicobacter?
Aebischer, T., Lucas, B., Koesling, J., Bumann, D., & Meyer, T. F. (2000) · Journal of Biotechnology · doi:10.1016/s0168-1656(00)00301-1 · Cited by 12
Characterization of Bioactive Compounds Having Antioxidant and Anti-Inflammatory Effects of Liliaceae Family Flower Petal Extracts
Kaushik, N., Kim, J.-H., Nguyen, L. N., Kaushik, N. K., & Choi, K.-A. (2022) · Journal of Functional Biomaterials · doi:10.3390/jfb13040284 · Cited by 12
“At the time of the inflammation process, high NO generation is a prime target in drug development for inflammatory diseases [43].”
Background
DNA Hypermethylation Downregulates Telomerase Reverse Transcriptase (TERT) during H. pylori-Induced Chronic Inflammation
Bussière, F. I., Michel, V., Fernandes, J., Costa, L., Camilo, V., Nigro, G., Reuse, H. D., Fiette, L., & Touati, E. (2019) · Journal of Oncology · doi:10.1155/2019/5415761 · Cited by 11
“Bacteria lysates were obtained by passage of bacterial suspensions through a French pressure cell as previously described [30].”
Method
Cloning of Mongolian gerbil cDNAs encoding inflammatory proteins, and their expression in glandular stomach during H. pylori infection
Matsubara, S., Shibata, H., Takahashi, M., Ishikawa, F., Yokokura, T., Sügimura, T., & Wakabayashi, K. (2004) · Cancer Science · doi:10.1111/j.1349-7006.2004.tb02184.x · Cited by 11
Effect of Rebamipide in Treatment of Helicobacter pylori-Associated Duodenal Ulcer: Attenuation of Chemokine Expression and Nitrosative Damage
Choi, K. W., Lee, Y. C., Chung, I. S., Lee, J. J., Chung, M. H., Kim, N., Kim, S. W., Kim, J.-G., Roe, I. H., Lee, S., et al. (2002) · Digestive Diseases and Sciences · doi:10.1023/a:1013753602149 · Cited by 11
“pylori-infected gastric mucosa after the eradication has been reported by others (6, 31).”
Background
Is apoptosis in antral mucosa correlated with serum nitrite concentration in Japanese Helicobacter pylori‐infected patients?
Tari, A., Kodama, K., Kitadai, Y., OHTA, M., Sumii, K., & Kajiyama, G. (2003) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2003.03013.x · Cited by 11
Does Serum Nitrite Concentration Reflect Gastric Carcinogenesis in Japanese Helicobacter pylori-Infected Patients?
Tari, A., Kodama, K., Kurihara, K., Fujihara, M., Sumii, K., & Kajiyama, G. (2002) · Digestive Diseases and Sciences · doi:10.1023/a:1013271605493 · Cited by 10
No Additive Effect Between Helicobacter pylori Infection and Portal Hypertensive Gastropathy on Inducible Nitric Oxide Synthase Expression in Gastric Mucosa of Cirrhotic Patients
Arafa, U. A., Fujiwara, Y., Higuchi, K., Shiba, M., Uchida, T., Watanabe, T., Tominaga, K., Oshitani, N., Matsumoto, T., & Arakawa, T. (2003) · Digestive Diseases and Sciences · doi:10.1023/a:1021707103590 · Cited by 9
“Wilson et al ( 14 ) reported that H. pylori had stimulated iNOS mRNA and enzyme activity in a murine macrophage cell line by both lipopolysaccharide-dependent and independent pathways.”
