Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine).

Mechanism of inhibition of glutamine synthetase by methionine sulfoximine

Ronzio, R. A., Rowe, W. B., & Meister, A. (1969) · Biochemistry · doi:10.1021/bi00831a038 · Cited by 327

Inhibition of glutathione biosynthesis by prothionine sulfoximine (S-n-propyl homocysteine sulfoximine), a selective inhibitor of gamma-glutamylcysteine synthetase.

Griffith, O. W., Anderson, M. E., & Meister, A. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34188-1 · Cited by 172

Identification of L-methionine S-sulfoximine as the diastereoisomer of L-methionine SR-sulfoximine that inhibits glutamine synthetase

Manning, J. M., Moore, S., Rowe, W. B., & Meister, A. (1969) · Biochemistry · doi:10.1021/bi00834a066 · Cited by 166

Phosphorylation of methionine sulfoximine by glutamine synthetase.

Ronzio, R. A., & Meister, A. (1968) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.59.1.164 · Cited by 156

gamma-Glutamylcysteine synthetase. Further purification, "half of the sites" reactivity, subunits, and specificity.

Sekura, R. D., & Meister, A. (1977) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)40500-x · Cited by 149

Differential inhibition of glutamine and gamma-glutamylcysteine synthetases by alpha-alkyl analogs of methionine sulfoximine that induce convulsions.

Griffith, O. W., & Meister, A. (1978) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)38077-8 · Cited by 101

Computer analysis of the active site of glutamine synthetase

Gass, J. D., & Meister, A. (1970) · Biochemistry · doi:10.1021/bi00808a012 · Cited by 88

Action of nitrogen trichloride on certain proteins II. Synthesis of methionine sulphoximine and other sulphoximines

Bentley, H. R., McDermott, E. E., & Whitehead, J. K. (1951) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1951.0021 · Cited by 47

New synthesis of S-alkyl- DL -homocysteines

Kolenbrander, H. M. (1969) · Canadian Journal of Chemistry · doi:10.1139/v69-542 · Cited by 16

Studies on the Synthesis of Amino Acids by the Schmidt Reaction. VI. Synthesis of Methionine Sulfoximine Analogs

Hayahsi, K. (1960) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.8.177 · Cited by 6

Modulatory effect of glutathione status and antioxidants on methylmercury-induced free radical formation in primary cultures of cerebral astrocytes

Shanker, G., Syversen, T. L. M., Aschner, J. L., & Aschner, M. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2005.02.006 · Cited by 149

Redox regulation of pro-inflammatory cytokines and IκB-α/NF-κB nuclear translocation and activation

Haddad, J. J. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00947-6 · Cited by 148

Molecular regulation of cigarette smoke induced-oxidative stress in human retinal pigment epithelial cells: implications for age-related macular degeneration

BERTRAM, K. M., Baglole, C. J., Phipps, R. P., & Libby, R. T. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00126.2009 · Cited by 151

Cancer chemoresistance; biochemical and molecular aspects: a brief overview

Kachalaki, S., Ebrahimi, M., Khosroshahi, L. M., Mohammadinejad, S., & Baradaran, B. (2016) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2016.03.025 · Cited by 151

A compendium of kinetic modulatory profiles identifies ferroptosis regulators

Conlon, M., Poltorack, C. D., Forcina, G. C., Armenta, D. A., Mallais, M., Perez, M. A., Wells, A. C., Kahanu, A., Magtanong, L., Watts, J. L., et al. (2021) · Nature Chemical Biology · doi:10.1038/s41589-021-00751-4 · Cited by 152

Redox State Changes in Density-Dependent Regulation of Proliferation

Hutter, D., Till, B. G., & Greene, J. J. (1997) · Experimental Cell Research · doi:10.1006/excr.1997.3527 · Cited by 149

Selenoprotein P protects endothelial cells from oxidative damage by stimulation of glutathione peroxidase expression and activity

Steinbrenner, H., Steinbrenner, H., Bilgic, E., Steinbrenner, H., Bilgic, E., Alili, L., Sies, H., & Brenneisen, P. (2006) · Free Radical Research · doi:10.1080/10715760600806248 · Cited by 146

Role of glutathione in the maturation and fertilization of pig oocytes in vitro

YOSHIDA, M. (1993) · Molecular Reproduction and Development · doi:10.1002/mrd.1080350113 · Cited by 146

Effect of paclobutrazol on water stress amelioration through antioxidants and free radical scavenging enzymes in Arachis hypogaea L.

