The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Binding of synthetic oligosaccharides to the hepatic Gal/GalNAc lectin. Dependence on fine structural features.
Open accessAbstract
A series of synthetic oligosaccharides, resembling natural N-acetyllactosamine type glycans, were tested for their ability to inhibit the binding of labeled ligand to the mammalian hepatic lectin on rabbit hepatocytes at 2 degrees C. A dramatic hierarchy of inhibitory potency (tetraantennary greater than triantennary much greater than biantennary much greater than monoantennary) could be demonstrated. The range of concentration required for 50% inhibition of labeled ligand binding extended from approximately 1 mM, for the monoantennary oligosaccharides, to approximately 1 nM for triantennary oligosaccharides, even though the absolute Gal concentration increased only 3-fold. It was found that the number of Gal residues/cluster and their branching mode are major determinants of binding affinity of ligands to the hepatic lectin on the surface of hepatocytes.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“A single subcutaneous injection of trivalent GalNAc-conjugated siRNA can achieve efficacy for >12 months22, 2324.”
From A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system (2019) · cites this paper as [24]
Citations
Cites
THE PREPARATION OF 131I-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY
Greenwood, F. C., Hunter, W., & GLOVER, J. S. (1963) · Biochemical Journal · doi:10.1042/bj0890114 · Cited by 10,141
Enzyme changes in neonatal skeletal muscle: effect of thyroid deficiency
Baldwin, K. M., Hooker, A. M., Campbell, P., & Lewis, R. (1978) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1978.235.3.c97 · Cited by 1,118
Fournet, B., Montreuil, J., Strecker, G., DORLAND, L., Haverkamp, J., Vliegenthart, J. F. G., Binette, J. P., & Schmid, K. (1978) · Biochemistry · doi:10.1021/bi00617a021 · Cited by 419
Structural studies on the carbohydrate portion of fetuin.
Nilsson, B., Nordén, N. E., & Svensson, S. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)30046-7 · Cited by 353
2-Imino-2-methoxyethyl 1-thioglycosides: new reagents for attaching sugars to proteins
Lee, Y. C., Stowell, C. P., & Krantz, M. J. (1976) · Biochemistry · doi:10.1021/bi00663a008 · Cited by 335
Self-citationHuman hepatic lectin. Physiochemical properties and specificity.
Baenziger, J., & Maynard, Y. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85538-2 · Cited by 264
Structure of the complex oligosaccharides of fetuin.
Baenziger, J., & Fiete, D. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37874-2 · Cited by 250
Baenziger, J., & Fiete, D. (1980) · Cell · doi:10.1016/0092-8674(80)90371-2 · Cited by 248
Microheterogeneity of the carbohydrate group of Aspergillus oryzae α-amylase
McKelvy, J. F., & Lee, Y. C. (1969) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(69)90341-5 · Cited by 234
Self-citationConnolly, D. T., Townsend, R. R., Kawaguchi, K., Bell, W. R., & Lee, Y. C. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)68290-6 · Cited by 224
Self-citation
Cited by
Sorted by citations
The current landscape of nucleic acid therapeutics
Kulkarni, J. A., Witzigmann, D., Thomson, S. B., Chen, S., Leavitt, B. R., Cullis, P. R., & van der Meel, R. (2021) · Nature Nanotechnology · doi:10.1038/s41565-021-00898-0 · Cited by 1,371
Carbohydrate-Protein Interactions: Basis of Glycobiology
Lee, Y. C., & Lee, R. T. (1995) · Accounts of Chemical Research · doi:10.1021/ar00056a001 · Cited by 1,272
Self-citationNair, J. K., Willoughby, J. L. S., Chan, A., Charisse, K., Alam, M. R., Wang, Q., Hoekstra, M., Kandasamy, P., Kel’in, A. V., Milstein, S., et al. (2014) · Journal of the American Chemical Society · doi:10.1021/ja505986a · Cited by 1,141
Multivalent engagement of chromatin modifications by linked binding modules
Ruthenburg, A. J., Li, H., Patel, D. J., & Allis, C. D. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2298 · Cited by 1,039
Eto, T., & Takahashi, H. (1999) · Nature Medicine · doi:10.1038/8462 · Cited by 914
Metadata
- Authors
- Lee, Y. C., Townsend, R. R., Hardy, M. R., Lönngren, J., Arnarp, J., Haraldsson, M., & Lönn, H.
- Affiliations
- Johns Hopkins University (US)
- ORCID
- Haraldsson, M
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1983-01
- Volume
- 258
- Issue
- 1
- Pages
- 199-202
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1595570412
- Cited by
- 503
- References
- 24
- Citations by year
- 2026: 7 · 2025: 6 · 2024: 10 · 2023: 18 · 2022: 11 · 2021: 15 · 2020: 17 · 2019: 9 · 2018: 10 · 2017: 4 · 2016: 7 · 2015: 13 · 2014: 14 · 2013: 13 · 2012: 19
- FWCI
- 5.24
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Physical Sciences › Chemistry › Organic Chemistry › Carbohydrate Chemistry and Synthesis
- Life Sciences › Immunology and Microbiology › Immunology › Galectins and Cancer Biology
- Keywords
- Gal/GalNAc lectin, synthetic oligosaccharides, N-acetyllactosamine, oligosaccharide branching, hepatocytes
- MeSH terms
- Animals, Binding, Competitive, Carbohydrate Sequence, Cell Membrane, Glycopeptides, Kinetics, Liver, Oligosaccharides, Rabbits, Structure-Activity Relationship, Lectins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
