The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Regulation of 5-aminolevulinate synthase mRNA in different rat tissues.
Open accessAbstract
cDNA clones for rat liver 5-aminolevulinate synthase have been isolated and used to examine mRNA levels in different rat tissues. Northern hybridization analysis of total RNA from various rat tissues showed the presence of a single 5-aminolevulinate synthase mRNA species of estimated length 2.3 kilobases. Primer extension and RNase mapping studies indicated that the mRNA is identical in all tissues. Highest basal levels were seen in liver and heart. Administration of hemin to rats reduced the basal level of this mRNA only in liver but the heme precursor, 5-aminolevulinate (or its methyl ester), repressed the basal levels in liver, kidney, heart, testis, and brain. The drug 2-allyl-2-isopropylacetamide increased the mRNA level in liver and kidney only while human chorionic gonadotropin hormone elevated the level in testis. Administration of the heme precursor 5-aminolevulinate prevented these inductions. Nuclear transcriptional run-off experiments in liver cell nuclei showed that 2-allyl-2-isopropylacetamide and 5-aminolevulinate exert their effect by altering the rate of transcription of the 5-aminolevulinate synthase gene. The results indicate that a single 5-aminolevulinate synthase mRNA is expressed in all tissues and that its transcription is negatively regulated by heme.
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“Moreover, there is evidence that heme not only regulates ALAS1 mitochondrial import but also attenuates its transcription [36,37].”
From Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer (2011) · cites this paper as [36]
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Metadata
- Authors
- Srivastava, G., Borthwick, I. A., Maguire, D. J., Elferink, C. J., Bawden, M. J., Mercer, J. F., & May, B. K.
- Affiliations
- The University of Adelaide (AU)
- ORCID
- Elferink, C J
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1988-04
- Volume
- 263
- Issue
- 11
- Pages
- 5202-5209
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1506718658
- Cited by
- 107
- References
- 26
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2016: 1 · 2013: 1 · 2012: 2
- FWCI
- 4.64
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heme Oxygenase-1 and Carbon Monoxide
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal Health and Biochemistry
- Keywords
- 5-aminolevulinate synthase, mRNA expression, tissue-specific gene expression, heme regulation, 5-aminolevulinic acid, human chorionic gonadotropin, transcriptional regulation, heme biosynthesis, liver, kidney, testis, cDNA cloning
- MeSH terms
- 5-Aminolevulinate Synthetase, Animals, Base Sequence, Codon, DNA, Hemin, Male, Molecular Sequence Data, Nucleic Acid Hybridization, Rats, Inbred Strains, Ribonucleases, RNA, Messenger, Tissue Distribution, Transcription, Genetic, Rats
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