Sankar, B., Jaleel, C. A., Manivannan, P., Kishorekumar, A., Somasundaram, R., & Panneerselvam, R. (2007) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2007.06.016 · Cited by 145

Hydrogen peroxide inhibits gap junctional intercellular communication in glutathione sufficient but not glutathione deficient cells

Upham, B. L. (1997) · Carcinogenesis · doi:10.1093/carcin/18.1.37 · Cited by 145

Arabidopsis root growth dependence on glutathione is linked to auxin transport

Kopřivová, A., Mugford, S. T., & Kopřiva, S. (2010) · Plant Cell Reports · doi:10.1007/s00299-010-0902-0 · Cited by 144

ROS perception in Arabidopsis thaliana: the ozone‐induced calcium response

Evans, N. H., McAinsh, M. R., Hetherington, A. M., & Knight, M. R. (2005) · The Plant Journal · doi:10.1111/j.1365-313x.2004.02325.x · Cited by 143

Methylmercury-induced reactive oxygen species formation in neonatal cerebral astrocytic cultures is attenuated by antioxidants

Shanker, G., & Aschner, M. (2003) · Molecular Brain Research · doi:10.1016/s0169-328x(02)00642-3 · Cited by 143

Identification of a Pentatricopeptide Repeat Protein Implicated in Splicing of Intron 1 of Mitochondrial nad7 Transcripts

Kopřivová, A., Francs‐Small, C. C. D., Calder, G. M., Mugford, S. T., Tanz, S. K., Lee, B., Zechmann, B., Small, I., & Kopřiva, S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.147603 · Cited by 142

Effects of antioxidants on oxidant-induced sister chromatid exchange formation.

Weitberg, A. B., Weitzman, S. A., Clark, E. P., & Stossel, T. P. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111897 · Cited by 142

Heterogeneity of cellular glutathione among cells derived from a murine fibrosarcoma or a human renal cell carcinoma detected by flow cytometric analysis.

Shrieve, D. C., Bump, E. A., & Rice, G. C. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68191-8 · Cited by 142

Responses of growth and antioxidant systems in Carthamus tinctorius L. under water deficit stress

Hojati, M., Modarres‐Sanavy, S. A. M., Karimi, M., & Ghanati, F. (2010) · Acta Physiologiae Plantarum · doi:10.1007/s11738-010-0521-y · Cited by 139

Differential Multidrug Resistance-Associated Protein 1 through 6 Isoform Expression and Function in Human Intestinal Epithelial Caco-2 Cells

Prime-Chapman, H. M., Fearn, R. A., Cooper, A. E., Moore, V., & Hirst, B. H. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.068775 · Cited by 140

Inhibition of glutathione synthesis as a chemotherapeutic strategy for trypanosomiasis.

Arrick, B. A., Griffith, O. W., & Cerami, A. (1981) · The Journal of Experimental Medicine · doi:10.1084/jem.153.3.720 · Cited by 140

Lethal damage to endothelial cells by oxidized low density lipoprotein: role of selenoperoxidases in cytoprotection against lipid hydroperoxide- and iron-mediated reactions.

Thomas, J., Geiger, P., & Girotti, A. W. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)40739-4 · Cited by 140

Leydig cell aging and hypogonadism

Beattie, M. C., Adekola, L., Papadopoulos, V., Chen, H., & Zirkin, B. R. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.02.014 · Cited by 139

Effect of maturation media on male pronucleus formation in pig oocytes matured in vitro

YOSHIDA, M., Ishigaki, K., & Pursel, V. G. (1992) · Molecular Reproduction and Development · doi:10.1002/mrd.1080310112 · Cited by 137

Glutathione and metallothioneins as cellular defense against cadmium toxicity in cultured Chinese hamster cells

Ochi, T., Otsuka, F., Takahashi, K., & Ohsawa, M. (1988) · Chemico-Biological Interactions · doi:10.1016/0009-2797(88)90026-9 · Cited by 136

Glutathione antioxidant system and methylmercury-induced neurotoxicity: An intriguing interplay

