Cited by 889Cancer therapeutics and mechanismsBioactive Compounds and Antitumor AgentsMetal complexes synthesis and properties

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II

Open access

Tewey, K M, Chen, G L, Nelson, E M, Liu, L F·1984·Journal of Biological Chemistry

DOI 10.1016/s0021-9258(17)47282-6

Open this paper in CoChat — free account

Abstract

Many intercalative antitumor drugs have been shown to induce reversible protein-linked DNA breaks in cultured mammalian cells. Using purified mammalian DNA topoisomerase II, we have demonstrated that the antitumor drugs ellipticine and 2-methyl-9-hydroxyellipticine (2-Me-9-OH-E+) can produce reversible protein-linked DNA breaks in vitro. 2-Me-9-OH-E+ which is more cytotoxic toward L1210 cells and more active against experimental tumors than ellipticine is also more effective in stimulating DNA cleavage in vitro. Similar to the effect of 4'-(9-acridinylamino)-methanesulfon-m-anisidide (m-AMSA) on topoisomerase II in vitro, the mechanism of DNA breakage induced by ellipticines is most likely due to the drug stabilization of a cleavable complex formed between topoisomerase II and DNA. Protein denaturant treatment of the cleavable complex results in DNA breakage and covalent linking of one topoisomerase II subunit to each 5'-end of the cleaved DNA. Cleavage sites on pBR322 DNA produced by ellipticine or 2-Me-9-OH-E+ treatment mapped at the same positions. However, many of these cleavage sites are distinctly different from those produced by the antitumor drug m-AMSA which also targets at topoisomerase II. Our results thus suggest that although mammalian DNA topoisomerase II may be a common target of these antitumor drugs, drug-DNA-topoisomerase interactions for different antitumor drugs may be different.

Integrity signals

Registry

Crossref · 10.1016/s0021-9258(17)47282-6

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

DNA Topoisomerases
Gellert, M. F. (1981) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.50.070181.004311 · Cited by 990
DNA Gyrase and the Supercoiling of DNA
Cozzarelli, N. R. (1980) · Science · doi:10.1126/science.6243420 · Cited by 720
DNA Modification and Cancer
Waring, M. J. (1981) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.50.070181.001111 · Cited by 690
The Anticancer Agent Adriamycin Can Be Actively Cytotoxic Without Entering Cells
Triton, T. R., & Yee, G. K. (1982) · Science · doi:10.1126/science.7089561 · Cited by 573
Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide.
Nelson, E. M., Tewey, K. M., & Liu, L. F. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.5.1361 · Cited by 561
Self-citation
Cleavage of DNA by mammalian DNA topoisomerase II.
Liu, L. F., Rowe, T. C., Yang, L., Tewey, K. M., & Chen, G. L. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)43815-4 · Cited by 534
Self-citation
Type II DNA topoisomerases: enzymes that can unknot a topologically knotted DNA molecule via a reversible double-strand break.
Liu, L. F., Liu, C.-C., & Alberts, B. (1980) · Cell · doi:10.1016/s0092-8674(80)80046-8 · Cited by 486
Self-citation
Protein-associated deoxyribonucleic acid strand breaks in L1210 cells treated with the deoxyribonucleic acid intercalating agents 4'-(9-acridinylamino)methanesulfon-m-anisidide and adriamycin
Zwelling, L. A., Michaels, S., Erickson, L. C., Ungerleider, R. S., Nichols, M., & Kohn, K. W. (1981) · Biochemistry · doi:10.1021/bi00526a006 · Cited by 374
A homogeneous type II DNA topoisomerase from HeLa cell nuclei.
Miller, K. G., Liu, L. F., & Englund, P. T. (1981) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)52552-2 · Cited by 359
Self-citation
Terminal stages of SV40 DNA replication proceed via multiply intertwined catenated dimers
Sundin, O. H., & Varshavsky, A. J. (1980) · Cell · doi:10.1016/0092-8674(80)90118-x · Cited by 354

Show all 39 references

Research works printed but not linked: 3

Zwelling, 1982, Cancer Res., 42, 2687
Burr-Furlong, 1978, Cancer Res., 38, 1329
Pommier, 1982, Biochem. Biophys. Res. Commun., 77, 1150

