The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Biochemical and genetic analysis of variant mouse hepatoma cells defective in the induction of benzo(a)pyrene-metabolizing enzyme activity.
Open accessAbstract
We have analyzed wild type mouse hepatoma (Hepa 1c1c7) cells and variant cells which are defective in the induction of benzo(a)pyrene-metabolizing enzyme activity. One type of variant has no detectable basal or inducible aryl hydrocarbon hydroxylase activity. This class contains apparently normal cytosolic receptors for 2,3,7,8-tetrachlorodibenzo-p-dioxin, but is unable to translocate the inducer-receptor complex to the nucleus. The second type of variant has low levels of basal and inducible aryl hydrocarbon hydroxylase activity. This class contains cytosolic receptors which are decreased either in their number or in their ability to bind 2,3,7,8-tetrachlorodibenzo-p-dioxin; translocation of the inducer-receptor complex to the nucleus is apparently normal. Cell fusions indicate that both variant phenotypes are recessive with respect to wild type. Complementation analyses indicate that the defects are located on different genes.
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Poland, A., Glover, E., & Kende, A. S. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33205-2 · Cited by 1,370
Cited by
Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor.
Burbach, K. M., Poland, A., & Bradfield, C. A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.17.8185 · Cited by 831
Safe, S. H. (1986) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.26.040186.002103 · Cited by 710
Arsham, A. M., Howell, J. J., & Simon, M. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212770200 · Cited by 463
Denison, M. S., Fisher, J. M., & Whitlock, J. P. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)77819-3 · Cited by 451
Self-citationMa, Q., & Whitlock, J. P. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.14.8878 · Cited by 417
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Metadata
- Authors
- Miller, A. G., Israel, D., & Whitlock, J. P.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1983-03
- Volume
- 258
- Issue
- 6
- Pages
- 3523-3527
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1486593521
- Cited by
- 198
- References
- 1
- FWCI
- 10.58
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Miller, A. G., Israel, D., & Whitlock, J. P. (1983). Biochemical and genetic analysis of variant mouse hepatoma cells defective in the induction of benzo(a)pyrene-metabolizing enzyme activity. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)32693-0
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