The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Orientation of non-blue cupric complexes on DNA fibers.
Open accessAbstract
Three different orientations of non-blue, type 2 cupric complexes on DNA fibers are obtained from EPR data. The cupric complex of bleomycin, CuBlm, binds as described previously (Shields, H., McGlumphy,C., and Hamrick, P., J., Jr. (1982) Biochim. Biophys. Acta 697, 113-120), except possibly with more restricted motion. The square plane of CuBlm makes an angle of about 65 degrees with the fiber axis. The tridentate complex 2-formylpyridine monothiosemicarbazonato Cu2+ binds with its planar structure perpendicular to the fiber axis. In contrast, other tridentate cupric complexes of tripeptides, CuGHK and CuGHG, bind with the square plane parallel to the fiber axis. The bound forms of Cu(GHK) and Cu(GHG) are determined mostly by the GH moiety in the complex; the contribution of lysine in defining the orientation of the copper moiety is minimal. Thus, the structure of the ligand determines the orientation of these complexes on DNA.
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In the citing paper
“Thus, it is possible that it can regulate gene activity directly [47].”
From Modulation of Gene Expression in Human Breast Cancer MCF7 and Prostate Cancer PC3 Cells by the Human Copper-Binding Peptide GHK-Cu (2021) · cites this paper as [47]
In the citing paper
“It is worth noticing that GHK-Cu can bind to the DNA molecule, forming copper-complexes.”
From Modulation of Gene Expression in Human Breast Cancer MCF7 and Prostate Cancer PC3 Cells by the Human Copper-Binding Peptide GHK-Cu (2021) · cites this paper as [47]
Citations
Cites
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Copper(II) facilitates bleomycin-mediated unwinding of plasmid DNA
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Properties of the binding of copper by bleomycin
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Self-citationReaction of FeB1m with DNA: Fe(II)B1m-NO
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Self-citationMetallobleomycins: electron spin resonance study on nitrosyl complex of iron(II)-Bleomycin
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Self-citationThe conformation and orientation of copper(II)-bleomycin intercalated with DNA
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The orientation of the ligands in iron(III)-bleomycin intercalated with DNA
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Research works printed but not linked: 2
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- Froncisz, 1982, J. Magn. Res., 47, 515
Cited by
Pickart, L., & Margolina, A. (2021) · OBM Genetics · doi:10.21926/obm.genet.2102128 · Cited by 3
Metadata
- Authors
- Chikira, M., Sato, T., Antholine, W. E., & Petering, D. H.
- Affiliations
- Chuo University (JP)
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1991-02
- Volume
- 266
- Issue
- 5
- Pages
- 2859-2863
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1593416864
- Cited by
- 30
- References
- 21
- Citations by year
- 2021: 1 · 2018: 1 · 2014: 1
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- creativecommons.org/licenses/by/4.0/ (vor, 10844 d)
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (7r01ca022184-17)
- National Cancer Institute (CA-22184)
- National Center for Research Resources (P41RR001008, RR 01008)
- Topics
- Health Sciences › Medicine › Oncology › Metal complexes synthesis and properties
- Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Keywords
- DNA binding, bleomycin, DNA fibers, tridentate ligands, ligand structure, copper coordination geometry
- MeSH terms
- Bleomycin, DNA, Electron Spin Resonance Spectroscopy, Temperature, Molecular Structure
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
