CoChat
Sign Up
Cited by 78

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Two asialoglycoprotein receptor polypeptides in human hepatoma cells

Bischoff, J, Lodish, H F·1987·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(18)60888-9
Open this paper in CoChat — free account

Abstract

Two cDNA clones isolated from a HepG2 lambda gt11 library encode the classical asialoglycoprotein receptor, H1, as well as a homologous membrane glycoprotein, H2 (Spiess, M., and Lodish, H.F. (1985) Proc. Natl. Acad. Sci. U.S.A. 82, 6465-6469). To study the relationship of H2 to H1 and its possible role in receptor-mediated endocytosis of desialyated glycoproteins, we generated anti-peptide antibodies that are specific for each polypeptide. As judged by metabolic labeling of HepG2 cells and specific immunoadsorption, the biosynthesis of H2 is similar to H1 (Schwartz, A.L., and Rup, D. (1983) J. Biol. Chem. 258, 11249-11255); H2 is synthesized as a 43,000-dalton precursor polypeptide containing high mannose-type oligosaccharides, that is processed to a 50,000-dalton mature glycoprotein containing complex-type oligosaccharides. Both H1 and H2 have a half-life of approximately 12 h. Trypsin and neuraminidase digestion of intact cells at 4 and 12 degrees C was used to determine that, at steady state, 50-60 percent of both H1 and H2 are on the cell surface. Furthermore, all of the H2 molecules were digested by extracellular neuraminidase in 1 h at 37 degrees C, indicating that all gain access to the plasma membrane. Both H1 and H2 were purified to homogeneity when Triton X-100-solubilized membrane proteins from [35S]cysteine-labeled cells were subjected to affinity chromatography on galactose-agarose. Since we cannot detect a complex between mature H1 and H2, H2 must be a galactos…

Overview

Integrity signals

Registry

Crossref · 10.1016/s0021-9258(18)60888-9

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • In humans, the functional ASGR is composed of two subunits, ASGR1 (major, approximately 46 kDa) and ASGR2 (minor, approximately 50 kDa), that exist as homo-oligomers or hetero-oligomers in a molar ratio of approximately 3:1.

    “In humans, the functional receptor is composed of two subunits, ASGR1 (major, ∼46 kDa) and ASGR2 (minor, ∼50 kDa), that exist as homo-oligomers or hetero-oligomers in a molar ratio of ∼3:1, respectively (13, 31).”

    From Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLR cleaved by furin (2021) · cites this paper as [13]

  • Hepatic ASGR is pivotal for the efficient clearance of desialylated glycoproteins from circulation by receptor-mediated endocytosis and lysosomal degradation, whereupon ASGR is recycled back to the cell surface.

    “The hepatic ASGR is pivotal for the efficient clearance of desialylated glycoproteins from circulation by receptor-mediated endocytosis and lysosomal degradation, whereupon ASGR is recycled back to the cell surface (13, 31).”

    From Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLR cleaved by furin (2021) · cites this paper as [13]

  • Both ASGR subunits are type II, single-pass transmembrane proteins.

    “Both subunits are type II, single-pass transmembrane proteins.”

    From Asialoglycoprotein receptor 1 is a novel PCSK9-independent ligand of liver LDLR cleaved by furin (2021) · cites this paper as [13]

