The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The receptor for antidiabetic sulfonylureas controls the activity of the ATP-modulated K+ channel in insulin-secreting cells.
Open accessAbstract
Sulfonylureas are powerful hypoglycemic drugs that have been used for decades to treat diabetic patients. This paper describes a 86Rb+ flux technique that permits one to study easily the properties of ATP-modulated K+ channels in RINm5F insulinoma cells. Sulfonylureas inhibit this type of K+ channel under conditions of intracellular ATP depletion. The most potent sulfonylureas (glibenclamide, glipizide, and gliquidone) are acting in the nanomolar range of concentration. Inhibition of the single ATP-modulated K+ channels by low concentrations of sulfonylureas was also observed using the patch-clamp technique. The sulfonylurea receptor has been biochemically identified with [3H]glibenclamide. For 10 different sulfonylureas (or sulfonylurea analogs) there was an excellent correlation between efficacy of blockade of ATP-modulated K+ channels and efficacy of binding to the sulfonylurea receptors using the 3H-ligand.
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Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436
Glucose induces closure of single potassium channels in isolated rat pancreatic β-cells
Ashcroft, F. M., Harrison, D. E., & Ashcroft, S. J. H. (1984) · Nature · doi:10.1038/312446a0 · Cited by 1,113
Glucose dependent K+-channels in pancreatic?-cells are regulated by intracellular ATP
Rorsman, P., & Trube, G. (1985) · Pfl�gers Archiv European Journal of Physiology · doi:10.1007/bf00595682 · Cited by 387
Cited by
Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles
Hibino, H., Inanobe, A., Furutani, K., Murakami, S., Findlay, I., & Kurachi, Y. (2010) · Physiological Reviews · doi:10.1152/physrev.00021.2009 · Cited by 1,539
Molecular Biology of Adenosine Triphosphate-Sensitive Potassium Channels*
Aguilar-Bryan, L., & Bryan, J. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.2.0361 · Cited by 698
Sulphonylurea action revisited: the post-cloning era
Gribble, F. M., & Reimann, F. (2003) · Diabetologia · doi:10.1007/s00125-003-1143-3 · Cited by 284
Ashcroft, S. J. H., & Ashcroft, F. M. (1992) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/0167-4889(92)90008-y · Cited by 257
Rorsman, P., Bokvist, K., Ämmälä, C., Arkhammar, P., Berggren, P.-O., Larsson, O., & Wåhlander, K. (1991) · Nature · doi:10.1038/349077a0 · Cited by 135
Metadata
- Authors
- Schmid-Antomarchi, H., De Weille, J., Fosset, M., & Lazdunski, M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1987-11
- Volume
- 262
- Issue
- 33
- Pages
- 15840-15844
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1558512036
- Cited by
- 445
- References
- 3
- FWCI
- 10.04
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Schmid-Antomarchi, H., De Weille, J., Fosset, M., & Lazdunski, M. (1987). The receptor for antidiabetic sulfonylureas controls the activity of the ATP-modulated K+ channel in insulin-secreting cells. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)47664-8
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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