Arrangement of a highly repeated DNA sequence in the genome and chromatin of the African green monkey
Open accessAbstract
The DNA of the African green monkey contains three components that are distinguishable by the kinetics of reassociation. The rapidly reassociating component represents about 20% of the total DNA and is composed almost entirely of a sequence (AGMr(HindIII)-1) which is repeated 6.8 x 10(6) times. The majority of the AGMr(HindIII)-1 sequences are organized in long tandem repeats of a segment of 172 base pairs in length. However, a fraction of the AGMr (HindIII)-1 sequences is interspersed with another 37% of the genome. The structure of the chromatin containing the AGMr-(HindIII)-1 sequence is indistinguishable from that containing total DNA. Furthermore, there is nothing inherent in the nucleotide sequence of AGMr(HindIII)-1 which specifies a unique location for nucleosomes.
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The AGMr(HindIII)-1 sequence mainly appears in the form of long tandem repeats and is interspersed with unrelated sequences; the former has a maximum observed number of 29 long tandem repeats, and the latter accounts for approximately 37% of the total genome.
“This sequence mainly appears in the form of long tandem repeats and is interspersed with unrelated sequences. The former has a maximum observed number of 29 long tandem repeats; the latter accounts for approximately 37% of the total genome [37].”
From Evaluation of the Efficacy of the Vaccine Production Process in Removing Residual Host Cell DNA from the Vero Cell Rabies Vaccine (2024) · cites this paper as [37]
There is a highly repetitive satellite sequence, AGMr(HindIII)-1, in Vero cells, with a monomer length of 172 bp, accounting for approximately 15% of the total genome.
“There is a highly repetitive satellite sequence, AGMr(HindIII)-1, in Vero cells, with a monomer length of 172 bp, accounting for approximately 15% of the total genome.”
From Evaluation of the Efficacy of the Vaccine Production Process in Removing Residual Host Cell DNA from the Vero Cell Rabies Vaccine (2024) · cites this paper as [37]
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Weintraub, H., & Groudine, M. (1976) · Science · doi:10.1126/science.948749 · Cited by 1,809 · see citing works
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Development of a Vero cell DNA reference standard for residual DNA measurement in China
Cao, S., Dong, G., Tang, J., Li, J., Liu, J., Shi, L., Li, C., & Wang, J. (2013) · Human Vaccines & Immunotherapeutics · doi:10.4161/hv.22699 · Cited by 12 · see citing works
“This pattern of cleavage was consistent with previous report.(5) Finally, the origin of DNA was validated by DNA sequencing.”
ResultLi, J., Pan, R., Yue, F., Gao, T., Wu, X., Shi, L., Wang, Y., Zhao, D., Lan, Z., Chen, H., et al. (2024) · Vaccines · doi:10.3390/vaccines12121379 · Cited by 8 · see citing works
- Authors
- Singer, D. S.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Singer, D S
- ORCID
- Singer, D S
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1979-06
- Volume
- 254
- Issue
- 12
- Pages
- 5506-5514
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W126482590
- Cited by
- 57
- References
- 1
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2021: 1 · 2013: 1
- FWCI
- 18.71
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomic variations and chromosomal abnormalities
- Keywords
- vervet monkey, tandem repeats, DNA reassociation kinetics, chromatin structure, nucleosome positioning, genome organization, interspersed repeats
- MeSH terms
- Animals, Haplorhini, Base Sequence, Cell Line, Chlorocebus aethiops, Chromatin, DNA, Genes, Kinetics, Nucleic Acid Hybridization, Nucleic Acid Renaturation
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