Farina, M., & Aschner, M. (2019) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2019.01.007 · Cited by 137

Phosphine-induced oxidative damage in rats: role of glutathione

Hsu, C.-H., Chi, B.-C., Liu, M., Li, J., Chen, C., & Chen, R.-Y. (2002) · Toxicology · doi:10.1016/s0300-483x(02)00246-9 · Cited by 135

A mechanism for glutamate toxicity in the C6 glioma cells involving inhibition of cystine uptake leading to glutathione depletion

Kato, S., Negishi, K., Mawatari, K., & Kuo, C. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90278-a · Cited by 135

[27] Glutamine synthetase from mammalian tissues

Meister, A. (1985) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(85)13030-2 · Cited by 135

Regulation of antioxidants in cancer

Hecht, F., Zocchi, M., Alimohammadi, F., & Harris, I. S. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.11.001 · Cited by 138

Influence of glutathione (GSH) on net uptake of sulphate and sulphate transport in tobacco plants

Herschbach, C., & Rennenberg, H. (1994) · Journal of Experimental Botany · doi:10.1093/jxb/45.8.1069 · Cited by 132

Isolation of mutants of Schizosaccharomycespombe unable to synthesize cadystin, small cadmium-binding peptides

Mutoh, N., & Hayashi, Y. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(88)90555-4 · Cited by 132

Glutathione elevation during thermotolerance induction and thermosensitization by glutathione depletion.

Mitchell, J. B., Russo, A., Kinsella, T. J., & GLATSTEIN, E. J. (1983) · PubMed · Cited by 132

Sulfoximine: Eine vernachlässigte Chance in der medizinischen Chemie

Lücking, U. (2013) · Angewandte Chemie · doi:10.1002/ange.201302209 · Cited by 131

Synthesis, Characterization, and in Vitro Anticancer Activity of Copper and Zinc Bis(Thiosemicarbazone) Complexes

Anjum, R., Palanimuthu, D., Kalinowski, D. S., Lewis, W., Park, K. C., Kovačević, Ž., Khan, I. U., & Richardson, D. R. (2019) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.9b01281 · Cited by 132

Oxidation-triggered c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein (MAP) kinase pathways for apoptosis in human leukaemic cells stimulated by epigallocatechin-3-gallate (EGCG): a distinct pathway from those of chemically induced and receptor-mediated apoptosis

Saeki, K., Kobayashi, N., Inazawa, Y., Zhang, H., Nishitoh, H., Ichijo, H., Saeki, K., Isemura, M., & Yuo, A. (2002) · Biochemical Journal · doi:10.1042/bj20020101 · Cited by 129

The thioredoxin-1 system is essential for fueling DNA synthesis during T-cell metabolic reprogramming and proliferation

Muri, J., Heer, S., Matsushita, M., Pohlmeier, L. M., Tortola, L., Fuhrer, T., Conrad, M., Zamboni, N., Kisielow, J., & Köpf, M. (2018) · Nature Communications · doi:10.1038/s41467-018-04274-w · Cited by 134

Glucagon-like peptide-1 (GLP-1) protects against methylglyoxal-induced PC12 cell apoptosis through the PI3K/Akt/mTOR/GCLc/redox signaling pathway

Kimura, R., Okouchi, M., Fujioka, H., Ichiyanagi, A., Ryuge, F., Mizuno, T., Imaeda, K., Okayama, N., Kamiya, Y., Asai, K., et al. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.05.025 · Cited by 127

Animal models of fulminant hepatic failure: A critical evaluation

Newsome, P. N., Plevris, J. N., Nelson, L. J., & Hayes, P. C. (2000) · Liver Transplantation · doi:10.1002/lt.500060110 · Cited by 129

Glutathione Depletion Impairs Myogenic Differentiation of Murine Skeletal Muscle C2C12 Cells through Sustained NF-κB Activation

Ardite, E., Barberà, J. A., Roca, J., & Fernández-Checa, J. C. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63335-4 · Cited by 129

Multifaceted Roles of Glutathione and Glutathione-Based Systems in Carcinogenesis and Anticancer Drug Resistance

Hatem, E., Banna, N. E., & Huang, M. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7134 · Cited by 127

