The DOI matches its Crossref record.
Gamma-carboxyglutamate in a neuroactive toxin.
Open accessAbstract
The venom of a fish-hunting cone snail (Conus geographus) contains a novel toxin, the "sleeper" peptide, which induces a sleep-like state in mice when injected intracerebrally. We demonstrate that this peptide contains 5 mol of gamma-carboxyglutamate (Gla) in 17 amino acids. The amino acid sequence of the sleeper peptide is Gly-Glu-Gla-Gla-Leu-Gln-Gla-Asn-Gln-Gla-Leu-Ile-Arg-Gla-Lys-Ser-Asn-NH2.
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Cited by
Faulkner, D. J. (1990) · Natural Product Reports · doi:10.1039/np9900700269 · Cited by 4,866
Blunt, J. W., Copp, B. R., Hu, W.-P., Munro, M. H. G., Northcote, P. T., & Prinsep, M. R. (2009) · Natural Product Reports · doi:10.1039/b805113p · Cited by 520
Vitamin K-Dependent Biosynthesis of γ-Carboxyglutamic Acid
Furie, B., Bouchard, B. A., & Furie, B. C. (1999) · Blood · doi:10.1182/blood.v93.6.1798.406k22_1798_1808 · Cited by 422
Discovery, Synthesis, and Structure–Activity Relationships of Conotoxins
Akondi, K. B., Muttenthaler, M., Dutertre, S., Kaas, Q., Craik, D. J., Lewis, R. J., & Alewood, P. F. (2014) · Chemical Reviews · doi:10.1021/cr400401e · Cited by 323
Chemistry and Enzymology of Disulfide Cross-Linking in Proteins
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Metadata
- Authors
- McIntosh, J. M., Olivera, B. M., Cruz, L. J., & Gray, W. R.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1984-12
- Volume
- 259
- Issue
- 23
- Pages
- 14343-14346
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1583635771
- Cited by
- 201
- References
- 0
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- McIntosh, J. M., Olivera, B. M., Cruz, L. J., & Gray, W. R. (1984). Gamma-carboxyglutamate in a neuroactive toxin. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(17)42601-9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
