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Sodium bicarbonate in seminal plasma stimulates the motility of mammalian spermatozoa through direct activation of adenylate cyclase.
Open accessAbstract
Recently, a low molecular weight factor, which specifically stimulates sperm adenylate cyclase, was found in porcine seminal plasma (Okamura, N., and Sugita, Y. (1983) J. Biol. Chem. 258, 13056-13062). The purified factor was analyzed by 1H NMR, 13C NMR, infrared spectroscopy, and elementary analysis and identified as sodium bicarbonate. The effects of sodium bicarbonate both on adenylate cyclase activity in porcine spermatozoa and on sperm motility have been studied. Sperm adenylate cyclase was found to be specifically activated by bicarbonate over the physiological concentration range. In contrast, the adenylate cyclase activity in other tissues was not affected. The same concentration range of bicarbonate which resulted in activation of adenylate cyclase also stimulated sperm motility. The motility and enzyme activity of spermatozoa in all species so far tested (human, bovine, rat, mouse, and dog) were found to be similarly sensitive to bicarbonate concentration. These results show that the bicarbonate-sensitive adenylate cyclase system regulates sperm motility and suggest that this system is common to all mammals.
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Cited by
Flesch, F. M., Brouwers, J. F. H. M., Nievelstein, P. F. E. M., Verkleij, A. J., van Golde, L. M. G., Colenbrander, B., & Gadella, B. M. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.19.3543 · Cited by 296
Soluble adenylyl cyclase in health and disease
Schmid, A., Meili, D., & Salathe, M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.07.010 · Cited by 39
“Its role was initially thought to be confined to fertility and capacitation [50,51], supported by the finding that sAC knockout mice were viable but infertile [25].”
Metadata
- Authors
- Okamura, N., Tajima, Y., Soejima, A., Masuda, H., & Sugita, Y.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1985-08
- Volume
- 260
- Issue
- 17
- Pages
- 9699-9705
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1570735806
- Cited by
- 394
- References
- 0
- FWCI
- 5.76
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Sodium bicarbonate in seminal plasma stimulates the motility of mammalian spermatozoa through direct activation of adenylate cyclase. https://app.cochat.ai/papers/10.1016/s0021-9258(17)39295-5
- The paper
- Okamura, N., Tajima, Y., Soejima, A., Masuda, H., & Sugita, Y. (1985). Sodium bicarbonate in seminal plasma stimulates the motility of mammalian spermatozoa through direct activation of adenylate cyclase. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(17)39295-5
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