BackgroundInfluential
Epithelial cell turnover and apoptosis
Moss, S. F. (1998) · Springer eBooks · doi:10.1007/978-94-011-4882-5_14 · Cited by 9
Chloroquine inhibited Helicobacter pylori-related gastric carcinogenesis by YAP–β-catenin–autophagy axis
Li, B., Du, Y., He, J., Lv, X., Liu, S., Zhang, X., & Zhang, Y. (2023) · Microbial Pathogenesis · doi:10.1016/j.micpath.2023.106388 · Cited by 8
Exploring the physiological link of breath N 2 O through nitrification and denitrification processes in human gastric juice
Pal, M., Maithani, S., Maity, A., Chaudhuri, S., & Pradhan, M. (2018) · Journal of Breath Research · doi:10.1088/1752-7163/aae4e7 · Cited by 8
A novel polysaccharide from plant fermentation extracts and its immunomodulatory activity in macrophage RAW264.7 cells
Yan, L., Liu, C., Yan, S., Pu, W., Wu, B., Jiang, C., Li, X., Liu, Y., & Li, X. (2021) · Food and Agricultural Immunology · doi:10.1080/09540105.2021.1874884 · Cited by 8
“It was reported that induced NO synthase (iNOS), involved in immune response, could generate NO as an immune defense mechanism (Wilson et al., 1996).”
Background
Mechanisms of Helicobacter pylori -Induced Gastric Inflammation
Israel, D. A., & Peek, R. M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809954-4.00063-3 · Cited by 9
Gastric Ulcer's Diseases Pathogenesis, Complications And Strategies For Prevention
Tuorkey, M. J., & Abdul-Aziz, K. K. (2011) · Cited by 8
Sulglycotide ameliorates inflammation in lipopolysaccharide-stimulated mouse macrophage cells by blocking the NF-κB signaling pathway
Park, E. Y., Lee, H., Park, Y.-J., & Yang, J. W. (2019) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2019.1628044 · Cited by 7
“Macrophages in gastric mucosal inflammation are activated by bacterial products such as LPS and serve as a major source of inflammatory mediators in the inflammatory response [16].”
Background
Methods to Evaluate Alterations in Polyamine Metabolism Caused by Helicobacter pylori Infection
Gobert, A. P., Chaturvedi, R., & Wilson, K. T. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-034-8_26 · Cited by 7
“In addition to live bacteria directly cocultured with the macrophages, the reader is referred to other studies documenting methods for coculture of H. pylori separated from macrophages by Transwell filter supports (5), and other preparations of H. pylori that can be used, including lysates prepared in a French Pressur…”
Background
Nitric oxide in Helicobacter pylori‐induced apoptosis and its significance in gastric carcinogenesis
Xia, H. H., & Yu, W. B. C. (2003) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2003.03147.x · Cited by 7
Anti-Helicobacter pylori and Anti-inflammatory Properties of Eugenia uniflora L.
Monteiro, J. R. B., Ardisson, J. S., Athaydes, B. R., Gonçalves, R. D. C. R., Rodrigues, R. P., Kuster, R. M., & Kitagawa, R. R. (2019) · Brazilian Archives of Biology and Technology · doi:10.1590/1678-4324-2019180285 · Cited by 6
“pylori, could be related to the development of gastric cancer [1,57].”
Background
Pathogenesis of Helicobacter pylori infection
Wilson, K. T., & Fantry, G. T. (1999) · Current Opinion in Gastroenterology · doi:10.1097/00001574-199901000-00012 · Cited by 5
Effects of plant-based Korean food extracts on lipopolysaccharide-stimulated production of inflammatory mediatorsin vitro
Lee, S. Y., Kim, Y. S., Lim, J. Y., Chang, N., Kang, M.-H., Oh, S.-Y., Lee, H.-J., Kim, H., & Kim, Y. (2014) · Nutrition Research and Practice · doi:10.4162/nrp.2014.8.3.249 · Cited by 4
“responsible for the overproduction of NO during the inflammatory process [31].”
