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Isolation and Properties of Lens Aldose Reductase
Open accessAbstract
Exposure of the lens of the eye to a high concentration of an aldose, such as n-glucose, n-galactose, or n-xylose, results in the accumulation of the corresponding sugar alcohols. The high concentration which t.hese alcohols reach within the lens fibers appears to be responsible for t,he loss of clarity of the lens that is observed in experimental sugar cataracts (1). The reduced triphosphopyridine nucleotide-dependent reduction of aldoses to polyols by extracts of seminal vesicles and placenta has been investigated by Hers (2, 3) who named the enzyme aldose reductase. A similar enzymatic activity was first described in the lens by van Heyningen (4) and was studied in more detail by Kinoshita et al. (5). Although lens aldose reductase plays a central role in the etiology of sugar cataracts, t,he detailed properties of this enzyme have not previously been determined. It is the purpose of this report to present a method for the preparation of this enzyme and a description of its properties.
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Metadata
- Authors
- Hayman, S., & Kinoshita, J. H.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1965-02
- Volume
- 240
- Issue
- 2
- Pages
- 877-882
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1501604225
- Cited by
- 556
- References
- 0
- FWCI
- 4.48
- Type
- journal article
- Language
- en
- Open access
- hybrid
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