Sorted by citations

Items 401–500 of 889

The Genetic Basis of Resistance to Cancer Chemotherapy
Woodhouse, J., & Ferry, D. R. (1995) · Annals of Medicine · doi:10.3109/07853899509031953 · Cited by 35
Quinone–carbohydrate nonglucoside conjugates as a new type of cytotoxic agents: Synthesis and determination of in vitro activity
Pelageev, D. N., Dyshlovoy, S. A., Pokhilo, N. D., Денисенко, В. А., Borisova, K. L., Amsberg, G. K.-V., Bokemeyer, C., Fedorov, S. N., Honecker, F. U., & Ануфриев, В. Ф. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2014.03.006 · Cited by 35
“The cytotoxic effects of these compounds are mainly exerted through inhibition of DNA topoisomerase-II [2,3] as well as formation of semiquinones and”
Background
The synthesis of benzo[h]quinolines as topoisomerase inhibitors
Kerry, M. A., Boyd, G. W., Mackay, S. P., Meth‐Cohn, O., & Platt, L. (1999) · Journal of the Chemical Society Perkin Transactions 1 · doi:10.1039/a903402a · Cited by 35
Mechanism of action and antitumor activity of (S)-10-(2,6-dimethyl-4-pyridinyl)-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyridol [1,2,3-de]-[1,4]benzothiazine-6-carboxylic acid (WIN 58161)
Coughlin, S. A., Danz, D. W., Robinson, R. G., Klingbeil, K. M., Wentland, M. P., Corbett, T. H., Waud, W. R., Zwelling, L. A., Altschuler, E. M., Bales, E. S., et al. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00016-s · Cited by 35
Alterations of spermatogenesis in etoposide-treated rats: A stereological study
Freitas, F. E. L., Cordeiro, F., Sasso‐Cerri, E., Lucas, S. R. R., & Miraglia, S. M. (2002) · Americanae (AECID Library) · Cited by 35
An Antitumor Drug-Induced Topoisomerase Cleavage Complex Blocks a Bacteriophage T4 Replication Fork In Vivo
Hong, G., & Kreuzer, K. N. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.2.594-603.2000 · Cited by 35
Change of the sequence specificity of daunorubicin-stimulated topoisomerase II DNA cleavage by epimerization of the amino group of the sugar moiety.
Capranico, G., Butelli, E., & Zunino, F. (1995) · PubMed · Cited by 35
Water Soluble Inhibitors of Topoisomerase I: Quaternary Salt Derivatives of Camptothecin
Lackey, K. E., Sternbach, D. D., Croom, D. K., Emerson, D. L., Evans, M. G., Leitner, P. L., Luzzio, M. J., McIntyre, G. D., Vuong, A., Yates, J., et al. (1996) · Journal of Medicinal Chemistry · doi:10.1021/jm950507y · Cited by 35
Topoisomerase IIβ and its role in different biological contexts
Bollimpelli, V. S., Dholaniya, P. S., & Kondapi, A. K. (2017) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2017.06.021 · Cited by 35
Inspired by Sea Urchins: Warburg Effect Mediated Selectivity of Novel Synthetic Non-Glycoside 1,4-Naphthoquinone-6S-Glucose Conjugates in Prostate Cancer
Dyshlovoy, S. A., Pelageev, D. N., Hauschild, J., Sabutskii, Y. E., Khmelevskaya, E. A., Krisp, C., Kaune, M., Venz, S., Borisova, K. L., Busenbender, T., et al. (2020) · Marine Drugs · doi:10.3390/md18050251 · Cited by 34
“The mechanism of anticancer activity of the natural 1,4-naphthoquinones and other related compounds includes generation of free superoxide radicals, which results in DNA damage and may lead to p53-independent cell death [22,47,48], as well as inhibition of topoisomerase-II [47,49,50].”
Background
Mechanisms and Regulation of DNA-Protein Crosslink Repair During DNA Replication by SPRTN Protease
Perry, M. C., & Ghosal, G. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.916697 · Cited by 34
Doxorubicin-induced DNA breaks, topoisomerase II activity and gene expression in human melanoma cells
Ramachandran, C., Samy, T. S. A., Huang, X. L., Yuan, Z. K., & Krishan, A. (1993) · Biochemical Pharmacology · doi:10.1016/0006-2952(93)90293-6 · Cited by 34
Higher Order Chromatin Structures in Maize and Arabidopsis
Paul, A., & Ferl, R. J. (1998) · The Plant Cell · doi:10.1105/tpc.10.8.1349 · Cited by 34
Late Effects of Treatment for Wilms Tumor
Green, D. M., Donckerwolcke, R. A. M. G., Evans, A. E., & D’Angio, G. J. (1995) · Hematology/Oncology Clinics of North America · doi:10.1016/s0889-8588(18)30048-0 · Cited by 32
DNase I Hypersensitivity Is Independent of Endogenous Topoisomerase II Activity During Chicken Erythrocyte Differentiation
Muller, M. T., & Mehta, V. B. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.9.3661 · Cited by 34