Background
Physiopathologie de la maladie ulcéreuse gastroduodénale à l'ère d'« Helicobacter pylori »
Bouarioua, N., Merrouche, M., Pospai, D., & Mignon, M. (2007) · EMC - Gastro-entérologie · doi:10.1016/s1155-1968(07)46465-3 · Cited by 4
Stimulated Murine Macrophages as a Bioassay forH. pylori-related Inhibition of Nitric Oxide Production
von Bothmer, C., Bölin, I., Pettersson, A., & Fändriks, L. (2003) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520310000816 · Cited by 4
Helicobacter pylori in Childhood
Hussey, S., & Jones, N. L. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4377-0774-8.10028-4 · Cited by 4
Nitrogen oxides and the gastric precancerous process
Miller, M. J. S., & Corréa, P. (1998) · Springer eBooks · doi:10.1007/978-94-011-4882-5_33 · Cited by 4
Can a diet rich in Brassicaceae help control Helicobacter pylori infection? A systematic review
Properzi, S., Stracci, F., Rosi, M., Lupi, C., Villarini, A., & Gili, A. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1454902 · Cited by 3
Selective inhibition of inducible cyclo-oxygenase-2 expression by antisense peptide nucleic acids in intact murine macrophages
Scarfı̀, S., Giovine, M., Pintus, R., Millo, E., Clavarino, E., Pozzolini, M., Sturla, L., Stock, R. P., Benatti, U., & Damonte, G. (2003) · Biotechnology and Applied Biochemistry · doi:10.1042/ba20030006 · Cited by 3
Mechanisms of Helicobacter pylori-induced Gastric Inflammation
Israel, D. A., & Peek, R. M. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-382026-6.00076-2 · Cited by 3
Re: Richter et al. : Possibly Protective Properties of Helicobacter pylori in Connection With GERD
Vieth, M. W., & Stolte, M. (1999) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.03068.x · Cited by 2
Molecular pathogenesis of gastric ulcers and strategies for prevention
Tuorkey, M. J., & Abdul-Aziz, K. K. (2012) · Cited by 1
Helicobacter pylori in Childhood
Crowley, E., & Hussey, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-67293-1.00027-x · Cited by 1
Mechanisms for Establishing Persistence: Immune Modulation
Samandari, T., Levine, M. M., & Sztein, M. B. (2014) · ASM Press eBooks · doi:10.1128/9781555818104.ch4 · Cited by 1
Helicobacter pylori-associated gastric cancer: is population-based screening and therapy realistic?
Tytgat, G. N. J. (1998) · Springer eBooks · doi:10.1007/978-94-011-4882-5_34 · Cited by 1
Urease de Helicobacter pylori : ativação de plaquetas e neutrófilos
Uberti, A. F. (2010) · Americanae (AECID Library) · Cited by 1
Interaction of Helicobacter pylori with the gastric mucosa
Merrell, D. S. (2006) · Cambridge University Press eBooks · doi:10.1017/cbo9780511541537.012
Modulators of Inducible Nitric Oxide Synthase: Potential Drugs for the Therapy of Gut Inflammation?
Whittle, B. J. R., Cavicchi, M., & Lamarque, D. (2002) · KARGER eBooks · doi:10.1159/000060959
Role of urease in pH modulation and virulence of Fusarium oxysporum
Schäfer, K. (2014) · Universidad de Córdoba Insitutional Repository (Universidad de Córdoba)
Caracterización molecular de cepas de "Helicobacter pylori". Reproducción del modelo animal en ratones y estudio de los mecanismos de la inflamación.
Martínez, J. G. (2001) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
Förekomst av Helicobacter spp. hos hund
Larnefeldt, L. (2006)
Gastric Carcinogenesis and H. pylori Infection
Yabana, T., Kobayashi, T., & Sugiyama, T. (1997) · Digestive Endoscopy · doi:10.1111/j.1443-1661.1997.tb00498.x
Effect of Helicobacter pylori on DNA synthesis of human epithelial cells
Toyoda, A., Hasegawa, M., Toyoda, A., Osaki, T., Hanawa, T., Taguchi, H., Kamiya, S., & Yamaguchi, H. (2005) · Journal of Infection and Chemotherapy · doi:10.1007/s10156-005-0378-y
Ureases de plantas e de bactérias : estudos funcionais e propriedades biológicas independentes da atividade enzimática
Wassermann, G. E. (2007) · Americanae (AECID Library)
Helicobacter infection alters the phenotype and inflammatory response of mouse intestinal muscle macrophages
Hoffman, & Sara, M. (2008) · K-State Research Exchange (Kansas State University)
Role of nitric oxide in the pathogenesis of gastrointestinal diseases.
