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THE ESTIMATION OF ANTIPYRINE IN BIOLOGICAL MATERIALS
Open accessAbstract
A means of measuring the total water of the body in vivo has been developed (1). This method involves the use of antipyrine (l-phenyl-2,3dimethylpyrazolone-5-one), the well known analgesic and antipyretic. Two methods for the determination of this compound in biological materials are described in this report. The first, an extraction procedure, is suitable for its estimation in biological fluids and tissues. In this procedure antipyrine is extracted from the biological material with chloroform, the solvent evaporated, and the residue dissolved in dilute sulfuric acid. Sodium nitrite is added and the resulting 4-nitrosoantipyrine measured in a spectrophotometer at 350 mp. This procedure, as indicated by a distribution technique (2, 3), possesses a high degree of specificity. The second method, suitable for plasma, involves the estimation of the antipyrine directly in the plasma filtrate after deproteinization with zinc hydroxide. The speed and simplicity of this method recommend it for routine use. This procedure also has a high degree of specificity.
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Citations
Cited by
The Gross Composition of the Body
SIRI, W. E. (1956) · Advances in Biological and Medical Physics · doi:10.1016/b978-1-4832-3110-5.50011-x · Cited by 1,765
ASCORBIC ACID IN AROMATIC HYDROXYLATION
Udenfriend, S., Clark, C. T., Axelrod, J., & Brodie, B. B. (1954) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)65598-x · Cited by 677
Self-citationTreatment of pruritus of primary biliary cirrhosis with rifampin
Podesta, A., Lopez, P., Terg, R., Villamil, F., Flores, D., Mastai, R., Udaondo, C. B., & Companc, J. P. (1991) · Digestive Diseases and Sciences · doi:10.1007/bf01300759 · Cited by 267
Treatment of pruritus in primary biliary cirrhosis with rifampin
Ghent, C. N., & Carruthers, S. G. (1988) · Gastroenterology · doi:10.1016/0016-5085(88)90442-8 · Cited by 257
The effect of antipyrine, phenobarbitol and rifampicin on thyroid hormone metabolism in man
OHNHAUS, E. E., BÜRGI, H., BURGER, A., & STUDER, H. (1981) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1981.tb02000.x · Cited by 50
Metadata
- Authors
- Brodie, B. B., Axelrod, J., Soberman, R., & Levy, B. B.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1949-05
- Volume
- 179
- Issue
- 1
- Pages
- 25-29
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W137943138
- Cited by
- 409
- References
- 0
- FWCI
- 5.94
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Brodie, B. B., Axelrod, J., Soberman, R., & Levy, B. B. (1949). THE ESTIMATION OF ANTIPYRINE IN BIOLOGICAL MATERIALS. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)56807-1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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