Overproduction of topoisomerase II in an ataxia telangiectasia fibroblast cell line: comparison with a topoisomerase II-overproducing hamster cell mutant
Davies, S. M., Harris, A. L., & Hickson, I. D. (1989) · Nucleic Acids Research · doi:10.1093/nar/17.4.1337 · Cited by 34
Integration of Simian Virus 40 into Cellular DNA Occurs at or near Topoisomerase II Cleavage Hot Spots Induced by VM-26 (Teniposide)
Bodley, A. L., Huang, H. C., Yu, C., & Liu, L. F. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.10.6190 · Cited by 34
Self-citation
Mammalian DNA repair — use of mutants hypersensitive to cytotoxic agents
Hickson, I. D., & Harris, A. L. (1988) · Trends in Genetics · doi:10.1016/0168-9525(88)90097-2 · Cited by 34
The inhibition of cellular recovery in human tumour cells by inhibitors of topoisomerase
Musk, S., & Steel, G. G. (1990) · British Journal of Cancer · doi:10.1038/bjc.1990.298 · Cited by 34
Topoisomerases: Resistance versus Sensitivity, How Far We Can Go?
Bansal, S., Bajaj, P., Pandey, S., & Tandon, V. (2016) · Medicinal Research Reviews · doi:10.1002/med.21417 · Cited by 33
A Topology-Centric View on Mitotic Chromosome Architecture
Piskadlo, E., & Oliveira, R. A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122751 · Cited by 30
Cadmium disrupts the DNA damage response by destabilizing RNF168
Zhang, S., Hao, S., Qiu, Z., Wang, Y., Zhao, Y., Li, Y., Gao, W. Y., Wu, Y., Liu, C., Xu, X., et al. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.110745 · Cited by 35
Topoisomerase II and tubulin inhibitors both induce the formation of apoptotic topoisomerase I cleavage complexes
Sordet, O., Goldman, A. R., & Pommier, Y. G. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0463 · Cited by 33
Bacteriophage T4, a model system for understanding the mechanism of type II topoisomerase inhibitors
Kreuzer, K. N. (1998) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(98)00145-6 · Cited by 33
A knotted free minicircle in kinetoplast DNA.
Ryan, K. A., Shapiro, T. A., Rauch, C. A., Griffith, J. D., & Englund, P. T. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.16.5844 · Cited by 33
Mutagenesis of L5178Y/TK+ / − −3.7.2C mouse lymphoma cells by the clastogen ellipticine
Moore, M. M., Brock, K. H., Doerr, C. L., & DeMarini, D. M. (1987) · Environmental Mutagenesis · doi:10.1002/em.2860090206 · Cited by 33
Molecular analysis of mutations induced by the intercalating agent ellipticine at the hisd3052 allele of salmonella typhimurium TA98
DeMarini, D. M., Abu‐Shakra, A., Gupta, R., Hendee, L. J., & Levine, J. G. (1992) · Environmental and Molecular Mutagenesis · doi:10.1002/em.2850200104 · Cited by 33
Topoisomerase-II-mediated lesions in nascent DNA: Comparison of the effects of epipodophyllotoxin derivatives, VM-26 and VP-16, and 9-anilinoacridine derivatives, m-AMSA and o-AMSA
WOYNAROWSKI, J. M., Sigmund, R. D., & Beerman, T. A. (1988) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/0167-4781(88)90069-3 · Cited by 33
Insulin-like Growth Factor-1 Inhibits Cell Death Induced by Anticancer Drugs in the MCF-7 Cells: Involvement of Growth Factors in Drug Resistance
Geier, A., Beery, R., Haimsohn, M., & Karasik, A. (1995) · Cancer Investigation · doi:10.3109/07357909509024911 · Cited by 33
The ras Oncogene-Mediated Sensitization of Human Cells to Topoisomerase II Inhibitor-Induced Apoptosis
Koo, H.-M., Gray-Goodrich, M., Kohlhagen, G., McWilliams, M. J., Jeffers, M., Vaigro-Wolff, A., Alvord, W. G., Monks, A. P., Paull, K. D., Pommier, Y. G., et al. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.3.236 · Cited by 33
Cardiac safety profile of pegylated liposomal doxorubicin reaching or exceeding lifetime cumulative doses of 550 mg/m2 in patients with recurrent ovarian and peritoneal cancer
YILDIRIM, Y., Gültekin, E., Avcı, M. F., İnal, M. M., YUNUS, S., & Tınar, Ş. (2007) · International Journal of Gynecological Cancer · doi:10.1111/j.1525-1438.2007.00992.x · Cited by 32
A carboline derivative as a novel mammalian DNA topoisomerase II targeting agent
Pognan, F., Saucier, J.-M., Paoletti, C., Kaczmarek, Ł., Nantka-Namirski, P., Mordarski, M., & Peczynska-Czoch, W. (1992) · Biochemical Pharmacology · doi:10.1016/0006-2952(92)90341-f · Cited by 32
RETRACTED: Ellipticine-induced apoptosis depends on Akt translocation and signaling in lung epithelial cancer cells
