The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Interleukin-1 beta-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans. Role of nitric oxide in interleukin-1 beta-induced inhibition of insulin secretion.
Open accessAbstract
The molecular mechanism by which interleukin (IL)-1 inhibits insulin secretion and ultimately causes destruction of the pancreatic beta-cell remains unknown. Evidence is presented which suggests that IL-1 beta-induced inhibition of insulin secretion is dependent on the metabolism of L-arginine to nitric oxide. NG-Monomethylarginine, a competitive inhibitor of the L-arginine-dependent enzyme nitric oxide synthase, completely prevents IL-1-induced inhibition of glucose-stimulated insulin secretion as well as nitrite production by islets. It is further shown that IL-1 beta induces nitric oxide formation in islets as evidenced by an electron paramagnetic resonance feature at g = 2.04 which is similar to previously reported iron-nitrosyl complexes formed from the destruction of iron-sulfur centers by nitric oxide. Inhibition of the nitric oxide synthase by NG-monomethylarginine completely prevents the formation of this EPR signal in islets. These results show that IL-1-induced inhibition of insulin secretion is mediated through formation of nitric oxide and suggest that the generation of nitric oxide may represent the cellular mechanism responsible for beta-cell destruction.
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Cites
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Cited by
Selective inhibition of the inducible nitric oxide synthase by aminoguanidine
Misko, T. P., Moore, W. M., Kasten, T. P., Nickols, G. A., Corbett, J. A., Tilton, R. G., McDaniel, M. L., Williamson, J. R., & Currie, M. G. (1993) · European Journal of Pharmacology · doi:10.1016/0014-2999(93)90357-n · Cited by 721
Self-citationRabinovitch, A., & Suarez-Pinzon, W. L. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)00492-9 · Cited by 466
Autoimmune Destruction of Pancreatic β Cells
Yoon, J.-W., & Jun, H.-S. (2005) · American Journal of Therapeutics · doi:10.1097/01.mjt.0000178767.67857.63 · Cited by 308
Nitric oxide in inflammation and immune response
Moilanen, E., & Vapaatalo, H. (1995) · Annals of Medicine · doi:10.3109/07853899509002589 · Cited by 242
Maciejewski, J. P., Selleri, C., Sato, T., Cho, H. J., Keefer, L. K., Nathan, C. F., & Young, N. S. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118094 · Cited by 209
Metadata
- Authors
- Corbett, J. A., Lancaster, J. R., Sweetland, M. A., & McDaniel, M. L.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1991-11
- Volume
- 266
- Issue
- 32
- Pages
- 21351-21354
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1517806507
- Cited by
- 259
- References
- 29
- FWCI
- 22.52
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Interleukin-1 beta-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans. Role of nitric oxide in interleukin-1 beta-induced inhibition of insulin secretion. https://app.cochat.ai/papers/10.1016/s0021-9258(18)54642-1
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- Corbett, J. A., Lancaster, J. R., Sweetland, M. A., & McDaniel, M. L. (1991). Interleukin-1 beta-induced formation of EPR-detectable iron-nitrosyl complexes in islets of Langerhans. Role of nitric oxide in interleukin-1 beta-induced inhibition of insulin secretion. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)54642-1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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