Familial risk among Japanese patients with endometriosis
Abstract
Objectives This study was designed to examine the prevalence of endometriosis among female siblings of patients with endometriosis in Japan. Methods A total of 339 patients with endometriosis were questioned about endometriosis in their sisters. The control group consisted of 284 Japanese healthy fertile women with no history of endometriosis. Similarly, the controls were interviewed about their sisters. Results We detected sisters with endometriosis in 8.8% of cases and 1.5% of the control population. The relative risk of endometriosis in female siblings was 5.7. However, a significant difference was not seen in age at diagnosis and clinical stage between patients with or without a family history of endometriosis. Conclusions These data demonstrate a familial tendency for endometriosis and suggest that endometriosis has a genetic factor in the pathogenesis.
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The self-reported family history rate in this sample (40%) is higher than rates reported in studies from Puerto Rico (20%), Brazil (8.9%), Japan (8.8%), and the US (8.1%).
“This rate of family history is higher than what has been reported in other published studies of patients from Puerto Rico (20%) (31), Brazil (8.9%) (32), Japan (8.8%) (33), and the US (8.1%) (34).”
From Patients’ report on how endometriosis affects health, work, and daily life (2010) · cites this paper as [33]
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References 18 · Cited by 48
- Authors
- Kashima, K., Ishimaru, T., Okamura, H., Suginami, H., Ikuma, K., Murakami, T., Iwashita, M., & Tanaka, K.
- Affiliations
- Niigata University (JP)
- Nagasaki University (JP)
- Kumamoto University (JP)
- Kyoto Medical Center (JP)
- Takarazuka City Hospital (JP)
- Tohoku University (JP)
- Kyorin University (JP)
- Corresponding author
- Kashima, K.
- Venue
- International Journal of Gynecology & Obstetrics
- Publisher
- Wiley
- Published
- 2003-10-30
- Volume
- 84
- Issue
- 1
- Pages
- 61-64
- ISSN
- 0020-6695 (ISSN-L)
- 0020-7292
- OpenAlex
- W2003635697
- Cited by
- 48
- References
- 18
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 4 · 2019: 4 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 6 · 2012: 1
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Gynecology & Obstetrics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Keywords
- endometriosis, familial risk, sisters, family history (medicine), genetic susceptibility, prevalence, age at diagnosis, clinical stage, Japanese women
- MeSH terms
- Adolescent, Adult, Endometriosis, Female, Humans, Japan, Middle Aged, Surveys and Questionnaires, Risk Factors, Prevalence, Case-Control Studies, Genetic Predisposition to Disease, Siblings
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