Fang, K., Chen, S.-P., Lin, C.-W., Cheng, W.-C., & Huang, H.-T. (2008) · Lung Cancer · doi:10.1016/j.lungcan.2008.05.026 · Cited by 32
Retracted
Collision of Trapped Topoisomerase 2 with Transcription and Replication: Generation and Repair of DNA Double-Strand Breaks with 5′ Adducts
Yan, H., Tammaro, M., & Liao, S. (2016) · Genes · doi:10.3390/genes7070032 · Cited by 32
Topoisomerase II cleavage of herpes simplex virus type 1 DNA in vivo is replication dependent
Ebert, S. N., Shtrom, S., & Muller, M. T. (1990) · Journal of Virology · doi:10.1128/jvi.64.9.4059-4066.1990 · Cited by 32
New benzo[g]isoquinoline-5,10-diones and dihydrothieno [2,3-b]naphtho-4,9-dione derivatives
Gomez-Monterrey, I. M., Campiglia, P., Grieco, P., Diurno, M. V., Bolognese, A., Colla, P. L., & Novellino, E. (2003) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(03)00310-9 · Cited by 32
Inhibition of herpes simplex virus type 1 DNA polymerase by the natural product oosporein.
Terry, B., LIU, W.-C., Cianci, C., Proszynski, E., FERNANDES, P. B., Bush, K., & MEYERS, E. (1992) · The Journal of Antibiotics · doi:10.7164/antibiotics.45.286 · Cited by 32
Interaction of ellipticine and an indolo[2,3b]-quinoxaline derivative with DNA and synthetic polynucleotides
Zegar, I. S., Gräslund, A., Bergman, J., Eriksson, M., & Nordén, B. (1989) · Chemico-Biological Interactions · doi:10.1016/0009-2797(89)90004-5 · Cited by 32
Topoisomerase II-mediated DNA cleavage activity induced by ellipticines on the human tumor cell line N417
Multon, É. T., Riou, J., LeFevre, D., Ahomadegbe, J., & RIOU, G. F. (1989) · Biochemical Pharmacology · doi:10.1016/0006-2952(89)90060-9 · Cited by 32
Sequence-selective binding of an ellipticine derivative to DNA
Bailly, C., Ó’hUigín, C., Rivalle, C., Bisagni, É., Hénichart, J., & Waring, M. J. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.21.6283 · Cited by 32
Dipyridamole enhancement of etoposide sensitivity.
Howell, S. B., Hom, D. K., Sanga, R., Vick, J. S., & Chan, T. (1989) · PubMed · Cited by 32
Microwave induced three-component synthesis and antimycobacterial activity of benzopyrazolo[3,4-b]quinolindiones
Jairo Quiroga, P., Díaz, Y., Bueno, J., Braulio Insuasty, O., Abonı́a, R., Ortíz, A., Nogueras, M., & Cobo, J. (2014) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2013.12.037 · Cited by 31
Chemotherapeutic-Induced Cardiovascular Dysfunction: Physiological Effects, Early Detection—The Role of Telomerase to Counteract Mitochondrial Defects and Oxidative Stress
Quryshi, N., Toro, L. N., Ait‐Aissa, K., Kong, A. L., & Beyer, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030797 · Cited by 31
Multidrug-resistant hela cells overexpressing MRP1 exhibit sensitivity to cell killing by hyperthermia: Interactions with etoposide
Souslova, T., & Averill‐Bates, D. A. (2004) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2004.07.686 · Cited by 31
Centromere-associated topoisomerase activity in bloodstream form Trypanosoma brucei
Obado, S. O., Bot, C., Echeverry, M. C., Bayona, J. C., Álvarez, V. E., Taylor, M. C., & Kelly, J. M. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq839 · Cited by 31
Synthesis and biological evaluation of novel carbazole-rhodanine conjugates as topoisomerase II inhibitors
Jiang, H., Zhang, W., Li, P., Wang, J., Dong, C., Zhang, K., Chen, H., & Du, Z. (2018) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2018.03.017 · Cited by 31
Synthesis and topoisomerase inhibitory activities of novel aza-analogues of flavones11Part of the work was presented at the XIVth International Symposium on Medicinal Chemistry, Maastricht, NL, 1996 (Abst. P–10.17)
Sui, Z., Nguyen, V. N., Altom, J. D., Fernandez, J., Hilliard, J. J., Bernstein, J. I., Barrett, J. F., & Ohemeng, K. A. (1999) · European Journal of Medicinal Chemistry · doi:10.1016/s0223-5234(99)80087-7 · Cited by 31
Two specific topoisomerase II inhibitors prevent replication of human cytomegalovirus DNA: an implied role in replication of the viral genome
Benson, J. D., & Huang, E. S. (1988) · Journal of Virology · doi:10.1128/jvi.62.12.4797-4800.1988 · Cited by 31
BENZENE-INDUCED GENOTOXICITY
Whysner, J. A. (2000) · Journal of Toxicology and Environmental Health · doi:10.1080/00984100050166343 · Cited by 31
“Different classes have been demonstrated to induce different patterns of high-frequency site-specific cleavage by purified topoisomerase II (Tewey et al., 1984).”
