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Cited by 123

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Hemin-mediated DNA strand scission.

Aft, R L, Mueller, G C·1983·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(17)44341-9
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Abstract

Hemin (ferric protoporphyrin IX chloride) has been shown to cause strand scission in DNA in a reaction which requires the presence of oxygen and the reducing agent, 2-mercaptoethanol. In model studies, circular supercoiled plasmid DNA is converted within 30 min to the open circle and linear forms. With longer incubation times the DNA is degraded to small pieces. The reaction is markedly influenced by the addition of divalent cations; Mg2+ and Ca2+ inhibit the reaction while the transition metals Co2+, Zn2+, Ni2+, and Cu2+ promote the degradation. These observations are discussed in relation to the role of hemin in the modulation of gene expression during cell differentiation.

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Research works printed but not linked: 28

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Metadata

Authors
Aft, R. L., & Mueller, G. C.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1983-10
Volume
258
Issue
19
Pages
12069-12072
ISSN
0021-9258
DOI
10.1016/s0021-9258(17)44341-9
Cited by
123
References
1
Language
en
Licence

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