CoChat
Sign Up
Cited by 267Genetic factors in colorectal cancerColorectal Cancer Screening and DetectionHelicobacter pylori-related gastroenterology studies

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Gastrin and colorectal cancer: A prospective study

Open access
Thorburn*, Christine M., Friedman‡, Gary D., Dickinson§, Chris J., Vogelman∥, Joseph H., Orentreich∥, Norman, Parsonnet*,#, Julie·1998·Gastroenterology
DOI 10.1016/s0016-5085(98)70193-3
Open this paper in CoChat — free accountOpen PDF

Abstract

BACKGROUND & AIMS: Gastrin is a putative promoter of colorectal carcinomas. The aim of this study was to evaluate the temporal relationship between gastrinemia and development of colorectal malignancy. METHODS: We conducted a nested case-control study among 128,992 subscribers to a health maintenance program who had participated in a multiphasic health checkup between 1964 and 1969. Serum had been frozen since the checkup and the cohort followed up for cancer. Of 1881 incident colorectal carcinoma cases, 250 were randomly selected; 1 control without cancer was matched to each case by age, sex, education, and date of serum collection. Stored sera were tested for Helicobacter pylori immunoglobulin G and for gastrin and glycine-extended gastrin. RESULTS: Verified cases included 166 colon cancers, 58 rectal cancers, and 9 with cancer in both locations. A mean of 15.3 years had elapsed between serum collection and diagnosis of cancer. Median gastrin levels were similar in cases and controls (41.7 vs. 40.7 pg/mL). However, a gastrin level above normal was associated with increased risk for colorectal malignancy (odds ratio, 3.9; 95% confidence interval, 1.5-9.8). If this association is causal, 8.6% of colorectal cancers could be attributed to high serum gastrin level. CONCLUSIONS: Hypergastrinemia is associated with an increased risk of colorectal carcinoma.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/s0016-5085(98)70193-3

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Research works printed but not linked: 1

  1. McCloy, 1992, Implications of a review of long-term safety of omeprazole and management strategies for peptic disease, Hepatogastroenterology, 39, 90

Cited by

Sorted by citations

See all 267

Related

See all

Metadata

Authors
Thorburn*, C. M., Friedman‡, G. D., Dickinson§, C. J., Vogelman∥, J. H., Orentreich∥, N., & Parsonnet*, #.
Affiliations
  • Kaiser Permanente (US)
  • Stanford University (US)
Venue
Gastroenterology
Publisher
Elsevier BV
Published
1998-08
Volume
115
Issue
2
Pages
275-280
ISSN
0016-5085 (ISSN-L)
DOI
10.1016/s0016-5085(98)70193-3
OpenAlex
W2029989332
Cited by
267
References
42
Citations by year
2026: 1 · 2025: 4 · 2024: 3 · 2023: 8 · 2022: 5 · 2021: 7 · 2020: 14 · 2019: 12 · 2018: 9 · 2017: 12 · 2016: 13 · 2015: 1 · 2014: 7 · 2013: 19 · 2012: 12
FWCI
8.89
Type
journal article
Language
en
Open access
Licence
Locations
  • Gastroenterology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (1r03ca065801-01a1, DK34933)
  • National Institute of Diabetes and Digestive and Kidney Diseases (P30DK034933)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
  • Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
  • Health Sciences › Medicine › Gastroenterology › Helicobacter pylori-related gastroenterology studies
Keywords
gastrin, hypergastrinemia, colorectal cancer, colon cancer, rectal cancer, serum gastrin, cancer risk, Helicobacter pylori, glycine-extended gastrin, temporal relations
MeSH terms
Colonic Neoplasms, Female, Gastrins, Humans, Male, Middle Aged, Prospective Studies, Rectal Neoplasms, Risk Factors, Colorectal Neoplasms, Cohort Studies, Incidence, Multivariate Analysis, Odds Ratio, Case-Control Studies

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review