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 37

  1. Baenziger, 1980, J. Biol. Chem., 255, 4607, 10.1016/S0021-9258(19)85538-2 · DOI
  2. Breitfeld, 1985, Int. Rev. Cytol., 97, 47, 10.1016/S0074-7696(08)62348-7 · DOI
  3. Spiess, 1985, J. Biol. Chem., 260, 1979, 10.1016/S0021-9258(18)89497-2 · DOI
  4. Spiess, 1985, Proc. Natl. Acad. Sci. U. S. A., 82, 6465, 10.1073/pnas.82.19.6465 · DOI
  5. Hudgin, 1974, J. Biol. Chem., 249, 5536, 10.1016/S0021-9258(20)79761-9 · DOI
  6. Hsueh, 1986, J. Biol. Chem., 261, 4940, 10.1016/S0021-9258(19)89196-2 · DOI
  7. Tanabe, 1979, J. Biol. Chem., 254, 1038, 10.1016/S0021-9258(17)34164-9 · DOI
  8. Schwartz, 1981, Proc. Natl. Acad. Sci. U. S. A., 78, 3348, 10.1073/pnas.78.6.3348 · DOI
  9. Drickamer, 1984, J. Biol. Chem., 259, 770, 10.1016/S0021-9258(17)43524-1 · DOI
  10. McPhaul, 1986, Proc. Natl. Acad. Sci. U. S. A., 83, 8863, 10.1073/pnas.83.23.8863 · DOI
  11. Kawasaki, 1976, J. Biol. Chem., 251, 1296, 10.1016/S0021-9258(17)33740-7 · DOI
  12. Barany, 1979, Vol. 2, 1
  13. Green, 1982, Cell, 28, 477, 10.1016/0092-8674(82)90202-1 · DOI
  14. Walter, 1983, Methods Enzymol., 96, 84, 10.1016/S0076-6879(83)96010-X · DOI
  15. Knowles, 1980, Science, 209, 497, 10.1126/science.6248960 · DOI
  16. Laemmli, 1970, Nature, 227, 680, 10.1038/227680a0 · DOI · Paper page
  17. Skinner, 1983, Biochem. J., 209, 281, 10.1042/bj2090281 · DOI
  18. Breitfeld, 1984, J. Biol. Chem., 259, 10414, 10.1016/S0021-9258(18)90980-4 · DOI
  19. Schwartz, 1983, J. Biol. Chem., 258, 11249, 10.1016/S0021-9258(17)44410-3 · DOI
  20. Tarentino, 1985, Biochemistry, 24, 4665, 10.1021/bi00338a028 · DOI
  21. Farquhar, 1985, Annu. Rev. Cell Biol., 1, 447, 10.1146/annurev.cb.01.110185.002311 · DOI
  22. Kaplan, 1979, J. Biol. Chem., 254, 7329, 10.1016/S0021-9258(18)50323-9 · DOI
  23. Dunn, 1980, J. Biol. Chem., 255, 5971, 10.1016/S0021-9258(19)70726-1 · DOI
  24. Griffiths, 1986, Science, 234, 438, 10.1126/science.2945253 · DOI
  25. Matlin, 1983, Cell, 34, 233, 10.1016/0092-8674(83)90154-X · DOI
  26. Saraste, 1984, Cell, 38, 535, 10.1016/0092-8674(84)90508-7 · DOI
  27. Cresswell, 1985, Proc. Natl. Acad. Sci. U. S. A., 82, 8188, 10.1073/pnas.82.23.8188 · DOI
  28. Schwartz, 1982, J. Biol. Chem., 257, 4230, 10.1016/S0021-9258(18)34710-0 · DOI
  29. Geuze, 1983, Cell, 32, 277, 10.1016/0092-8674(83)90518-4 · DOI
  30. Geuze, 1984, EMBO J., 3, 2677, 10.1002/j.1460-2075.1984.tb02193.x · DOI
  31. Huber, 1986, J. Biol. Chem., 261, 12400, 10.1016/S0021-9258(18)67254-0 · DOI
  32. Kreiss, 1986, Cell, 46, 929, 10.1016/0092-8674(86)90075-9 · DOI
  33. Gething, 1986, Cell, 46, 939, 10.1016/0092-8674(86)90076-0 · DOI
  34. Copeland, 1986, J. Cell Biol., 103, 1179, 10.1083/jcb.103.4.1179 · DOI
  35. Anderson, 1982, J. Biol. Chem., 257, 8036, 10.1016/S0021-9258(18)34293-5 · DOI
  36. Schwartz, 1984, J. Biol. Chem., 259, 12025, 10.1016/S0021-9258(20)71314-1 · DOI
  37. Loeb, 1987, J. Biol. Chem., 262, 3022, 10.1016/S0021-9258(18)61463-2 · DOI

Cited by

Sorted by citations

Metadata

Authors
Bischoff, J., & Lodish, H. F.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1987-08
Volume
262
Issue
24
Pages
11825-11832
ISSN
0021-9258
DOI
10.1016/s0021-9258(18)60888-9
Cited by
78
References
1
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review