Dehydroascorbate reduction

Wells, W. W., & Xu, D. P. (1994) · Journal of Bioenergetics and Biomembranes · doi:10.1007/bf00762777 · Cited by 128

[74] Methods for the selective modification of glutathione metabolism and study of glutathione transport

Meister, A. (1985) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(85)13077-6 · Cited by 128

Elevated levels of polyamines and trypanothione resulting from overexpression of the ornithine decarboxylase gene in arsenite‐resistant Leishmania

Haimeur, A., Guimond, C., Pilote, S., Mukhopadhyay, R., Rosen, B. P., Poulin, R., & Ouellette, M. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01634.x · Cited by 127

Nitric oxide-donating aspirin induces apoptosis in human colon cancer cells through induction of oxidative stress

Gao, J., Liu, X., & Rigas, B. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506893102 · Cited by 127

Mechanism of action of paracetamol protective agents in mice in vivo

Miners, J. O., Drew, R., & Birkett, D. (1984) · Biochemical Pharmacology · doi:10.1016/0006-2952(84)90599-9 · Cited by 127

Potentiation of doxorubicin cytotoxicity by buthionine sulfoximine in multidrug-resistant human breast tumor cells.

Dusre, L., Mimnaugh, E. G., Myers, C. E., & Sinha, B. K. (1989) · PubMed · Cited by 127

Selenoprotein W during development and oxidative stress

Loflin, J., Lopez, N. I., Whanger, P. D., & Kioussi, C. (2006) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2006.05.018 · Cited by 126

Sequence‐selective DNA binding drugs mithramycin A and chromomycin A3 are potent inhibitors of neuronal apoptosis induced by oxidative stress and DNA damage in cortical neurons

Chatterjee, S., Zaman, K., Ryu, H., Conforto, A. B., & Ratan, R. R. (2001) · Annals of Neurology · doi:10.1002/ana.71.abs · Cited by 126

Antioxidative potentials as a protective mechanism in Catharanthus roseus (L.) G. Don. plants under salinity stress

Jaleel, C. A., Gopi, R., Manivannan, P., & Panneerselvam, R. (2007) · DergiPark (Istanbul University) · Cited by 125

Pantothenic acid and pantothenol increase biosynthesis of glutathione by boosting cell energetics

Slyshenkov, V. S., Dymkowska, D., & Wojtczak, L. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.05.044 · Cited by 125

On the active site thiol of gamma-glutamylcysteine synthetase: relationships to catalysis, inhibition, and regulation.

Huang, C. S., Moore, W. R., & Meister, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.8.2464 · Cited by 125

The identification of heme oxygenase as a major hypoxic stress protein in Chinese hamster ovary cells

Murphy, B. J., Laderoute, K. R., Short, S., & Sutherland, R. J. (1991) · British Journal of Cancer · doi:10.1038/bjc.1991.241 · Cited by 125

Glutathione Regulates Interleukin-2 Activity on Cytotoxic T-cells

Liang, C., Lee, N., Cattell, D., & Liang, S. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)80027-8 · Cited by 125

Evidence for redox regulation of cytochrome c release during programmed neuronal death: antioxidant effects of protein synthesis and caspase inhibition

Kirkland, R. A., & Franklin, J. L. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-06-01949.2001 · Cited by 126

Neuroprotective Action of Cycloheximide Involves Induction of Bcl-2 and Antioxidant Pathways

Furukawa, K., Estus, S., Fu, W., Mark, R. J., & Mattson, M. P. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.136.5.1137 · Cited by 122

The glutathione synthesis inhibitor buthionine sulfoximine synergistically enhanced melphalan activity against preclinical models of multiple myeloma

Tagde, A., Singh, H., Kang, M. H., & Reynolds, C. P. (2014) · Blood Cancer Journal · doi:10.1038/bcj.2014.45 · Cited by 123

Strategies for overcoming ABC-transporters-mediated multidrug resistance (MDR) of tumor cells.