Background
Mitochondrial Topoisomerase II Activity Is Essential for Kinetoplast DNA Minicircle Segregation
Shapiro, T. A. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.6.3660 · Cited by 31
Role of the semi-quinone free radical of the anti-tumour agent etoposide (VP-16-213) in the inactivation of single- and double-stranded ΦX174 DNA
Mans, D. R. A., Retèl, J., van Maanen, J., Lafleur, M. V. M., Schaik, M. A. V., Pinedo, H. M., & Lankelma, J. (1990) · British Journal of Cancer · doi:10.1038/bjc.1990.228 · Cited by 31
Bacteriophage T4 DNA topoisomerase is the target of antitumor agent 4'-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA) in T4-infected Escherichia coli.
Huff, A. C., Leatherwood, J. K., & Kreuzer, K. N. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.4.1307 · Cited by 31
Genetic characterization of the multidrug-resistant phenotype of VM-26-resistant human leukemic cells.
Wolverton, J. S., Danks, M. K., Schmidt, C., & Beck, W. T. (1989) · PubMed · Cited by 31
Adriamycin Induces Protein Oxidation in Erythrocyte Membranes
DeAtley, S. M., Aksenov, M. Y., Aksenova, M. V., Carney, J. M., & Butterfield, D. A. (1998) · Pharmacology & Toxicology · doi:10.1111/j.1600-0773.1998.tb01445.x · Cited by 30
Topoisomerase II in multiple drug resistance
Hofmann, G. A., & Mattern, M. R. (1993) · Cytotechnology · doi:10.1007/bf00744662 · Cited by 30
Association between the p170 form of human topoisomerase II and progeny viral DNA in cells infected with herpes simplex virus type 1
Ebert, S. N., Subramanian, D., Shtrom, S., Chung, I. K., Parris, D. S., & Muller, M. T. (1994) · Journal of Virology · doi:10.1128/jvi.68.2.1010-1020.1994 · Cited by 30
Etoposide (VP-16)
Hohenhaus, A. E., & Matus, R. E. (1990) · Journal of Veterinary Internal Medicine · doi:10.1111/j.1939-1676.1990.tb03115.x · Cited by 30
Topoisomerase II Site-directed Alkylation of DNA by Psorospermin and Its Effect on Topoisomerase II-mediated DNA Cleavage
Kwok, Y., & Hurley, L. H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.49.33020 · Cited by 30
A new compound, withangulatin A, promotes type II DNA topoisomerase-mediated DNA damage
Juang, J.-K., Huang, H. W., Chen, C., & Liu, H. J. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)92226-2 · Cited by 30
In Vivo Inhibition of Trypanosome Mitochondrial Topoisomerase II: Effects on Kinetoplast DNA Maxicircles
Shapiro, T. A., & Showalter, A. F. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.9.5891 · Cited by 30
Anthracycline-induced DNA breaks and resealing in doxorubicin-resistant murine leukemic P388 cells
Maniar, N., Krishan, A., Israel, M., & Samy, T. S. A. (1988) · Biochemical Pharmacology · doi:10.1016/0006-2952(88)90440-6 · Cited by 30
Re: The ras Oncogene-Mediated Sensitization of Human Cells to Topoisomerase II Inhibitor-Induced Apoptosis
Koo, H., & Woude, G. F. V. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.22.1969 · Cited by 30
Topoisomerase Assays
Nitiss, J. L., Kiianitsa, K., Sun, Y., Nitiss, K. C., & Maizels, N. (2021) · Current Protocols · doi:10.1002/cpz1.250 · Cited by 29
“The most Nitiss et al. 38 of 47 Current Protocols likely explanation for this pattern of responses is that high levels of intercalated compound completely block cleavage (Tewey et al., 1984).”
Background
Two High Throughput Screen Assays for Measurement of TNF-α in THP-1 Cells
Leister, K. P., Huang, R., Goodwin, B. L., Chen, A., Austin, C. P., & Xia, M. (2011) · Current Chemical Genomics · doi:10.2174/1875397301105010021 · Cited by 29
“Ellipticine, an alkaloid derived from the leaves of the evergreen tree, is known as a DNA intercalating agent [31] and an inhibitor of the enzyme topoisomerase II [32].”
Background
Covalent Attachment of Ethidium to DNA Results in Enhanced Topoisomerase II-Mediated DNA Cleavage
Marx, G., Zhou, H., Graves, D. E., & Osheroff, N. (1997) · Biochemistry · doi:10.1021/bi971858c · Cited by 29
Phase I and pharmacokinetic study of DACA (XR5000): a novel inhibitor of topoisomerase I and II
Twelves, C. J., Gardner, C., Flavin, A., Sludden, J., Dennis, I. F., Bono, J. S. D., Beale, P. J., Vasey, P. A., Hutchison, C., Macham, M. A., et al. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690598 · Cited by 29
Mutational alteration of the breakage/resealing subunit of bacteriophage T4 DNA topoisomerase confers resistance to antitumor agent m-AMSA
