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Protection from tumor necrosis factor-mediated cytolysis by overexpression of plasminogen activator inhibitor type-2.
Open accessAbstract
Pretreatment of HT-1080 fibrosarcoma cells with tumor necrosis factor (TNF) induced resistance to the cytolytic activity of this cytokine in combination with cycloheximide. This resistance correlated with the synthesis of plasminogen activator inhibitor type-2 (PAI-2). HT-1080 cells were transfected with a PAI-2 expression vector in both sense and antisense orientation. The resistance to TNF-mediated cytolysis of transfected cell clones was correlated with the level of PAI-2 expression. Cells expressing antisense PAI-2 RNA showed reduced expression of PAI-2 and increased sensitivity to TNF-mediated cytolysis. Cells expressing constitutively PAI-2 were treated with TNF and cycloheximide to select cells with increased resistance to cytolysis and enhanced PAI-2 expression. PAI-2 gradually disappeared during a treatment with TNF and cycloheximide. This finding suggested that PAI-2 formed a complex with a target proteinase, which could be involved in mediating the cytolytic activity of TNF.
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Cites
An endotoxin-induced serum factor that causes necrosis of tumors
Carswell, E. A., Old, L. J., Kassel, R. L., Green, S., Fiore, N., & Williamson, B. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.9.3666 · Cited by 4,532
Cited by
Involvement of an ICE-like protease in Fas-mediated apoptosis
Enari, M., Hug, H., & Nagata, S. (1995) · Nature · doi:10.1038/375078a0 · Cited by 734
Apoptosis: Molecular Regulation of Cell Death
Hale, A. J., Smith, C. A., Sutherland, L. C., Stoneman, V. E. A., Longthorne, V. L., Culhane, A. C., & Williams, G. T. (1996) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1996.00001.x · Cited by 656
Stehlik, C., de Martin, R., Kumabashiri, I., Schmid, J. A., Binder, B. R., & Lipp, J. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.1.211 · Cited by 635
Role of matrix metalloproteinases (MMPs) in colorectal cancer
Zucker, S., & Vacirca, J. (2004) · Cancer and Metastasis Reviews · doi:10.1023/a:1025867130437 · Cited by 506
Krikos, A., Laherty, C. D., & Dixit, V. M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)37138-8 · Cited by 444
Metadata
- Authors
- Kumar, S., & Baglioni, C.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1991-11
- Volume
- 266
- Issue
- 31
- Pages
- 20960-20964
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1533816737
- Cited by
- 186
- References
- 1
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kumar, S., & Baglioni, C. (1991). Protection from tumor necrosis factor-mediated cytolysis by overexpression of plasminogen activator inhibitor type-2. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)54804-3
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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