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A rapid method for detecting and mapping homology between heterologous DNAs. Evaluation of polyomavirus genomes.
Open accessAbstract
A new approach for evaluating homologous sequences among related DNAs is presented. Conventional filter hybridization techniques are employed at 35 degrees C in a range of formamide concentrations in order to perform annealings at effective temperatures as low as Tm -50 degrees C which permits the detection of regions of homology with as much as 33% base mismatch. Under such nonstringent conditions, high levels of specific annealing can be obtained at plateau levels. In combination with the Southern "blotting" technique (1975), this approach can be used to perform biochemical heteroduplex melting experiments. The homology among the genomes of the murine polyoma virus (Py), the simian virus 40 (SV40), and the human papovavirus BK was evaluated using this new methodology.
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Ellis, R. W., DeFeo, D., Shih, T. Y., Gonda, M. A., Young, H. A., Tsuchida, N., Lowy, D. R., & Scolnick, E. M. (1981) · Nature · doi:10.1038/292506a0 · Cited by 721
Legouis, R., Hardelin, J.-P., Levilliers, J., Claverie, J.-M., Compain, S., Wunderle, V., Millasseau, P., Le Paslier, D., Cohen, D., & Caterina, D. (1991) · Cell · doi:10.1016/0092-8674(91)90193-3 · Cited by 678
Global analysis of repetitive DNA from unassembled sequence reads using RepeatExplorer2
Novák, P., Neumann, P., & Macas, J. (2020) · Nature Protocols · doi:10.1038/s41596-020-0400-y · Cited by 281
Dynamic allele-specific hybridization
Howell, W. M., Jobs, M., Gyllensten, U., & Brookes, A. J. (1999) · Nature Biotechnology · doi:10.1038/5270 · Cited by 278
Mode of Action of the Tetracyclines and the Nature of Bacterial Resistance to Them
Chopra, I. (1985) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-70304-1_6 · Cited by 44
Metadata
- Authors
- Howley, P. M., Israel, M. A., Law, M. F., & Martin, M. A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1979-06
- Volume
- 254
- Issue
- 11
- Pages
- 4876-4883
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1613179247
- Cited by
- 337
- References
- 0
- FWCI
- 12.04
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Howley, P. M., Israel, M. A., Law, M. F., & Martin, M. A. (1979). A rapid method for detecting and mapping homology between heterologous DNAs. Evaluation of polyomavirus genomes. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(17)30093-5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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