Huff, A. C., Ward, R. E., & Kreuzer, K. N. (1990) · Molecular and General Genetics MGG · doi:10.1007/bf00280363 · Cited by 29
“A presumptive reaction intermediate consists of topoisomerase covalently attached, via a phosphotyrosine bond, to each 5' terminus of the broken DNA (Rowe et al. 1984; Tse et al. 1980; Gellert et al. 1981 ; Tewey et al. 1984a).”
Background
Chapter 24. DNA Topoisomerases as Therapeutic Targets in Cancer Chemotherapy
Chen, G. L., & Liu, L. F. (1986) · Annual reports in medicinal chemistry · doi:10.1016/s0065-7743(08)61134-3 · Cited by 29
Self-citation
Combined inhibition of topoisomerases I and II - is this a worthwhile/feasible strategy?
Vasey, P. A., & Kaye, S. B. (1997) · British Journal of Cancer · doi:10.1038/bjc.1997.568 · Cited by 29
Effects of Olive Metabolites on DNA Cleavage Mediated by Human Type II Topoisomerases
Vann, K. R., Sedgeman, C. A., Gopas, J., Golan‐Goldhirsh, A., & Osheroff, N. (2015) · Biochemistry · doi:10.1021/acs.biochem.5b00162 · Cited by 28
Etoposide damages female germ cells in the developing ovary
Stefansdottir, A., Johnston, Z. C., Powles-Glover, N., Anderson, R. A., Adams, I. R., & Spears, N. (2016) · BMC Cancer · doi:10.1186/s12885-016-2505-9 · Cited by 28
In vivo Pharmacokinetic and Anticancer Studies of HH-N25, a Selective Inhibitor of Topoisomerase I, and Hormonal Signaling for Treating Breast Cancer
Lawal, B., Kuo, Y.-C., Sumitra, M. R., Wu, A. T. H., & Huang, H. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s329401 · Cited by 28
Unique biochemical, cytotoxic, and antitumor activity of camptothecin and 4β-amino-4′-O-demethylepipodophyllotoxin conjugates
Chang, J.-Y., Guo, X., Chen, H., Jiang, Z., Fu, Q., Wang, H., Bastow, K. F., Zhu, X.-K., Guan, J., Lee, K., et al. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00363-9 · Cited by 28
Topoisomerase II as a target of VM-26 and 4'-(9-acridinylamino)methanesulfon-m-aniside in atypical multidrug resistant human small cell lung carcinoma cells.
de Jong, S., Kooistra, A. J., de Vries, E. G. E., Mulder, N. H., & Zijlstra, J. G. (1993) · PubMed · Cited by 28
Clusters of S1 Nuclease-Hypersensitive Sites Induced In Vivo by DNA Damage
Legault, J., Tremblay, A., Ramotar, D., & Mirault, M.-É. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.9.5437 · Cited by 28
Drug sensitivity and cross-resistance of the 4'-(9-acridinylamino)methanesulfon-m-anisidide-resistant subline of HL-60 human leukemia.
Odaimi, M., Andersson, B. S., McCredie, K. B., & Beran, M. (1986) · PubMed · Cited by 28
Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity
Knight, J. R. P., Allison, S. J., & Milner, J. (2013) · Open Biology · doi:10.1098/rsob.130130 · Cited by 31
DNA Topoisomerase Inhibitors as Antifungal Agents
Shen, L. L., & Fostel, J. M. (1994) · Advances in pharmacology · doi:10.1016/s1054-3589(08)61140-0 · Cited by 27
Structure-Based Virtual Screening: An Application to Human Topoisomerase II α
Christmann‐Franck, S., Bertrand, H., Lamy, A., Garabedian, P. A. D., Mauffret, O., Hoffmann, R. D., & Fermandjian, S. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm049745w · Cited by 27
Interactions ofDrosophillaDNA topoisomerase II with left-handed Z-DNA in supercoiled minicircles
Glikin, G. C., Jovin, T. M., & Arndt-Jovin, D. J. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.25.7139 · Cited by 27
Biochemical Modulation of Cytotoxic Drugs by Cytokines: Molecular Mechanisms in Experimental Oncology
Kreuser, E. D., Wadler, S., & Thiel, E. (1995) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-642-78771-3_28 · Cited by 27
A Novel Topoisomerase II Poison GL331 Preferentially Induces DNA Cleavage at (C/G)T Sites and Can Cause Telomere DNA Damage
Lee, C.-C., & Huang, T. (2001) · Pharmaceutical Research · doi:10.1023/a:1011048831698 · Cited by 27
A phase I study of topotecan followed sequentially by doxorubicin in patients with advanced malignancies.
Tolcher, A. W., O’Shaughnessy, J., Weiss, R. B., Zujewski, J. A., Myhand, R., Schneider, E., Hakim, F., GRESS, R. E., Goldspiel, B. R., Noone, M., et al. (1997) · PubMed · Cited by 27
Arrest of Replication Fork Progression at Sites of Topoisomerase II-Mediated DNA Cleavage in Human Leukemia CEM Cells Incubated with VM-26
Catapano, C. V., Carbone, G. M., Pisani, F., Qiu, J., & Fernandes, D. (1997) · Biochemistry · doi:10.1021/bi963101b · Cited by 27
