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Acylation of bovine rhodopsin by [3H]palmitic acid.
Open accessAbstract
Bovine retinas or preparations of rod outer segments incorporate [3H]palmitic acid into rhodopsin. The incorporation is both time- and temperature-dependent. The major product retains the chromatographic and electrophoretic properties of rhodopsin and remains photosensitive as demonstrated by alteration of its chromatographic behavior upon exposure to light. The incorporated radioactivity resists extraction with organic solvents and is not dissociated from the protein by detergents or under the denaturing conditions of sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Radioactive free fatty acid can, however, be released by alkaline hydrolysis. Hydroxylamine treatment yields a mixture of the free fatty acid and the fatty acyl hydroxamate. These results demonstrate the formation of an ester bond between [3H]palmitic acid and rhodopsin. Cycloheximide fails to inhibit the incorporation. This finding along with the ability of rod outer segments to support the incorporation point to the acylation of rhodopsin as a late post-translational event.
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Cited by
PROTEIN PRENYLATION: GENES, ENZYMES, TARGETS, AND FUNCTIONS
Schafer, W. R., & Rine, J. (1992) · Annual Review of Genetics · doi:10.1146/annurev.ge.26.120192.001233 · Cited by 377
McBee, J. K., Palczewski, K., Baehr, W., & Pepperberg, D. R. (2001) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(01)00002-7 · Cited by 366
Role of cholesterol in the function and organization of G-protein coupled receptors
Pucadyil, T. J., & Chattopadhyay, A. (2006) · Progress in Lipid Research · doi:10.1016/j.plipres.2006.02.002 · Cited by 296
Mattoo, A. K., & Edelman, M. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.6.1497 · Cited by 273
G Protein-Coupled Receptor Rhodopsin: A Prospectus
Filipek, S., Stenkamp, R. E., Teller, D. C., & Palczewski, K. (2003) · Annual Review of Physiology · doi:10.1146/annurev.physiol.65.092101.142611 · Cited by 267
Metadata
- Authors
- O'Brien, P. J., & Zatz, M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1984-04
- Volume
- 259
- Issue
- 8
- Pages
- 5054-5057
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1556609530
- Cited by
- 199
- References
- 0
- FWCI
- 3.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- O'Brien, P. J., & Zatz, M. (1984). Acylation of bovine rhodopsin by [3H]palmitic acid. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(17)42954-1
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