The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Angiotensinogen-deficient mice with hypotension.
Open accessAbstract
The renin-angiotensin system is an enzymatic cascade that produces a potent vasoconstrictor octapeptide angiotensin II, through its physiologically inactive intermediate decapeptide angiotensin I, from their precursor angiotensinogen. In the present study, we generated angiotensinogen-deficient mice by homologous recombination in mouse embryonic stem cells. These mice do not produce angiotensinogen in the liver, resulting in the complete loss of plasma immunoreactive angiotensin I. The systolic blood pressure of the homozygous mutant mice was 66.9 +/- 4.1 mm Hg, significantly lower than that of wild-type mice (100.4 +/- 4.4 mm Hg). This profound hypotension in angiotensinogen-deficient mice demonstrates an indispensable role for the renin-angiotensin system in maintaining blood pressure.
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Cites
Thinking about genetic redundancy
Thomas, J. H. (1993) · Trends in Genetics · doi:10.1016/0168-9525(93)90140-d · Cited by 239
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Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II
Zou, Y., Akazawa, H., Qin, Y., Sano, M., Takano, H., Minamino, T., Makita, N., Iwanaga, K., Zhu, W., Kudoh, S., et al. (2004) · Nature Cell Biology · doi:10.1038/ncb1137 · Cited by 683
Self-citationPhysiology and Pathophysiology of the Adipose Tissue Renin-Angiotensin System
Engeli, S., Negrel, R., & Sharma, A. M. (2000) · Hypertension · doi:10.1161/01.hyp.35.6.1270 · Cited by 475
Angiotensin II Type 1a Receptor-deficient Mice with Hypotension and Hyperreninemia
Sugaya, T., Nishimatsu, S.-I., Tanimoto, K., Takimoto, E., Yamagishi, T., Imamura, K., Goto, S., Imaizumi, K., Hisada, Y., Otsuka, A., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.32.18719 · Cited by 366
Self-citationBernstein, K. E., Ong, F. S., Blackwell, W.-L. B., Shah, K. H., Giani, J. F., Gonzalez-Villalobos, R. A., Shen, X. Z., & Fuchs, S. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.006809 · Cited by 324
Metadata
- Authors
- Tanimoto, K., Sugiyama, F., Goto, Y., Ishida, J., Takimoto, E., Yagami, K., Fukamizu, A., & Murakami, K.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1994-12
- Volume
- 269
- Issue
- 50
- Pages
- 31334-31337
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2093548319
- Cited by
- 370
- References
- 1
- FWCI
- 15.28
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Tanimoto, K., Sugiyama, F., Goto, Y., Ishida, J., Takimoto, E., Yagami, K., Fukamizu, A., & Murakami, K. (1994). Angiotensinogen-deficient mice with hypotension. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)31697-1
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