Multidrug resistance gene expression in rodents and rodent hepatocytes treated with mitoxantrone
Schrenk, D., Michalke, A., Gant, T. W., Brown, P. C., Silverman, J. A., & Thorgeirsson, S. S. (1996) · Biochemical Pharmacology · doi:10.1016/s0006-2952(96)00512-6 · Cited by 27
Pulsed-field gel electrophoresis analysis of higher-order chromatin structures of Zea mays. Highly methylated DNA in the 50 kb chromatin structure
Espinàs, M., & Carballo, M. (1993) · Plant Molecular Biology · doi:10.1007/bf00027116 · Cited by 16
A shuttle vector for analysis of illegitimate recombination in mammalian cells: effects of DNA topo-isomerase inhibitors on deletion frequency
Bae, Y., Masatoshi, C., Ohira, M., & Ikeda, H. (1991) · Gene · doi:10.1016/0378-1119(91)90425-b · Cited by 27
Modulation of 4'-(9-acridinylamino)methanesulfon-m-anisidide-induced, topoisomerase II-mediated DNA cleavage by gossypol.
Adlakha, R. C., Ashorn, C. L., Chan, D., & Zwelling, L. A. (1989) · PubMed · Cited by 27
Engagement with tNOX (ENOX2) to Inhibit SIRT1 and Activate p53-Dependent and -Independent Apoptotic Pathways by Novel 4,11-Diaminoanthra[2,3-b]furan-5,10-diones in Hepatocellular Carcinoma Cells
Lin, C.-Y., Islam, A., Su, C. J., Tikhomirov, A. S., Shchekotikhin, A. E., Chuang, S., Chueh, P. J., & Chen, Y. L. (2019) · Cancers · doi:10.3390/cancers11030420 · Cited by 26
“, are currently used as first-line treatments for HCC patients; the above-named moiety of these agents can interact with DNA duplexes to inhibit topoisomerase 2 (Topo2) and provoke apoptosis [4,5].”
Wortmannin potentiates the combined effect of etoposide and cisplatin in human glioma cells
Pastwa, E., Popławski, T., Lewandowska, U., Somiari, S., Błasiak, J., & Somiari, R. I. (2014) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.06.007 · Cited by 26
Topoisomerase 2 alpha: a real predictor of anthracycline efficacy?
Romero, A., Caldés, T., Díaz‐Rubio, E., & Martín, M. (2012) · Clinical & Translational Oncology · doi:10.1007/s12094-012-0779-1 · Cited by 26
Differences in Sensitivity to DNA-damaging Agents between XRCC4- and Artemis-deficient Human Cells
Katsube, T., Mori, M., Tsuji, H., Shiomi, T., Shiomi, N., & Onoda, M. (2011) · Journal of Radiation Research · doi:10.1269/jrr.10168 · Cited by 27
YM155 inhibits topoisomerase function
Hong, M., Ren, M., Silva, J., Paul, A., Wilson, W. D., Schroeder, C., Weinberger, P., Janik, J. E., & Hao, Z. (2016) · Anti-Cancer Drugs · doi:10.1097/cad.0000000000000441 · Cited by 26
Characterization, in vitro evaluation and comparative study on the cellular internalization of mesoporous silica nanoparticle-supported lipid bilayers
Yang, S., Song, S., Han, K., Wu, X., Chen, L., Hu, Y., Wang, J., & Liu, B. (2019) · Microporous and Mesoporous Materials · doi:10.1016/j.micromeso.2019.04.043 · Cited by 27
Topoisomerase II-mediated site-directed alkylation of DNA by psorospermin and its use in mapping other topoisomerase II poison binding sites
Kwok, Y., Zeng, Q., & Hurley, L. H. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.23.13531 · Cited by 26
Topostatin, a Novel Inhibitor of Topoisomerases I and II Produced by Thermomonospora alba Strain No. 1520. I. Taxonomy, Fermentation, Isolation and Biological Activities.
Suzuki, K., Nagao, K., Monnai, Y., Yagi, A., & Uyeda, M. (1998) · The Journal of Antibiotics · doi:10.7164/antibiotics.51.991 · Cited by 26
Topoisomerase I-targeting drugs
Gatto, B., & Liu, L. F. (1998) · Advances in DNA sequence-specific agents · doi:10.1016/s1067-568x(98)80005-4 · Cited by 26
Self-citation
Chemoprotection by 9-aminoacridine derivatives against the cytotoxicity of topoisomerase II-directed drugs
Finlay, G. J., Wilson, W. R., & Baguley, B. C. (1989) · European Journal of Cancer and Clinical Oncology · doi:10.1016/0277-5379(89)90337-4 · Cited by 26
Numerical and structural chromosome aberrations induced by etoposide (VP16) during oocyte maturation of mice: transmission to one-cell zygotes and damage to dictyate oocytes
Mailhes, J. B., Marchetti, F., Young, D., & London, S. N. (1996) · Mutagenesis · doi:10.1093/mutage/11.4.357 · Cited by 26
Transcription of adenovirus and HeLa cell genes in the presence of drugs that inhibit topoisomerase I and II function
Schaack, J. B., Schedl, P. D., & Shenk, T. E. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.6.1499 · Cited by 26

Authors: Tewey, K. M., Chen, G. L., Nelson, E. M., & Liu, L. F.
Affiliations: Johns Hopkins University (US)
ORCID: Liu, L F
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1984-07
Volume: 259
Issue: 14
Pages: 9182-9187
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1016/s0021-9258(17)47282-6
OpenAlex: W1514525963
Cited by: 887
References: 39
Citations by year: 2026: 2 · 2025: 6 · 2024: 4 · 2023: 4 · 2022: 6 · 2021: 9 · 2020: 10 · 2019: 16 · 2018: 9 · 2017: 15 · 2016: 19 · 2015: 14 · 2014: 14 · 2013: 16 · 2012: 14
FWCI: 15.02
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 13270 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer therapeutics and mechanisms
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Bioactive Compounds and Antitumor Agents
Health Sciences › Medicine › Oncology › Metal complexes synthesis and properties
Keywords: topoisomerase II, epipodophyllotoxins, etoposide, doxorubicin, cleavable complex, drug-enzyme interaction, nalidixic acid, DNA gyrase, cytotoxicity mechanism
MeSH terms: Alkaloids, Animals, Antineoplastic Agents, Cattle, DNA, DNA Topoisomerases, Type II, DNA Topoisomerases, Type I, DNA, Viral, Ellipticines, HeLa Cells, Humans, Intercalating Agents, Kinetics, Osmolar Concentration, Plasmids, Protein Binding, Thymus Gland

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks