The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Phospholipids as ionophores.
Open accessAbstract
The ionophoretic capabilities of phospholipids have been examined by direct measurement in a Pressman cell of the phospholipid-mediated translocation of cations across an organic phase separating two aqueous phases. Cardiolipin and phosphatidic acid were the most active inonophores among the phospholipids tested, with activities comparable to that of X537A in respect to the translocation of divalent cations. Cardiolipin translocates both divalent and monovalent cations at approximately equal rates. The ionophoretic activity of cardiolipin could be modulated by other phospholipids (inhibition), by butacaine (stimulation), by complexation with cytochrome c (inhibition), and by ruthenium red and lanthanum (inhibition). The rate of translocation of cations mediated by cardiolipin was independent of pH over a wide pH range (5.4 to 8.3). The same general pattern of properties observed for cardiolipin applied to phosphatidic acid except for stimulation by butacaine. Complexation of phospholipid mixtures, such as asolectin or mitochondrial lipid, with reduced cytochrome c, enhanced the ionophoretic capability of these phospholipids by 1 order of magnitude. The complex thus formed has the properties of a polyionophore. The possible physiological significance of this enormous ionophoretic potential of phospholipids is examined.
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Cites
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Cited by
A model for receptor-regulated calcium entry
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Is phosphatidic acid a calcium ionophore under neurohumoral control?
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Role of calcium in the hormonal regulation of liver metabolism
Williamson, J. R., Cooper, R. H., & Hoek, J. B. (1981) · Biochimica et Biophysica Acta (BBA) - Reviews on Bioenergetics · doi:10.1016/0304-4173(81)90012-4 · Cited by 317
Metadata
- Authors
- Tyson, C. A., Vande Zande, H., & Green, D. E.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1976-03
- Volume
- 251
- Issue
- 5
- Pages
- 1326-1332
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1582697238
- Cited by
- 271
- References
- 17
- FWCI
- 7.42
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
