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Thyroxine transport in choroid plexus.
Open accessAbstract
The role of the choroid plexus in thyroid hormone transport between body and brain, suggested by strong synthesis and secretion of transthyretin in this tissue, was investigated in in vitro and in vivo systems. Rat choroid plexus pieces incubated in vitro were found to accumulate thyroid hormones from surrounding medium in a non-saturable process. At equilibrium, the ratio of thyroid hormone concentration in choroid plexus pieces to that in medium decreased upon increasing the concentration of transthyretin in the medium. Fluorescence quenching of fluorophores located at different depths in liposome membranes showed maximal hormone accumulation in the middle of the phospholipid bilayer. Partition coefficients of thyroxine and triiodothyronine between lipid and aqueous phase were about 20,000. After intravenous injection of 125I-labeled thyroid hormones, choroid plexus and parts of the brain steadily accumulated 125I-thyroxine, but not [125I]triiodothyronine, for many hours. The accumulation of 125I-thyroxine in choroid plexus preceded that in brain. The amount of 125I-thyroxine in non-brain tissues and the [125I]triiodothyronine content of all tissues decreased steadily beginning immediately after injection. A model is proposed for thyroxine transport from the bloodstream into cerebrospinal fluid based on partitioning of thyroxine between choroid plexus and surrounding fluids and binding of thyroxine to transthyretin newly synthesized and secreted by choroid plexus.
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Citations
Cited by
Hennemann, G., Docter, R., Friesema, E. C. H., de Jong, M., Krenning, E. P., & Visser, T. J. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.4.0435 · Cited by 394
Tu, H. M., Kim, S.-W., Salvatore, D., Bartha, T., Legradi, G., Larsen, P. R., & Lechan, R. M. (1997) · Endocrinology · doi:10.1210/endo.138.8.5318 · Cited by 302
Evolution of the Thyroid Hormone-Binding Protein, Transthyretin
Power, D. M., Elias, N. P., Richardson, S. J., Mendes, J., Soares, C. M., & Santos, C. R. A. (2000) · General and Comparative Endocrinology · doi:10.1006/gcen.2000.7520 · Cited by 226
Cell and molecular biology of transthyretin and thyroid hormones
Richardson, S. J. (2007) · International Review of Cytology · doi:10.1016/s0074-7696(07)58003-4 · Cited by 116
Kakucska, I., Rand, W., & Lechan, R. M. (1992) · Endocrinology · doi:10.1210/endo.130.5.1572297 · Cited by 113
Metadata
- Authors
- Dickson, P. W., Aldred, A. R., Menting, J. G., Marley, P. D., Sawyer, W. H., & Schreiber, G.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1987-10
- Volume
- 262
- Issue
- 29
- Pages
- 13907-13915
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1583700955
- Cited by
- 175
- References
- 0
- FWCI
- 7.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Dickson, P. W., Aldred, A. R., Menting, J. G., Marley, P. D., Sawyer, W. H., & Schreiber, G. (1987). Thyroxine transport in choroid plexus. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)47880-5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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