Borowski, E., Bontemps‐Gracz, M. M., & Piwkowska, A. (2005) · Acta Biochimica Polonica · doi:10.18388/abp.2005_3421 · Cited by 123

Drug-induced lipid peroxidation in mice—II

Wendel, A., Jaeschke, H., & Gloger, M. (1982) · Biochemical Pharmacology · doi:10.1016/0006-2952(82)90582-2 · Cited by 123

Effects of H2O2 on protein tyrosine phosphatase activity in HER14 cells

Sullivan, S. G., Chiu, D. T.-Y., Errasfa, M., Wang, J. M., Qi, J.-S., & Stern, A. (1994) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(94)90042-6 · Cited by 122

Synthesis of seven different homologous phytochelatins in metal‐exposed Schizosaccharomyces pombe cells

Grill, E., Winnacker, E. ‐., & Zenk, M. H. (1986) · FEBS Letters · doi:10.1016/0014-5793(86)80309-x · Cited by 122

Zonation of acetaminophen metabolism and cytochrome P450 2E1-mediated toxicity studied in isolated periportal and perivenous hepatocytes

Anundi, I., Lähteenmäki, T., Rundgren, M., Moldeus, P., & Lindros, K. O. (1993) · Biochemical Pharmacology · doi:10.1016/0006-2952(93)90277-4 · Cited by 120

Hijacking membrane transporters for arsenic phytoextraction

LeBlanc, M. S., McKinney, E. C., Meagher, R. B., & Smith, A. P. (2012) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2012.10.013 · Cited by 120

Heavy metal transport by AtHMA4 involves the N‐terminal degenerated metal binding domain and the C‐terminal His11 stretch

Verret, F., Gravot, A., Auroy, P., Prévéral, S., Forestier, C., Vavasseur, A., & Richaud, P. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.01.065 · Cited by 124

Chemical transformation of toxic metals by a Pseudomonas strain from a toxic waste site

Blake, R. C., Choate, D. M., Bardhan, S., Revis, N. W., Barton, L. L., & Zocco, T. G. (1993) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620120806 · Cited by 120

Morita–Baylis–Hillman adducts: Biological activities and potentialities to the discovery of new cheaper drugs

Lima-Júnior, C. G., & Vasconcellos, M. L. A. A. (2012) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2012.04.061 · Cited by 119

ACTL6A protects gastric cancer cells against ferroptosis through induction of glutathione synthesis

Yang, Z., Zou, S., Zhang, Y., Zhang, J., Zhang, P., Xiao, L., Xie, Y., Meng, M., Feng, J., Kang, L., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39901-8 · Cited by 124

Cystine/glutamate antiporter expression in retinal mu¨ller glial cells: Implications fordl-alpha-aminoadipate toxicity

Kato, S., Ishita, S., Sugawara, K., & Mawatari, K. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90080-y · Cited by 119

Macrophage Glutathione Content and Glutathione Peroxidase Activity Are Inversely Related to Cell-Mediated Oxidation of LDL

Rosenblat, M., & Aviram, M. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(97)00231-1 · Cited by 121

On the Cycles of Glutathione Metabolism and Transport

Meister, A. (1981) · Current topics in cellular regulation · doi:10.1016/b978-0-12-152818-8.50009-8 · Cited by 119

Cysteine Depletion, a Key Action to Challenge Cancer Cells to Ferroptotic Cell Death

Daher, B., Vučetić, M., & Pouysségur, J. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00723 · Cited by 124

Protective roles of metallothionein and glutathione in hepatotoxicity of cadmium

Chan, H. M., & Cherian, M. G. (1992) · Toxicology · doi:10.1016/0300-483x(92)90179-i · Cited by 118

Triadimefon induced salt stress tolerance in Withania somnifera and its relationship to antioxidant defense system

Jaleel, C. A., Lakshmanan, G. M. A., Gomathinayagam, M., & Panneerselvam, R. (2007) · South African Journal of Botany · doi:10.1016/j.sajb.2007.10.003 · Cited by 118

All four Mycobacterium tuberculosis gln A genes encode glutamine synthetase activities but only GlnA1 is abundantly expressed and essential for bacterial homeostasis

Harth, G., Masleša-Galić, S., Tullius, M. V., & Horwitz, M. A. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04899.x · Cited by 118

Phytochelatins

Inouhe, M. (2005) · Brazilian Journal of Plant Physiology · doi:10.1590/s1677-04202005000100006 · Cited by 123

WILLIAM C. ROSE: LECTURESHIP IN BIOCHEMISTRY AND NUTRITION

Meister, A. (2009) · Nutrition Reviews · doi:10.1111/j.1753-4887.1984.tb02277.x · Cited by 118

Glutathione system in animal model of solid tumors: From regulation to therapeutic target

Corso, C. R., & Acco, A. (2018) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2018.05.014 · Cited by 120

Glutathione Is Present in Reproductive Tract Secretions and Improves Development of Mouse Embryos after Chemically Induced Glutathione Depletion1

Gardiner, C. S., Salmen, J. J., Brandt, C. J., & Stover, S. K. (1998) · Biology of Reproduction · doi:10.1095/biolreprod59.2.431 · Cited by 117

Free radical formation in cerebral cortical astrocytes in culture induced by methylmercury

Shanker, G., Aschner, J. L., Syversen, T. L. M., & Aschner, M. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.05.022 · Cited by 116

Inhibition of glutathione synthesis in the liver leads to S -adenosyl-L-methionine synthetase reduction

Corrales, F. J., Amo‐Ochoa, P., Rivas, C., Martín‐Lomas, M., Mato, J. M., & Pajares, M. A. (1991) · Hepatology · doi:10.1002/hep.1840140320 · Cited by 116

Quantitative imaging of glutathione in hippocampal neurons and glia in culture using monochlorobimane

Keelan, J., Allen, N. J., Antcliffe, D. B., Pal, S., & Duchen, M. R. (2001) · Journal of Neuroscience Research · doi:10.1002/jnr.10085 · Cited by 115

Metabolism of subtoxic levels of selenium in animals and humans.

Whanger, P. D., Vendeland, S. C., Park, Y.-C., & Xia, Y. (1996) · PubMed · Cited by 115

Cellular Glutathione Depletion by Diethyl Maleate or Buthionine Sulfoximine: No Effect of Glutathione Depletion on the Oxygen Enhancement Ratio

Mitchell, J. B., Russo, A., Biaglow, J. E., & McPherson, S. (1983) · Radiation Research · doi:10.2307/3576226 · Cited by 115

Glutathione-coated Cadmium-Sulfide Crystallites in Candida glabrata

Dameron, C. T., Smith, B. R., & Winge, D. R. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)71500-7 · Cited by 114

Essential Role of Glutathione in Acclimation to Environmental and Redox Perturbations in the Cyanobacterium Synechocystis sp. PCC 6803

Cameron, J. C., & Pakrasi, H. B. (2010) · PLANT PHYSIOLOGY · doi:10.1104/pp.110.162990 · Cited by 113

A NOVEL MODEL OF CONTINUOUS DEPLETION OF GLUTATHIONE IN MICE TREATED WITH L-BUTHIONINE(S,R)-SULFOXIMINE.

Watanabe, T., Sagisaka, H., Arakawa, S., Shibaya, Y., Watanabe, M., Igarashi, I., Tanaka, K., Totsuka, S., Takasaki, W., & Manabe, S. (2003) · The Journal of Toxicological Sciences · doi:10.2131/jts.28.455 · Cited by 113

Near-Total Glutathione Depletion and Age-Specific Cataracts Induced by Buthionine Sulfoximine in Mice

Calvin, H. I., Medvedovsky, C., & Worgul, B. V. (1986) · Science · doi:10.1126/science.3726547 · Cited by 113

Expression of antioxidant enzymes in human inflammatory cells

Pietarinen-Runtti, P., Lakari, E., Raivio, K. O., & Kinnula, V. L. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.278.1.c118 · Cited by 113

Antioxidants Inhibit Stimulation of HIV Transcription

Staal, F. J. T., Roederer, M., Raju, P. A., Anderson, M. T., Ela, S. W., Herzenberg, L. A., & Herzenberg, L. A. (1993) · AIDS Research and Human Retroviruses · doi:10.1089/aid.1993.9.299 · Cited by 114

Glutathione monoesters

Anderson, M. E., & Meister, A. (1989) · Analytical Biochemistry · doi:10.1016/0003-2697(89)90164-4 · Cited by 113

Role of glutathione in an animal model of myoglobinuric acute renal failure.