Yanaka, A. (1999) · Ensho · doi:10.2492/jsir1981.19.129
Interação de Escherichia coli enteropatogênica (EPEC) atípica com fagócito profissional.
de Melo, K. C. M. (2016) · doi:10.11606/t.87.2016.tde-25082016-151946
A potential role of hydrogen sulfide (H2S) in the regulation of the Ras-ERK signaling-dependent transcription of DNA methyltransferases
Nikitina, T. A. (2016) · Biopolymers and Cell · doi:10.7124/bc.000937
“Pylori bacteria infection stimulation of the macrophage NOS expression induced the NO-dependent DNA methylation in gastric mucosa [54, 55].”
Background
The Effects and Mechanism of Action of Cimetidine on Inducible Nitric Oxide Synthase Using an Equine Soft-Tissue Inflammation Model.
Hunter, R. P. (2000) · doi:10.31390/gradschool_disstheses.7201
Demonstration of Helicobacter pylori (HP) and Other Related Organisms
Vaiphei, K. (2021) · Springer eBooks · doi:10.1007/978-981-16-6026-9_6
ENDOGENOUS GLUCOCORTICOID SIGNALING IS REQUIRED FOR NORMAL MACROPHAGE RESPONSE TO H. pylori INFECTION
Khadka, S. (2024) · doi:10.33915/etd.12613
Helicobacter pylori in Childhood
Egan, R., Crowley, E., & Hussey, S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-11760-2.00027-6
Life, death, and inflammation: manipulation of phagocyte function byHelicobacter pylori
Allen, L. H. (2006) · Cambridge University Press eBooks · doi:10.1017/cbo9780511541513.004
Ureases vegetais e microbianas : efeitos na exocitose e participação de eicosanóides
Olivera‐Severo, D. (2006) · Americanae (AECID Library)

Authors: Wilson, K., Ramanujam, K., Mobley, H., Musselman, R., James, S., & Meltzer, S.
Affiliations: University of Maryland, Baltimore (US)
Venue: Gastroenterology
Publisher: Elsevier BV
Published: 1996-12
Volume: 111
Issue: 6
Pages: 1524-1533
ISSN: 0016-5085 (ISSN-L)
DOI: 10.1016/s0016-5085(96)70014-8
OpenAlex: W2072178703
Cited by: 189
References: 6
Citations by year: 2025: 3 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 9 · 2019: 8 · 2018: 4 · 2017: 8 · 2016: 7 · 2015: 5 · 2014: 7 · 2013: 4 · 2012: 5
FWCI: 8.74
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01es007120-03, 5r01ca067497-03)
National Cancer Institute (R01-CA67497)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 47717, R01DK047717)
National Institute of Environmental Health Sciences (ES07120)
Topics: Health Sciences › Medicine › Gastroenterology › Helicobacter pylori-related gastroenterology studies
Health Sciences › Medicine › Pharmacology (medical) › Inflammatory mediators and NSAID effects
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: Helicobacter pylori, inducible nitric oxide synthase, nitric oxide production, macrophages, RAW 264.7 macrophages, lipopolysaccharide, polymyxin B, interferon-gamma, gastritis, gastric cancer, bacterial virulence factors, gastric mucosa colonization, nitric oxide synthase inhibition, interleukin-1
MeSH terms: Animals, Cell Line, Humans, Interferon-gamma, Macrophage Activation, Macrophages, Helicobacter pylori, Helicobacter Infections, Nitric Oxide Synthase, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Helicobacter pylori stimulates inducible nitric oxide synthase expression and activity in a murine macrophage cell line

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks