The DOI matches its Crossref record.
Sperm from mice carrying a targeted mutation of the acrosin gene can penetrate the oocyte zona pellucida and effect fertilization.
Open accessAbstract
The physiological function of mammalian sperm acrosin has long been believed to be involved in the limited proteolysis of the oocyte zona pellucida, thus enabling the sperm to penetrate this extracellular matrix and to gain access to the oocyte plasma membrane. Here we show that male mice homozygous for a targeted mutation in the mouse acrosin gene are still fertile in spite of the complete absence of acrosin protease activity in the sperm. In vitro fertilization assays verified that sperm from the homozygous mutant mice penetrate the zona pellucida and effect fertilization. Therefore, acrosin is not essential for both sperm penetration of the zona pellucida and fertilization.
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Cited by
Glycobiology of sperm-egg interactions in deuterostomes
Mengerink, K. J., & Vacquier, V. D. (2001) · Glycobiology · doi:10.1093/glycob/11.4.37r · Cited by 103
Metadata
- Authors
- Baba, T., Azuma, S., Kashiwabara, S., & Toyoda, Y.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1994-12
- Volume
- 269
- Issue
- 50
- Pages
- 31845-31849
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1542710115
- Cited by
- 367
- References
- 0
- FWCI
- 13.27
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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