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Cited by 963

The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.

Metallothionein: a Cadmium- and Zinc-containing Protein from Equine Renal Cortex

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Kägi, Jeremias H.R., Vallee, Bert L.·1960·Journal of Biological Chemistry
DOI 10.1016/s0021-9258(18)64490-4
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Abstract

The initial purification of metallothionein from equine renal cortex yielded preparations that were electrophoretically heterogeneous and contained 2.9% cadmium, 0.6% zinc, and 4.1% sulfur (1). By diethylaminoethyl cellulose column chromatography, we have now obtained electrophoretically and ultracentrifugally homogeneous metallothionein containing 5.9 ‘% cadmium, 2.2% zinc, and 8.5% sulfur. Most of the sulfur in metallothionein is accounted for by its cysteine content. The molecular weight of the protein is 10,000 =t 260. The specific absorption of metallothionein at 250 rnp is shown to be a convenient monitor for its isolation. This absorption is characteristic of cadmium mercaptides, as indicated by the study of metallothionein and of cadmium complexes of monoand dimercaptans. These spectral properties have been utilized in the examination of cadmium and zinc binding to thionein, the metal-free protein. A preliminary report has been given (2).

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Metadata

Authors
Kägi, J. H. R., & Vallee, B. L.
Venue
Journal of Biological Chemistry
Publisher
Elsevier BV
Published
1960-12
Volume
235
Issue
12
Pages
3460-3465
ISSN
0021-9258 (ISSN-L)
DOI
10.1016/s0021-9258(18)64490-4
OpenAlex
W123589679
Cited by
963
References
11
FWCI
4.11
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Metallothionein: a Cadmium- and Zinc-containing Protein from Equine Renal Cortex. https://app.cochat.ai/papers/10.1016/s0021-9258(18)64490-4
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Kägi, J. H. R., & Vallee, B. L. (1960). Metallothionein: a Cadmium- and Zinc-containing Protein from Equine Renal Cortex. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)64490-4

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.