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Isolation of a collagen-binding fragment from fibronectin and cold-insoluble globulin.
Open accessAbstract
Limited proteolytic cleavage of fibronectin and plasma cold-insoluble globulin with cathepsin D produced two major fragments. The smaller, Mr = 72,000 fragment bound to collagen and contained most of the cysteine in the molecule. This region contains intrachain disulfide bonds which maintain a conformation that is necessary for interaction with collagen. Cleavage of the intact protein and the 72,000-dalton fragment with plasmin localized the collagen-binding region in cold-insoluble globulin to a sequence of about 42,000 daltons. This region is located approximately two-thirds of the linear distance from the NH2 terminus of each chain in the dimeric molecule.
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Citations
Cited by
Ignotz, R. A., & Massagué, J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35666-1 · Cited by 2,492
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Terranova, V. P., Rao, C. N., Kalebic, T., Margulies, I. M., & Liotta, L. A. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.2.444 · Cited by 414
Partial primary structure of bovine plasma fibronectin: Three types of internal homology
Petersen, T. E., Thøgersen, H. C., Skorstengaard, K., Vibe-Pedersen, K., Sahl, P., Sottrup-Jensen, L., & Magnusson, S. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.1.137 · Cited by 398
Metadata
- Authors
- Balian, G., Click, E. M., Crouch, E., Davidson, J. M., & Bornstein, P.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1979-03
- Volume
- 254
- Issue
- 5
- Pages
- 1429-1432
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1560078646
- Cited by
- 205
- References
- 0
- FWCI
- 18.74
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Balian, G., Click, E. M., Crouch, E., Davidson, J. M., & Bornstein, P. (1979). Isolation of a collagen-binding fragment from fibronectin and cold-insoluble globulin. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(17)37782-7
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.