Abul‐Ezz, S. R., Walker, P. D., & Shah, S. V. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.21.9833 · Cited by 112

Acetaminophen,viaits reactive metaboliteN-acetyl-p-benzo-quinoneimine and transient receptor potential ankyrin-1 stimulation, causes neurogenic inflammation in the airways and other tissues in rodents

Nassini, R., Materazzi, S., Andrè, E., Sartiani, L., Aldini, G., Trevisani, M., Carnini, C., Massi, D., Pedretti, P., Carini, M., et al. (2010) · The FASEB Journal · doi:10.1096/fj.10-162438 · Cited by 112

Alterations in cytoskeletal protein sulfhydryls and cellular glutathione in cultured cells exposed to cadmium and nickel ions

Li, W., Zhao, Y., & Chou, I. (1993) · Toxicology · doi:10.1016/0300-483x(93)90138-i · Cited by 112

AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer

Kubli, S. P., Bassi, C., Roux, C., Wakeham, A. C., Göbl, C., Zhou, W., Jafari, S. M., Snow, B. E., Jones, L., Palomero, L., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1815126116 · Cited by 116

Proteomic Screens for Suppressors of Anoikis Identify IL1RAP as a Promising Surface Target in Ewing Sarcoma

Zhang, H., Hughes, C. S., Li, W., He, J., Surdez, D., El-Naggar, A. M., Cheng, H., Prudova, A., Delaidelli, A., Negri, G. L., et al. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1690 · Cited by 111

An important role for glutathione and γ-glutamyltranspeptidase in the supply of growth requirements during nitrogen starvation of the yeast Saccharomyces cerevisiae

Mehdi, K., & Penninckx, M. J. (1997) · Microbiology · doi:10.1099/00221287-143-6-1885 · Cited by 111

Regulation of hepatic glutathione metabolism and its role in hepatotoxicity

Kretzschmar, M. (1996) · Experimental and Toxicologic Pathology · doi:10.1016/s0940-2993(96)80054-6 · Cited by 111

Reduced Glutathione: A Radioprotector or a Modulator of DNA-Repair Activity?

Chatterjee, A. (2013) · Nutrients · doi:10.3390/nu5020525 · Cited by 118

Chromatographic and mass spectrometric analysis of glutathione in biological samples

Iwasaki, Y., Saito, Y., Nakano, Y., Mochizuki, K., Sakata, O., Ito, R., Saito, K., & Nakazawa, H. (2009) · Journal of Chromatography B · doi:10.1016/j.jchromb.2009.07.001 · Cited by 111

A Common Highly Conserved Cadmium Detoxification Mechanism from Bacteria to Humans

Prévéral, S., Gayet, L., Moldes, C., Hoffmann, J., Mounicou, S., Gruet, A., Reynaud, F., Łobiński, R., Verbavatz, J., Vavasseur, A., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m808130200 · Cited by 111

Glutathione as a depigmenting agent: an overview

Villarama, C. D., & Maïbach, H. I. (2005) · International Journal of Cosmetic Science · doi:10.1111/j.1467-2494.2005.00235.x · Cited by 111

The NAD+ precursors, nicotinic acid and nicotinamide protect cells against apoptosis induced by a multiple stress inducer, deoxycholate

Crowley, C., Payne, C. M., Bernstein, H., Bernstein, C., & Roe, D. J. (2000) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400658 · Cited by 113

Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis.

Griffith, O. W. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)33504-x · Cited by 701

Inhibition of glutathione biosynthesis by prothionine sulfoximine (S-n-propyl homocysteine sulfoximine), a selective inhibitor of gamma-glutamylcysteine synthetase.

Griffith, O. W., Anderson, M. E., & Meister, A. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)34188-1 · Cited by 172

Analytical and preparative separation of the diastereomers of l-buthionine (SR)-sulfoximine, a potent inhibitor of glutathione biosynthesis

Campbell, E. B., Hayward, M. L., & Griffith, O. W. (1991) · Analytical Biochemistry · doi:10.1016/0003-2697(91)90229-m · Cited by 47

Mechanism of inhibition of glutamine synthetase by methionine sulfoximine

Ronzio, R. A., Rowe, W. B., & Meister, A. (1969) · Biochemistry · doi:10.1021/bi00831a038 · Cited by 327

Inhibition of glutamine synthetase by methionine sulfoximine. Studies On Methionine sulfoximine phosphate

Rowe, W. B., Ronzio, R. A., & Meister, A. (1969) · Biochemistry · doi:10.1021/bi00834a065 · Cited by 163